Cytotoxic effects of contemporary bulk-fill dental composites: A real-time cell analysis.

Abstract:

:The aim of this study was to evaluate the cytotoxicity of contemporary flowable and paste-like bulk-fill dental composites by using a real-time cell analysis. In the present paper, cytotoxicity levels of five flowable, five paste-like bulk-fill composite materials and one conventional flowable, one conventional paste-like resin composite were examined on L929 mouse fibroblast cell line. After seeding 25,000 cells/300 μL/well cell suspensions into the wells of an E-plate, test materials were added and observed at every 30 min intervals for 72 h. Kruskal Wallis H and Mann Whitney U multiple comparison tests were used to analyze the results. Pre-reacted glass-ionomer (PRG) containing bulk-fill composites were severely toxic at all time points (24, 48 and 72 h, p<0.05). None of the tested composites demonstrated high cell viability (>70%) at 48 and 72 h. Flowable and paste-like composites of the same brand exhibited similar cytotoxic properties (p>0.05).

journal_name

Dent Mater J

journal_title

Dental materials journal

authors

Demirel G,Gür G,Demirsoy FF,Altuntaş EG,Yener-Ilce B,Kiliçarslan MA

doi

10.4012/dmj.2018-336

subject

Has Abstract

pub_date

2020-01-31 00:00:00

pages

101-110

issue

1

eissn

0287-4547

issn

1881-1361

journal_volume

39

pub_type

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