Task-evoked functional connectivity does not explain functional connectivity differences between rest and task conditions.

Abstract:

:During complex tasks, patterns of functional connectivity differ from those in the resting state. However, what accounts for such differences remains unclear. Brain activity during a task reflects an unknown mixture of spontaneous and task-evoked activities. The difference in functional connectivity between a task state and the resting state may reflect not only task-evoked functional connectivity, but also changes in spontaneously emerging networks. Here, we characterized the differences in apparent functional connectivity between the resting state and when human subjects were watching a naturalistic movie. Such differences were marginally explained by the task-evoked functional connectivity involved in processing the movie content. Instead, they were mostly attributable to changes in spontaneous networks driven by ongoing activity during the task. The execution of the task reduced the correlations in ongoing activity among different cortical networks, especially between the visual and non-visual sensory or motor cortices. Our results suggest that task-evoked activity is not independent from spontaneous activity, and that engaging in a task may suppress spontaneous activity and its inter-regional correlation.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Lynch LK,Lu KH,Wen H,Zhang Y,Saykin AJ,Liu Z

doi

10.1002/hbm.24335

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

4939-4948

issue

12

eissn

1065-9471

issn

1097-0193

journal_volume

39

pub_type

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