Abstract：
:Voxel-based analyses (VBA) are increasingly being used to detect white matter abnormalities with diffusion tensor imaging (DTI) in different types of pathologies. However, the validity, specificity, and sensitivity of statistical inferences of group differences to a large extent depend on the quality of the spatial normalization of the DTI images. Using high-dimensional nonrigid coregistration techniques that are able to align both the spatial and orientational diffusion information and incorporate appropriate templates that contain this complete DT information may improve this quality. Alternatively, a hybrid technique such as tract-based spatial statistics (TBSS) may improve the reliability of the statistical results by generating voxel-wise statistics without the need for perfect image alignment and spatial smoothing. In this study, we have used (1) a coregistration algorithm that was optimized for coregistration of DTI data and (2) a population-based DTI atlas to reanalyze our previously published VBA, which compared the fractional anisotropy and mean diffusivity maps of patients with amyotrophic lateral sclerosis (ALS) with those of healthy controls. Additionally, we performed a complementary TBSS analysis to improve our understanding and interpretation of the VBA results. We demonstrate that, as the overall variance of the diffusion properties is lowered after normalizing the DTI data with such recently developed techniques (VBA using our own optimized high-dimensional nonrigid coregistration and TBSS), more reliable voxel-wise statistical results can be obtained than had previously been possible, with our VBA and TBSS yielding very similar results. This study provides support for the view of ALS as a multisystem disease, in which the entire frontotemporal lobe is implicated.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Sage CA,Van Hecke W,Peeters R,Sijbers J,Robberecht W,Parizel P,Marchal G,Leemans A,Sunaert Sdoi
10.1002/hbm.20794subject
Has Abstractpub_date
2009-11-01 00:00:00pages
3657-75issue
11eissn
1065-9471issn
1097-0193journal_volume
30pub_type
杂志文章abstract：:We describe a system that localizes a single dipole to reasonable accuracy from noisy magnetoencephalographic (MEG) measurements in real time. At its core is a multilayer perceptron (MLP) trained to map sensor signals and head position to dipole location. Including head position overcomes the previous need to retrain ...
journal_title：Human brain mapping
pub_type： 杂志文章
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更新日期：2005-01-01 00:00:00
abstract：:The present study investigates human visual processing of simple two-colour patterns using a delayed match to sample paradigm with positron emission tomography (PET). This study is unique in that we specifically designed the visual stimuli to be the same for both pattern and colour recognition with all patterns being ...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：
更新日期：2001-08-01 00:00:00
abstract：:We report an automated method to simultaneously monitor blood-oxygenation-level-dependent (BOLD) MR signals from multiple cortical areas in real-time. Individual brain anatomy was normalized and registered to a pre-segmented atlas in standardized anatomical space. Subsequently, using real-time fMRI (rtfMRI) data acqui...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.20377
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abstract：:Huntington's disease (HD) is a neurodegenerative disorder which is primarily associated with striatal degeneration. However, the alterations in connectivity of this structure in HD have been underinvestigated. In this study, we analyzed the functional and structural connectivity of the left putamen, while participants...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.23813
更新日期：2018-01-01 00:00:00
abstract：:Carpal tunnel syndrome (CTS) is a common entrapment neuropathy of the median nerve characterized by paresthesias and pain in the first through fourth digits. We hypothesize that aberrant afferent input from CTS will lead to maladaptive cortical plasticity, which may be corrected by appropriate therapy. Functional MRI ...
journal_title：Human brain mapping
pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.20067
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.22792
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.22322
更新日期：2014-05-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1002/hbm.22530
更新日期：2014-10-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.21446
更新日期：2013-02-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.23124
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pub_type： 杂志文章
doi：10.1002/hbm.24533
更新日期：2019-06-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.23574
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journal_title：Human brain mapping
pub_type： 杂志文章,meta分析
doi：10.1002/hbm.24747
更新日期：2019-12-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.20619
更新日期：2009-05-01 00:00:00
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journal_title：Human brain mapping
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1998-01-01 00:00:00
abstract：:Cognitive dysfunction is common in patients with multiple sclerosis (MS). Saccadic eye movement paradigms such as antisaccades (AS) can sensitively interrogate cognitive function, in particular, the executive and attentional processes of response selection and inhibition. Although we have previously demonstrated signi...
journal_title：Human brain mapping
pub_type： 杂志文章
doi：10.1002/hbm.22329
更新日期：2014-05-01 00:00:00
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journal_title：Human brain mapping
pub_type： 杂志文章
doi：
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pub_type： 杂志文章
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journal_title：Human brain mapping
pub_type： 杂志文章,meta分析
doi：10.1002/hbm.23895
更新日期：2018-02-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Human brain mapping
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-01-01 00:00:00
