Abstract:
:Cognitive dysfunction is common in patients with multiple sclerosis (MS). Saccadic eye movement paradigms such as antisaccades (AS) can sensitively interrogate cognitive function, in particular, the executive and attentional processes of response selection and inhibition. Although we have previously demonstrated significant deficits in the generation of AS in MS patients, the neuropathological changes underlying these deficits were not elucidated. In this study, 24 patients with relapsing-remitting MS underwent testing using an AS paradigm. Rank correlation and multiple regression analyses were subsequently used to determine whether AS errors in these patients were associated with: (i) neurological and radiological abnormalities, as measured by standard clinical techniques, (ii) cognitive dysfunction, and (iii) regionally specific cerebral white and gray-matter damage. Although AS error rates in MS patients did not correlate with clinical disability (using the Expanded Disability Status Score), T2 lesion load or brain parenchymal fraction, AS error rate did correlate with performance on the Paced Auditory Serial Addition Task and the Symbol Digit Modalities Test, neuropsychological tests commonly used in MS. Further, voxel-wise regression analyses revealed associations between AS errors and reduced fractional anisotropy throughout most of the cerebellum, and increased mean diffusivity in the cerebellar vermis. Region-wise regression analyses confirmed that AS errors also correlated with gray-matter atrophy in the cerebellum right VI subregion. These results support the use of the AS paradigm as a marker for cognitive dysfunction in MS and implicate structural and microstructural changes to the cerebellum as a contributing mechanism for AS deficits in these patients.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Kolbe SC,Kilpatrick TJ,Mitchell PJ,White O,Egan GF,Fielding Jdoi
10.1002/hbm.22329subject
Has Abstractpub_date
2014-05-01 00:00:00pages
2310-9issue
5eissn
1065-9471issn
1097-0193journal_volume
35pub_type
杂志文章abstract::We compared two experimental designs aimed at minimizing the influence of scanner background noise (SBN) on functional MRI (fMRI) of auditory processes with one conventional fMRI design. Ten subjects listened to a series of four one-syllable words and had to decide whether two of the words were identical. This was con...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20298
更新日期:2007-08-01 00:00:00
abstract::Adolescence is a time period associated with marked brain maturation that coincides with an enhanced risk for onset of psychiatric disorder. White matter tract myelination, a process that continues to unfold throughout adolescence, is reported to be abnormal in several psychiatric disorders. Here, we ask whether psych...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24842
更新日期:2020-02-15 00:00:00
abstract::People tend to lie in varying degrees. To advance our understanding of the underlying neural mechanisms of this heterogeneity, we investigated individual differences in self-serving lying. We performed a functional magnetic resonance imaging study in 37 participants and introduced a color-reporting game where lying ab...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24432
更新日期:2019-03-01 00:00:00
abstract::A theoretical framework supporting experimental measures of dynamic properties of human EEG is proposed with emphasis on distinct alpha rhythms. Robust relationships between measured dynamics and cognitive or behavioral conditions are reviewed, and proposed physiological bases for EEG at cellular levels are considered...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
doi:10.1002/hbm.1030
更新日期:2001-07-01 00:00:00
abstract::Sedation has a graded effect on brain responses to auditory stimuli: perceptual processing persists at sedation levels that attenuate more complex processing. We used fMRI in healthy volunteers sedated with propofol to assess changes in neural responses to spoken stimuli. Volunteers were scanned awake, sedated, and du...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22375
更新日期:2014-07-01 00:00:00
abstract::Auditory steady-state responses (ASSRs) are evoked brain responses to modulated or repetitive acoustic stimuli. Investigating the underlying neural generators of ASSRs is important to gain in-depth insight into the mechanisms of auditory temporal processing. The aim of this study is to reconstruct an extensive range o...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25262
更新日期:2021-02-15 00:00:00
abstract::Cognitive procedural learning occurs in three qualitatively different phases (cognitive, associative, and autonomous). At the beginning of this process, numerous cognitive functions are involved, subtended by distinct brain structures such as the prefrontal and parietal cortex and the cerebellum. As the learning progr...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20605
更新日期:2009-04-01 00:00:00
abstract::The sudden onset of a face image leads to a prominent face-selective response in human scalp electroencephalographic (EEG) recordings, peaking 170 ms after stimulus onset at occipito-temporal (OT) scalp sites: the N170 (or M170 in magnetoencephalography). According to a widely held view, the main cortical source of th...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24455
更新日期:2019-04-01 00:00:00
abstract::Navigated transcranial magnetic stimulation (TMS) can be used to stimulate functional cortical areas at precise anatomical location to induce measurable responses. The stimulation has commonly been focused on anatomically predefined motor areas: TMS of that area elicits a measurable muscle response, the motor evoked p...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20942
更新日期:2010-08-01 00:00:00
abstract::Although the brain areas in the default-mode network (DMN) act in a coordinated way during rest, the activity levels in the individual areas of the DMN are highly heterogeneous. The relation between the activity levels and the pattern of causal interaction among the DMN areas remains unknown. In the present fMRI study...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21065
更新日期:2011-01-01 00:00:00
abstract::Inattentional deafness is the failure to hear otherwise audible sounds (usually alarms) that may occur under high workload conditions. One potential cause for its occurrence could be an attentional bottleneck that occurs when task demands are high, resulting in lack of resources for processing of additional tasks. In ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23735
更新日期:2017-11-01 00:00:00
abstract::This study examined global resting-state functional connectivity of neural oscillations in individuals with chronic tinnitus and normal and impaired hearing. We tested the hypothesis that distinct neural oscillatory networks are engaged in tinnitus with and without hearing loss. In both tinnitus groups, with and witho...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24981
更新日期:2020-07-01 00:00:00
abstract::We present a novel, computerized method of examining cerebral cortical thickness. The normal cortex varies in thickness from 2 to 4 mm, reflecting the morphology of neuronal sublayers. Cortical pathologies often manifest abnormal variations in thickness, with examples of Alzheimer's disease and cortical dysplasia as t...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/1097-0193(200009)11:1<12::aid-hbm20>3.0.co
