Abstract:
:Normal aging is accompanied by an interindividually variable decline in cognitive abilities and brain structure. This variability, in combination with methodical differences and differences in sample characteristics across studies, pose a major challenge for generalizability of results from different studies. Therefore, the current study aimed at cross-validating age-related differences in cognitive abilities and brain structure (measured using cortical thickness [CT]) in two large independent samples, each consisting of 228 healthy older adults aged between 65 and 85 years: the Longitudinal Healthy Aging Brain (LHAB) database (University of Zurich, Switzerland) and the 1000BRAINS (Research Centre Jülich, Germany). Participants from LHAB showed significantly higher education, physical well-being, and cognitive abilities (processing speed, concept shifting, reasoning, semantic verbal fluency, and vocabulary). In contrast, CT values were larger for participants of 1000BRAINS. Though, both samples showed highly similar age-related differences in both, cognitive abilities and CT. These effects were in accordance with functional aging theories, for example, posterior to anterior shift in aging as was shown for the default mode network. Thus, the current two-study approach provides evidence that independently on heterogeneous metrics of brain structure or cognition across studies, age-related effects on cognitive ability and brain structure can be generalized over different samples, assuming the same methodology is used.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Jockwitz C,Mérillat S,Liem F,Oschwald J,Amunts K,Caspers S,Jäncke Ldoi
10.1002/hbm.24524subject
Has Abstractpub_date
2019-06-01 00:00:00pages
2305-2319issue
8eissn
1065-9471issn
1097-0193journal_volume
40pub_type
杂志文章abstract::In BOLD fMRI data analysis, robust and accurate estimation of the Hemodynamic Response Function (HRF) is still under investigation. Parametric methods assume the shape of the HRF to be known and constant throughout the brain, whereas non-parametric methods mostly rely on artificially increasing the signal-to-noise rat...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.10100
更新日期:2003-05-01 00:00:00
abstract::The overall goal of this work is to demonstrate how resting state functional magnetic resonance imaging (fMRI) signals may be used to objectively parcellate functionally heterogeneous subregions of the human amygdala into structures characterized by similar patterns of functional connectivity. We hypothesize that simi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22249
更新日期:2014-04-01 00:00:00
abstract::The sulcal morphology of the human frontal lobe is highly variable. Although the structural images usually acquired in functional magnetic resonance imaging studies provide information about this interindividual variability, this information is only rarely used to relate structure and function. Here, we investigated t...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20501
更新日期:2009-01-01 00:00:00
abstract::Extensive efforts are devoted to understand the functional (FC) and structural connections (SC) of the brain. FC is usually measured by functional magnetic resonance imaging (fMRI), and conceptualized as degree of synchronicity in brain activity between different regions. SC is typically indexed by measures of white m...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23403
更新日期:2017-01-01 00:00:00
abstract::Numerous daily tasks, including car driving, require fine visuospatial tuning. One such visuospatial ability, speed discrimination, declines with aging but its neural underpinnings remain unknown. In this study, we use fMRI to explore the effect of aging during a high speed discrimination task and its neural underpinn...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24240
更新日期:2018-11-01 00:00:00
abstract::Drowning is a leading cause of accidental injury and death in young children. Anoxic brain injury (ABI) is a common consequence of drowning and can cause severe neurological morbidity in survivors. Assessment of functional status and prognostication in drowning victims can be extremely challenging, both acutely and ch...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23745
更新日期:2017-10-01 00:00:00
abstract::Humans take a long time to respond to the slow visual motion of an object. It is not known what neural mechanism causes this delay. We measured magnetoencephalographic neural responses to light spot motion onset within a wide speed range (0.4-500 degrees /sec) and compared these with human reaction times (RTs). The me...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.10033
更新日期:2002-06-01 00:00:00
abstract::Landau-Kleffner syndrome (LKS) is a rare acquired aphasia occurring in otherwise healthy children, together with spike-wave discharges predominating over superior temporal regions and activated by sleep. Although the outcome of language abilities is variable, a residual impairment in verbal short-term memory (STM) is ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.10113
更新日期:2003-07-01 00:00:00
abstract::Dopaminergic degeneration is a hallmark of Parkinson's disease (PD), which causes various symptoms affected by corticostriatal circuits. So far, the relationship between cortical changes and dopamine loss in the striatum is unclear. Here, we evaluate the gray matter (GM) changes in accordance with striatal dopaminergi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23130
更新日期:2016-05-01 00:00:00
abstract::This study evaluated the neural basis of verbal working memory (WM) function in a group of 20 children and adolescents with fetal alcohol spectrum disorders (FASDs) and 20 typically developing comparison participants using functional magnetic resonance imaging (fMRI). Both groups showed prominent activation in the fro...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20741
更新日期:2009-10-01 00:00:00
abstract::There is good evidence from animal studies for segregation in the processing of non-nociceptive and nociceptive information within the trigeminal brainstem sensory nuclear complex. However, it remains unknown whether a similar segregation occurs in humans, and a recent tract tracing study suggests that this segregatio...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20805
更新日期:2009-11-01 00:00:00
abstract::Glucose transporter type I deficiency syndrome (GLUT1DS) is an encephalopathic disorder due to a chronic insufficient transport of glucose into the brain. PET studies in GLUT1DS documented a widespread cortico-thalamic hypometabolism and a signal increase in the basal ganglia, regardless of age and clinical phenotype....
