Abstract:
:In this study we demonstrate that the pattern of an amygdala-centric network contributes to individual differences in trait anxiety. Individual differences in trait anxiety were predicted using maximum likelihood estimates of amygdala structural connectivity to multiple brain targets derived from diffusion-tensor imaging (DTI) and probabilistic tractography on 72 participants. The prediction was performed using a stratified sixfold cross validation procedure using a regularized least square regression model. The analysis revealed a reliable network of regions predicting individual differences in trait anxiety. Higher trait anxiety was associated with stronger connections between the amygdala and dorsal anterior cingulate cortex, an area implicated in the generation of emotional reactions, and inferior temporal gyrus and paracentral lobule, areas associated with perceptual and sensory processing. In contrast, higher trait anxiety was associated with weaker connections between amygdala and regions implicated in extinction learning such as medial orbitofrontal cortex, and memory encoding and environmental context recognition, including posterior cingulate cortex and parahippocampal gyrus. Thus, trait anxiety is not only associated with reduced amygdala connectivity with prefrontal areas associated with emotion modulation, but also enhanced connectivity with sensory areas. This work provides novel anatomical insight into potential mechanisms behind information processing biases observed in disorders of emotion.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Greening SG,Mitchell DGdoi
10.1002/hbm.22952subject
Has Abstractpub_date
2015-12-01 00:00:00pages
4819-30issue
12eissn
1065-9471issn
1097-0193journal_volume
36pub_type
杂志文章abstract:OBJECTIVE:To determine the functional connectivity of different EEG bands at the "baseline" situation (rest) and during mathematical thinking in children and young adults to study the maturation effect on brain networks at rest and during a cognitive task. METHODS:Twenty children (8-12 years) and twenty students (21-2...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20492
更新日期:2009-01-01 00:00:00
abstract::Studies of cognitive function that compare the blood oxygenation level dependent (BOLD) signal across age groups often require the assumption that neurovascular coupling does not change with age. Tests of this assumption have produced mixed results regarding the strength of the coupling and its relative time course. U...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23608
更新日期:2017-07-01 00:00:00
abstract::We systematically investigated the effects of cathodal and anodal Transcranial Direct Current Stimulation (CtDCS, AtDCS) on the electric activity of primary motor cortex during a motor task. High-density electroencephalography was used to define the spatial diffusion of tDCS after effects. Ten healthy subjects perform...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22322
更新日期:2014-05-01 00:00:00
abstract::Months, days of the week, and numbers differ from other verbal concepts because they are ordered in a sequence, whereas no order is imposed on members of other categories, such as animals or tools. Recent studies suggest that numbers activate a representation of their quantity within the intraparietal sulcus (IPS) aut...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20433
更新日期:2008-08-01 00:00:00
abstract::In daily life, we permanently need to adapt our behavior to new task situations, requiring cognitive control. Such adaptive processes are commonly investigated with the task-switching paradigm. Many fMRI studies have interpreted stronger activation for switch than repeat trials in fronto-parietal brain areas as reflec...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21234
更新日期:2012-03-01 00:00:00
abstract::Extensive efforts are devoted to understand the functional (FC) and structural connections (SC) of the brain. FC is usually measured by functional magnetic resonance imaging (fMRI), and conceptualized as degree of synchronicity in brain activity between different regions. SC is typically indexed by measures of white m...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23403
更新日期:2017-01-01 00:00:00
abstract:UNLABELLED:Major depression has been repeatedly associated with amygdala hyper-responsiveness to negative (but not positive) facial expressions at early, automatic stages of emotion processing using subliminally presented stimuli. However, it is not clear whether this "limbic bias" is a correlate of depression or repre...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22112
更新日期:2013-11-01 00:00:00
abstract::Cognitive dysfunction is common in patients with multiple sclerosis (MS). Saccadic eye movement paradigms such as antisaccades (AS) can sensitively interrogate cognitive function, in particular, the executive and attentional processes of response selection and inhibition. Although we have previously demonstrated signi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22329
更新日期:2014-05-01 00:00:00
abstract::The development of treatments for attention impairments is hampered by limited knowledge about the malleability of underlying neural functions. We conducted the first randomized controlled trial to determine the modulations of brain activity associated with working memory (WM) training in adults with attention-deficit...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25164
更新日期:2020-12-01 00:00:00
abstract::The cumulative effects of repetitive subclinical head impacts during sports may result in chronic white matter (WM) changes and possibly, neurodegenerative sequelae. In this pilot study, we investigated the longitudinal WM changes over the course of two consecutive high-school football seasons and explored the long-te...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23859
更新日期:2018-01-01 00:00:00
abstract::Voluntary movements require control of multiple kinematic parameters, a task carried out by a distributed brain architecture. However, it remains unclear whether regions along the motor system encode single, or rather a mixture of, kinematic parameters during action execution. Here, rapid event-related functional magn...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23802
更新日期:2017-12-01 00:00:00
abstract::The cingulum bundle is a white matter fiber bundle in the human brain that is believed to be implicated in various neurological and psychiatric diseases. Subtle disease-related differences in metabolite concentrations in the cingulum tracts that may underlie these diseases may be detected using MR spectroscopic inform...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21302
更新日期:2012-07-01 00:00:00
abstract::Movement execution strongly relies on precise sensorimotor synchronization. In a finger-tapping task that requires subjects to synchronize their finger taps to regular pacing signal synchronization accuracy varies with respect to pacing signal's modality. This study aimed at elucidating functional brain dynamics assoc...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20762