更新日期:2000-09-01 00:00:00
abstract::In this study we demonstrate that the pattern of an amygdala-centric network contributes to individual differences in trait anxiety. Individual differences in trait anxiety were predicted using maximum likelihood estimates of amygdala structural connectivity to multiple brain targets derived from diffusion-tensor imag...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22952
更新日期:2015-12-01 00:00:00
abstract::The reproducibility of activation patterns in the whole brain obtained by functional magnetic resonance imaging (fMRI) experiments at 4 Tesla was studied with a simple finger-opposition task. Six subjects performed three runs in one session, and each run was analyzed separately with the t-test as a univariate method a...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(sici)1097-0193(1999)7:4<267::aid-hbm5>3.0
更新日期:1999-01-01 00:00:00
abstract::The preprocessing pipelines typically used in both task and resting-state functional magnetic resonance imaging (rs-fMRI) analysis are modular in nature: They are composed of a number of separate filtering/regression steps, including removal of head motion covariates and band-pass filtering, performed sequentially and...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24528
更新日期:2019-06-01 00:00:00
abstract::Studying the early dynamic development of cortical folding with remarkable individual variability is critical for understanding normal early brain development and related neurodevelopmental disorders. This study focuses on the fingerprinting capability and the individual variability of cortical folding during early br...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24924
更新日期:2020-06-01 00:00:00
abstract::This study investigated the cortical responses underlying magnitude comparisons of multisensory stimuli and examined the effect that musical expertise has in this process. The comparative judgments were based on a newly learned rule binding the auditory and visual stimuli within the context of magnitude comparisons: "...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22558
更新日期:2014-11-01 00:00:00
abstract::Verbal stimuli often induce right-hemispheric activation in patients with aphasia after left-hemispheric stroke. This right-hemispheric activation is commonly attributed to functional reorganization within the language system. Yet previous evidence suggests that functional activation in right-hemispheric homologues of...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21512
更新日期:2013-06-01 00:00:00
abstract::Classically, model-based segmentation procedures match magnetic resonance imaging (MRI) volumes to an expertly labeled atlas using nonlinear registration. The accuracy of these techniques are limited due to atlas biases, misregistration, and resampling error. Multi-atlas-based approaches are used as a remedy and invol...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22092
更新日期:2013-10-01 00:00:00
abstract::Fast cancellation or switching of action plans is a critical cognitive function. Rapid signal transmission is key for quickly executing and inhibiting responses, and the structural integrity of connections between brain regions plays a crucial role in signal transmission speed. In this study, we used the search-step t...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23209
更新日期:2016-08-01 00:00:00
abstract::Compared with complex coordinated orofacial actions, few neuroimaging studies have attempted to determine the shared and distinct neural substrates of supralaryngeal and laryngeal articulatory movements when performed independently. To determine cortical and subcortical regions associated with supralaryngeal motor con...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21363
更新日期:2012-10-01 00:00:00
abstract::Word production is a complex multistage process linking conceptual representations, lexical entries, phonological forms and articulation. Previous studies have revealed a network of predominantly left-lateralized brain regions supporting this process, but many details regarding the precise functions of different nodes...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20782
更新日期:2009-11-01 00:00:00
abstract::We studied the relationship between muscle activity (electromyography, EMG), force, and brain activity during isometric contractions of the index finger, on a group and individual level. Ten subjects contracted their right or left index finger at 5, 15, 30, 50, and 70% of their maximal force. Subjects received visual ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20388
更新日期:2008-03-01 00:00:00
abstract::Major depressive disorder (MDD) is highly prevalent and associated with considerable morbidity, yet its pathophysiology remains only partially understood. While numerous studies have investigated the neurobiological correlates of MDD, most have used only a single neuroimaging modality. In particular, diffusion tensor ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24679
更新日期:2019-09-01 00:00:00
abstract::Fluent readers process written text rapidly and accurately, and comprehend what they read. Historically, reading fluency has been modeled as the product of discrete skills such as single word decoding. More recent conceptualizations emphasize that fluent reading is the product of competency in, and the coordination of...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21384
更新日期:2012-11-01 00:00:00
abstract::In previous work (Penny et al., [2005]: Neuroimage 24:350-362) we have developed a spatially regularised General Linear Model for the analysis of functional magnetic resonance imaging data that allows for the characterisation of regionally specific effects using Posterior Probability Maps (PPMs). In this paper we show...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20327
更新日期:2007-04-01 00:00:00
abstract::Theoretical models of addiction suggest that a substance use disorder represents an imbalance between hypersensitive motivational processes and deficient regulatory executive functions. Working-memory (a central executive function) may be a powerful predictor of the course of drug use and drug-related problems. Goal o...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22342
更新日期:2014-05-01 00:00:00
abstract::Functional organization units of the cerebral cortex exist over a wide range of spatial scales, from local circuits to entire cortical areas. In the last decades, scale-space representations of neuroimaging data suited to probe the multi-scale nature of cortical functional organization have been introduced and methodo...
journal_title:Human brain mapping
pub_type: 杂志文章,随机对照试验
doi:10.1002/hbm.21274
更新日期:2012-05-01 00:00:00
abstract::The cingulum bundle is a white matter fiber bundle in the human brain that is believed to be implicated in various neurological and psychiatric diseases. Subtle disease-related differences in metabolite concentrations in the cingulum tracts that may underlie these diseases may be detected using MR spectroscopic inform...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21302
更新日期:2012-07-01 00:00:00