Abstract:
:Anxiety arising during pain expectancy can modulate the subjective experience of pain. However, individuals differ in their sensitivity to pain expectancy. The amygdale and hippocampus were proposed to mediate the behavioral response to aversive stimuli. However, their differential role in mediating anxiety-related individual differences is not clear. Using fMRI, we investigated brain activity during expectancy to cued or uncued thermal pain applied to the wrist. Following each stimulation participants rated the intensity of the painful experience. Activations in the amygdala and hippocampus were examined with respect to individual differences in harm avoidance (HA) personality trait, and individual sensitivity to expectancy, (i.e. response to cued vs. uncued painful stimuli). Only half of the subjects reported on cued pain as being more painful than uncued pain. In addition, we found a different activation profile for the amygdala and hippocampus during pain expectancy and experience. The amygdala was more active during expectancy and this activity was correlated with HA scores. The hippocampal activity was equally increased during both pain expectancy and experience, and correlated with the individual's sensitivity to expectancy. Our findings suggest that the amygdala supports an innate tendency to approach or avoid pain as reflected in HA trait, whereas the hippocampus mediates the effect of context possibly via appraisal of the stimulus value.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Ziv M,Tomer R,Defrin R,Hendler Tdoi
10.1002/hbm.20867subject
Has Abstractpub_date
2010-02-01 00:00:00pages
326-38issue
2eissn
1065-9471issn
1097-0193journal_volume
31pub_type
杂志文章abstract::A large body of behavioural research has used the cued task-switching paradigm to characterize the nature of trial-by-trial preparatory adjustments that enable fluent task implementation when demands on cognitive flexibility are high. This work reviews the growing number of fMRI studies on the same topic, mostly focus...
journal_title:Human brain mapping
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23188
更新日期:2016-07-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20146
更新日期:2005-10-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21450
更新日期:2013-02-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22383
更新日期:2014-07-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24375
更新日期:2019-01-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21104
更新日期:2011-08-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20646
更新日期:2009-07-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23910
更新日期:2018-03-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/hbm.20694
更新日期:2009-08-01 00:00:00
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更新日期:2001-09-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22128
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:Memory impairment is one of the most prominent cognitive deficits in temporal lobe epilepsy (TLE). The overall goal of this study was to explore the contribution of cortical and hippocampal (subfield) damage to impairment of auditory immediate recall (AIMrecall), auditory delayed recall (ADMrecall), and audi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21226
更新日期:2012-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/hbm.20815
更新日期:2009-12-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22935
更新日期:2015-11-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21302
更新日期:2012-07-01 00:00:00
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journal_title:Human brain mapping
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/hbm.23664
更新日期:2017-09-01 00:00:00