Abstract:
:The human gustatory cortex analyzes the chemosensory properties of tastants, particularly the quality, intensity, and affective valence, to determine whether a perceived substance should be ingested or rejected. Among previous studies, the spatial distribution of taste intensity-related activations within the human insula has been scarcely addressed. To spatially characterize a specialized or distributed nature of the cortical responses to taste intensities, a functional magnetic resonance imaging study was performed at 3 T in 44 healthy subjects where sweet and bitter tastants were administered at five increasing concentrations and cortex-based factorial and parametric analyses were performed. Two clusters in the right middle-posterior and left middle insula were found specialized for taste intensity processing, exhibiting a highly nonlinear profile across concentrations. Multiple clusters were found activated by sweet and bitter taste stimuli at most concentrations, in the anterior, middle-posterior, and inferior portion of the bilateral insula. Across these clusters, respectively, for the right and left insula, a superior-to-inferior and an anterior-to-posterior spatial gradient for high-to-low concentrations were observed for the most responsive intensity of both tastes. These findings may gather new insights regarding how the gustatory cortex is spatially organized during the perceptual processing of taste intensity for two basic tastants.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Canna A,Prinster A,Cantone E,Ponticorvo S,Russo AG,Di Salle F,Esposito Fdoi
10.1002/hbm.24621subject
Has Abstractpub_date
2019-08-15 00:00:00pages
3631-3646issue
12eissn
1065-9471issn
1097-0193journal_volume
40pub_type
杂志文章abstract::Research in amyotrophic lateral sclerosis (ALS) suggests that executive dysfunction, a prevalent cognitive feature of the disease, is associated with abnormal structural connectivity and white matter integrity. In this exploratory study, we investigated the white matter constructs of executive dysfunction, and attempt...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23452
更新日期:2017-03-01 00:00:00
abstract::Recent studies have shown that resting-state functional networks as studied with fMRI, EEG, and MEG may be so-called small-world networks. We investigated to what extent the characteristic features of small-world networks are genetically determined. To represent functional connectivity between brain areas, we measured...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20468
更新日期:2008-12-01 00:00:00
abstract::Recent work has demonstrated that functional connectivity between remote brain regions can be modulated by task learning or the performance of an already well-learned task. Here, we investigated the extent to which initial learning and stable performance of a spatial navigation task modulates functional connectivity b...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22700
更新日期:2015-04-01 00:00:00
abstract::Glucose transporter type I deficiency syndrome (GLUT1DS) is an encephalopathic disorder due to a chronic insufficient transport of glucose into the brain. PET studies in GLUT1DS documented a widespread cortico-thalamic hypometabolism and a signal increase in the basal ganglia, regardless of age and clinical phenotype....
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24815
更新日期:2020-02-01 00:00:00
abstract::Alterations in resting-state networks (RSNs) are often associated with psychiatric and neurologic disorders. Given this critical linkage, it has been hypothesized that RSNs can potentially be used as endophenotypes for brain diseases. To validate this notion, a critical step is to show that RSNs exhibit heritability. ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22890
更新日期:2015-10-01 00:00:00
abstract::Both increases and decreases in resting state functional connectivity have been previously observed within the motor network during aging. Moreover, the relationship between altered functional connectivity and age-related declines in bimanual coordination remains unclear. Here, we explored the developmental dynamics o...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22450
更新日期:2014-08-01 00:00:00
abstract::A diffusion-weighted (DW) template in a standard coordinate system is often necessary for the analysis of white matter (WM) structures using DW images. Although several DW templates have been constructed in the ICBM-152 space, a template for diffusion spectrum imaging (DSI) is still lacking. In this study, we develope...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22860
更新日期:2015-09-01 00:00:00
abstract::Imagination and creative cognition are often associated with the brain's default network (DN). Recent evidence has also linked cognitive control systems to performance on tasks involving imagination and creativity, with a growing number of studies reporting functional interactions between cognitive control and DN regi...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23884
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Cognitive dysfunction is considered a core feature of schizophrenia, and impaired performances in episodic memory (EM) and executive function (EF) tasks are consistently reported in schizophrenia patients. Traditional fMRI and EEG studies have helped identifying brain areas, including the prefrontal cortex (...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22935
更新日期:2015-11-01 00:00:00
abstract::Word production is a complex multistage process linking conceptual representations, lexical entries, phonological forms and articulation. Previous studies have revealed a network of predominantly left-lateralized brain regions supporting this process, but many details regarding the precise functions of different nodes...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20782
更新日期:2009-11-01 00:00:00
abstract::The presence of white matter lesions in patients with cerebral small vessel disease (SVD) is among the main causes of cognitive decline. We investigated the relation between white matter hyperintensity (WMH) locations and executive and language abilities in 442 SVD patients without dementia with varying burden of WMH....
