Mapping structural differences of the corpus callosum in individuals with 18q deletions using targetless regional spatial normalization.

Abstract:

:Individuals with a constitutional chromosome abnormality consisting of a deletion of a portion of the long arm of chromosome 18 (18q-) have a high incidence ( approximately 95%) of dysmyelination. Neuroradiologic findings in affected children report a smaller corpus callosum, but this finding has not been quantified. This is in part due to the large intersubject variability of the corpus callosum size and shape and the small number of subjects with 18q-, which leads to low statistical power for comparison with typically developing children. An analysis method called targetless spatial normalization (TSN) was used to improve the sensitivity of statistical testing. TSN converges all images in a group into what is referred as group common space. The group common space conserves common shape, size, and orientation while reducing intragroup variability. TSN in conjunction with a Witelson vertical partitioning scheme was used to assess differences in corpus callosum size between 12 children with 18q- and 12 age-matched normal controls. Significant global and regional differences in corpus callosum size were seen. The 18q- group showed an overall smaller (25%) corpus callosum (P < 10(-7)), even after correction for differences in brain size. Regionally, the posterior portions of corpus callosum (posterior midbody, isthmus, and splenium), which contain heavily myelinated fibers, were found to be 25% smaller in the population with 18q-.

journal_name

Hum Brain Mapp

journal_title

Human brain mapping

authors

Kochunov P,Lancaster J,Hardies J,Thompson PM,Woods RP,Cody JD,Hale DE,Laird A,Fox PT

doi

10.1002/hbm.20090

keywords:

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

325-31

issue

4

eissn

1065-9471

issn

1097-0193

journal_volume

24

pub_type

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