更新日期:2009-06-01 00:00:00
abstract::Own body perception, and differentiating and comparing one's body to another person's body, are common cognitive functions that have relevance for self-identity and social interactions. In several psychiatric conditions, including anorexia nervosa, body dysmorphic disorder, gender dysphoria, and autism spectrum disord...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24388
更新日期:2019-02-01 00:00:00
abstract::During the developmental stage, the brain undergoes anatomic, functional, and metabolic changes necessary to support the complex adaptive behavior of a mature individual. Estimation of developmental changes occurring in different regions of the brain would provide a means of relating various behavioral phenomena to ma...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20020
更新日期:2004-06-01 00:00:00
abstract::Previous studies have shown that white matter in the deaf brain changes due to hearing loss. However, how white-matter development is influenced by early hearing experience of deaf people is still unknown. Using diffusion tensor imaging and tract-based spatial statistics, we compared white-matter structures among thre...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21215
更新日期:2012-02-01 00:00:00
abstract::There is still no clear consensus as to which of the many functional and structural changes in the brain in schizophrenia are of most importance, although the main focus to date has been on those in the frontal and cingulate cortices. In the present study, we have used a novel holistic approach to identify brain-wide ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22162
更新日期:2014-01-01 00:00:00
abstract::In the absence of vision, spatial representation may be altered. When asked to compare the relative distances between three sounds (i.e., auditory spatial bisection task), blind individuals demonstrate significant deficits and do not show an event-related potential response mimicking the visual C1 reported in sighted ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24931
更新日期:2020-06-01 00:00:00
abstract::Mathematical word problems are ubiquitous and standard for teaching and evaluating generalization of mathematical knowledge for real-world contexts. It is therefore concerning that the neural mechanisms of word problem solving are not well understood, as these insights represent strong potential for improving educatio...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24502
更新日期:2019-04-15 00:00:00
abstract::During the last 20 years, predictive modeling in epilepsy research has largely been concerned with the prediction of seizure events, whereas the inference of effective brain targets for resective surgery has received surprisingly little attention. In this exploratory pilot study, we describe a distributional clusterin...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23537
更新日期:2017-05-01 00:00:00
abstract::We report an automated method to simultaneously monitor blood-oxygenation-level-dependent (BOLD) MR signals from multiple cortical areas in real-time. Individual brain anatomy was normalized and registered to a pre-segmented atlas in standardized anatomical space. Subsequently, using real-time fMRI (rtfMRI) data acqui...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20377
更新日期:2008-02-01 00:00:00
abstract::The default-mode network (DMN) is a set of specific brain regions whose activity, predominant in the resting-state, is attenuated during cognitively demanding, externally-cued tasks. The cognitive correlates of this network have proven difficult to interrogate, but one hypothesis is that regions in the network process...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20537
更新日期:2008-07-01 00:00:00
abstract::Synchrony measurements of spontaneous low-frequency blood oxygenation level-dependent (BOLD) fluctuations are increasingly being used to investigate spatial regions of functional connectivity. Although information regarding BOLD-BOLD synchrony between different regions is frequently reported, the relationship between ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21228
更新日期:2012-03-01 00:00:00
abstract::We describe a functional neuroanatomy approach that combines structural (MRI) and functional (PET) data at the individual level. For each subject MRI dataset, sulci are first localized using hemisphere surface rendering and sections and stored. Using these landmarks, the subject brain volume is then divided in 100 ana...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0193(1997)5:4<228::AID-HBM4>3.0
更新日期:1997-01-01 00:00:00
abstract::In functional magnetic resonance imaging (fMRI) research one is typically interested in neural activity. However, the blood-oxygenation level-dependent (BOLD) signal is a composite of both neural and vascular activity. As factors such as age or medication may alter vascular function, it is essential to account for cha...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22768
更新日期:2015-06-01 00:00:00
abstract::The role of the right hemisphere (RH) in metaphor comprehension is still controversial. Numerous neuroimaging studies have found that conventionality, sentential context, and task demand can influence the involvement of the RH in metaphor processing. The current meta-analysis used foci from 17 original functional magn...
journal_title:Human brain mapping
pub_type: 杂志文章,meta分析
doi:10.1002/hbm.22160
更新日期:2014-01-01 00:00:00
abstract::One of the major findings from multimodal neuroimaging studies in the past decade is that the human brain is anatomically and functionally organized into large-scale networks. In resting state fMRI (rs-fMRI), spatial patterns emerge when temporal correlations between various brain regions are tallied, evidencing netwo...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22865
更新日期:2015-09-01 00:00:00
abstract::One of our highest evolved functions as human beings is our capacity to switch between multiple tasks effectively. A body of research has identified a distributed frontoparietal network of brain regions which contribute to task switching. However, relatively less is known about whether some brain regions may contribut...
journal_title:Human brain mapping
pub_type: 杂志文章,meta分析
doi:10.1002/hbm.21199
更新日期:2012-01-01 00:00:00
abstract::We demonstrate that multivoxel pattern analysis can be used to decode place-related information in fMRI. Subjects performed a working memory version of the Morris water maze task in a virtual environment with a single wall cue. The voxel data that corresponds to when subjects were located at the goal was extracted for...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20873
更新日期:2010-03-01 00:00:00
abstract::Individuals with a constitutional chromosome abnormality consisting of a deletion of a portion of the long arm of chromosome 18 (18q-) have a high incidence ( approximately 95%) of dysmyelination. Neuroradiologic findings in affected children report a smaller corpus callosum, but this finding has not been quantified. ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20090
更新日期:2005-04-01 00:00:00