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25273
更新日期:2020-11-24 00:00:00
abstract::Metabolic markers of baseline brain oxygenation and tissue perfusion have an important role to play in the early identification of ischaemic tissue in acute stroke. Although well established MRI techniques exist for mapping brain perfusion, quantitative imaging of brain oxygenation is poorly served. Streamlined-qBOLD ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24564
更新日期:2019-07-01 00:00:00
abstract::Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that alters cortical excitability and activity in a polarity-dependent way. Stimulation for few minutes has been shown to induce plastic alterations of cortical excitability and to improve cognitive performance. These effects m...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21104
更新日期:2011-08-01 00:00:00
abstract::It is becoming common to collect data from multiple functional magnetic resonance imaging (fMRI) paradigms on a single individual. The data from these experiments are typically analyzed separately and sometimes directly subtracted from one another on a voxel-by-voxel basis. These comparative approaches, although usefu...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.20204
更新日期:2006-07-01 00:00:00
abstract::The functional organization of the human brain consists of a high degree of connectivity between interhemispheric homologous regions. The degree of homotopic organization is known to vary across the cortex and homotopic connectivity is high in regions that share cross-hemisphere structural connections or are activated...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23214
更新日期:2016-08-01 00:00:00
abstract::We systematically investigated the effects of cathodal and anodal Transcranial Direct Current Stimulation (CtDCS, AtDCS) on the electric activity of primary motor cortex during a motor task. High-density electroencephalography was used to define the spatial diffusion of tDCS after effects. Ten healthy subjects perform...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22322
更新日期:2014-05-01 00:00:00
abstract::Deficits in information processing speed (IPS) are among the earliest and most prominent cognitive manifestations in mild traumatic brain injury (mTBI). We investigated the impact of white matter fiber location on IPS outcome in an individual basis assessment. A total of 112 acute mild TBI with all CT negative underwe...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.25135
更新日期:2020-07-13 00:00:00
abstract::It has recently been demonstrated that specific patterns of correlation exist in diffusion tensor imaging (DTI) parameters across white matter tracts in the normal human brain. These microstructural correlations are thought to reflect phylogenetic and functional similarities between different axonal fiber pathways. Ho...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21292
更新日期:2012-06-01 00:00:00
abstract::Affective temperaments have been described since the early 20th century and may play a central role in psychiatric illnesses, such as bipolar disorder (BD). However, the neuronal basis of temperament is still unclear. We investigated the relationship of temperament with neuronal variability in the resting state signal...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24453
更新日期:2019-03-01 00:00:00
abstract::Previous structural and functional neuroimaging studies have implicated distributed brain regions and networks in depression. However, there are no robust imaging biomarkers that are specific to depression, which may be due to clinical heterogeneity and neurobiological complexity. A dimensional approach and fusion of ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24802
更新日期:2020-01-01 00:00:00
abstract::Maintaining alertness is critical for safe and successful performance of most human activities. Consequently, microsleeps during continuous visuomotor tasks, such as driving, can be very serious, not only disrupting performance but sometimes leading to injury or death due to accidents. We have investigated the neural ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22178
更新日期:2014-01-01 00:00:00
abstract::MR-based measurements of brain volumes may be affected by the presence of white matter (WM) lesions. Here, we assessed how and to what extent this may happen for WM lesions of various sizes and intensities. After inserting WM lesions of different sizes and intensities into T1-W brain images of healthy subjects, we ass...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.21344
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intravascular angioplasty and stenting of intracranial arterial stenosis provided controversial results. Besides the expertise of the practitioners, the selection of the patients remains challenging. BOLD MRI of the cerebral vasoreactivity (BOLD MRI CVR) to hypercapnia provides reproducible maps ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22255
更新日期:2014-04-01 00:00:00
abstract::One of the major findings from multimodal neuroimaging studies in the past decade is that the human brain is anatomically and functionally organized into large-scale networks. In resting state fMRI (rs-fMRI), spatial patterns emerge when temporal correlations between various brain regions are tallied, evidencing netwo...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22865
更新日期:2015-09-01 00:00:00
abstract::The Disrupted in Schizophrenia Gene 1 (DISC1) plays a role in both neural signaling and development and is associated with schizophrenia, although its links to altered brain structure and function in this disorder are not fully established. Here we have used structural and functional MRI to investigate links with six ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22560
更新日期:2014-11-01 00:00:00
abstract::Healthy aging is accompanied by a constellation of changes in cognitive processes and alterations in functional brain networks. The relationships between brain networks and cognition during aging in later life are moderated by demographic and environmental factors, such as prior education, in a poorly understood manne...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23717
更新日期:2017-10-01 00:00:00
abstract::While behavioral research suggests an association between cultural worldview and decreased anxiety of death, the underlying neurobiological mechanisms remain unclear. Using functional MRI, we investigated whether and how the serotonin transporter promoter polymorphism (5-HTTLPR), which has been associated with mental ...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23819
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To assess the structural correlates of cognitive and behavioral impairment in motor neuron diseases (MND) using multimodal MRI. METHODS:One hundred one patients with sporadic MND (56 classic amyotrophic lateral sclerosis, 31 upper motor neuron phenotype, and 14 lower motor neuron phenotype) and 51 controls w...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23124
更新日期:2016-04-01 00:00:00
abstract::Electrophysiological signals from the cerebellum have traditionally been viewed as inaccessible to magnetoencephalography (MEG) and electroencephalography (EEG). Here, we challenge this position by investigating the ability of MEG and EEG to detect cerebellar activity using a model that employs a high-resolution tesse...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.24951
更新日期:2020-06-15 00:00:00
abstract::Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF) and between-subject variation of Hct thus causes variation in task-based BOLD fMRI signal changes. We first verified in healthy volunteers (n = 12) that Hct values can be derived reliably from venous blood T1 values by compariso...
journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.23846
更新日期:2018-01-01 00:00:00