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24815
更新日期:2020-02-01 00:00:00
abstract::The orbitofrontal cortex (OFC)-amygdala circuit is critical to goal-directed behavior, learning, and valuation. However, our understanding of the OFC-amygdala connections that support these emergent processes is hampered by our reliance on the primate literature and insufficient knowledge regarding the connectivity pa...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25300
更新日期:2020-12-03 00:00:00
abstract::Neuroimaging investigations consistently demonstrate that the neural processes involve complex interactions between the large-scale networks. Among those networks, the dorsal attention network (DAN) and the central-executive network (CEN) have been previously shown to exhibit anti-correlated activity with the default-...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24339
更新日期:2018-12-01 00:00:00
abstract::Theoretical models of addiction suggest that a substance use disorder represents an imbalance between hypersensitive motivational processes and deficient regulatory executive functions. Working-memory (a central executive function) may be a powerful predictor of the course of drug use and drug-related problems. Goal o...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22342
更新日期:2014-05-01 00:00:00
abstract::The influential competition between verbal and implicit systems (COVIS) model proposes that category learning is driven by two competing neural systems-an explicit, verbal, system, and a procedural-based, implicit, system. In the current fMRI study, participants learned either a conjunctive, rule-based (RB), category ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23259
更新日期:2016-10-01 00:00:00
abstract::The dynamics of the human brain span multiple spatial scales, from connectivity associated with a specific region/network to the global organization, each representing different brain mechanisms. Yet brain reconfigurations at different spatial scales are seldom explored and whether they are associated with the neural ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25205
更新日期:2021-01-01 00:00:00
abstract::Brain plasticity and memory formation depend on the expression of a large number of genes. This relationship had been studied using several experimental approaches and researchers have identified genes regulating plasticity through a variety of mechanisms. Despite this effort, a great deal remains unknown regarding th...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22592
更新日期:2014-12-01 00:00:00
abstract::It has been suggested that in humans the mirror neuron system provides a neural substrate for imitation behaviour, but the relative contributions of different brain regions to the imitation of manual actions is still a matter of debate. To investigate the role of the mirror neuron system in imitation we used fMRI to e...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20938
更新日期:2010-09-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease, which primarily targets the motor system. The structural integrity of the motor network and the way it is embedded in the overall brain network is essential for motor functioning. We studied the longitudinal effects of ALS on the brain network ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22258
更新日期:2014-04-01 00:00:00
abstract::Recent work has demonstrated that functional connectivity between remote brain regions can be modulated by task learning or the performance of an already well-learned task. Here, we investigated the extent to which initial learning and stable performance of a spatial navigation task modulates functional connectivity b...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22700
更新日期:2015-04-01 00:00:00
abstract::We studied the relationship between muscle activity (electromyography, EMG), force, and brain activity during isometric contractions of the index finger, on a group and individual level. Ten subjects contracted their right or left index finger at 5, 15, 30, 50, and 70% of their maximal force. Subjects received visual ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20388
更新日期:2008-03-01 00:00:00
abstract::Threshold-free cluster enhancement (TFCE) is a sensitive means to incorporate spatial neighborhood information in neuroimaging studies without using arbitrary thresholds. The majority of methods have applied TFCE to voxelwise data. The need to understand the relationship among multiple variables and imaging modalities...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23563
更新日期:2017-06-01 00:00:00
abstract::In day-to-day life, we need to apply strategies to cascade different actions for efficient unfolding of behavior. While deficits in action cascading are examined extensively, almost nothing is known about the neuronal mechanisms mediating superior performance above the normal level. To examine this question, we invest...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22530
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To analyze functional connectivity (FC) of the visual cortex using resting-state functional MRI in human primary open-angle glaucoma (POAG) patients. MATERIALS AND METHODS:Twenty-two patients with known POAG and 22 age-matched controls were included in this IRB-approved study. Subjects were evaluated by 3 T MR...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22079
更新日期:2013-10-01 00:00:00
abstract::There are several types of experiment in which it is useful to have subjects speak overtly in a magnetic resonance imaging (MRI) scanner, including those studying the articulatory apparatus and the neural basis of speech production, and fMRI experiments in which speech is used as a response modality. Although it is re...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20085
更新日期:2005-04-01 00:00:00
abstract::Rapid emotion processing is an ecologically essential ability for survival in social environments in which threatening or advantageous encounters dynamically and rapidly occur. Efficient emotion recognition is subserved by different processes, depending on one's expectations; however, the underlying functional and str...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24779
更新日期:2019-12-15 00:00:00
abstract::Electrophysiological signals recorded intracranially show rich frequency content spanning from near-DC to hundreds of hertz. Noninvasive electromagnetic signals measured with electroencephalography (EEG) or magnetoencephalography (MEG) typically contain less signal power in high frequencies than invasive recordings. P...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24795
更新日期:2020-01-01 00:00:00
abstract::Neurodegenerative diseases such as Alzheimer's disease (AD) have been recognized to exhibit disease-specific brain vulnerability patterns. Apolipoprotein E (APOE) ɛ4 allele imparts a high genetic risk of developing AD. Whether the APOE ɛ4 allele damages the brain when cognitive functions are still intact is important ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23359
更新日期:2017-01-01 00:00:00
abstract::Classically, model-based segmentation procedures match magnetic resonance imaging (MRI) volumes to an expertly labeled atlas using nonlinear registration. The accuracy of these techniques are limited due to atlas biases, misregistration, and resampling error. Multi-atlas-based approaches are used as a remedy and invol...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22092
更新日期:2013-10-01 00:00:00