Attentional modulation of emotional stimulus processing: an fMRI study using emotional expectancy.

Abstract:

:We used emotional expectancy to study attentional modulation in the processing of emotional stimuli. During functional magnetic resonance imaging (fMRI), volunteers saw emotional and neutral expectancy cues signaling the subsequent presentation of corresponding emotional or neutral pictorial stimuli. As a control, emotional and neutral pictures were presented without preceding expectancy cue, resulting in a 2 x 2 factorial design with the factors "expectancy" and "emotion." Statistical analysis revealed a significant positive interaction effect between these factors in the medial prefrontal cortex (MPFC, Brodmann area [BA] 9/10), amygdala, and dorsal midbrain. In all these regions, expectancy augmented the neural response to emotional but not to neutral pictures. Time course analysis of raw data suggests that this augmented activation was not preceded by baseline increases in MPFC and amygdala during the period of emotional expectancy. In a post-scanning session, the paradigm was presented for a second time to allow emotional intensity rating. Again, a significant interaction between expectancy and emotion was observed, with intensity ratings specifically enhanced in emotional photographs preceded by expectancy. There was a positive correlation between intensity ratings and blood oxygenation level-dependent (BOLD) signals in the left amygdala. We conclude that specific components of the emotion network show enhanced activation in response to emotional stimuli when these are preceded by expectancy. This enhancement effect is not present in neutral pictures and might parallel accentuated subjective feeling states.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Bermpohl F,Pascual-Leone A,Amedi A,Merabet LB,Fregni F,Gaab N,Alsop D,Schlaug G,Northoff G

doi

10.1002/hbm.20209

keywords:

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

662-77

issue

8

eissn

1065-9471

issn

1097-0193

journal_volume

27

pub_type

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