Abstract:
:During complex tasks, patterns of functional connectivity differ from those in the resting state. However, what accounts for such differences remains unclear. Brain activity during a task reflects an unknown mixture of spontaneous and task-evoked activities. The difference in functional connectivity between a task state and the resting state may reflect not only task-evoked functional connectivity, but also changes in spontaneously emerging networks. Here, we characterized the differences in apparent functional connectivity between the resting state and when human subjects were watching a naturalistic movie. Such differences were marginally explained by the task-evoked functional connectivity involved in processing the movie content. Instead, they were mostly attributable to changes in spontaneous networks driven by ongoing activity during the task. The execution of the task reduced the correlations in ongoing activity among different cortical networks, especially between the visual and non-visual sensory or motor cortices. Our results suggest that task-evoked activity is not independent from spontaneous activity, and that engaging in a task may suppress spontaneous activity and its inter-regional correlation.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Lynch LK,Lu KH,Wen H,Zhang Y,Saykin AJ,Liu Zdoi
10.1002/hbm.24335subject
Has Abstractpub_date
2018-12-01 00:00:00pages
4939-4948issue
12eissn
1065-9471issn
1097-0193journal_volume
39pub_type
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