Abstract:
:We aimed to establish an experimental animal model to evaluate materials for endodontic therapy. We focused on the biocompatibility of new paste-type zinc oxide-eugenol (ZOE) sealer. The results of this sealer were compared with those of conventional powder/liquid ZOE and eugenol-free sealers. The molars of Wistar rats were extracted and repositioned in the original socket after application of the sealers on the root apices. Mild inflammation occurred in the periapical tissue of the replanted teeth with both ZOE sealers on day 7, whereas the eugenol-free sealer induced severe inflammation. On day 14, the lesions induced by all types of sealers were healed and replaced predominantly by fibrous connective tissue. Thus, all endodontic materials showed high biocompatibility, although the extent of inflammatory reactions during the early stages varied depending on the types of materials. We demonstrated that our animal model was useful for the assessment of the biocompatibility of endodontic materials.
journal_name
Dent Mater Jjournal_title
Dental materials journalauthors
Mutoh N,Tani-Ishii Ndoi
10.4012/dmj.2010-095subject
Has Abstractpub_date
2011-01-01 00:00:00pages
176-82issue
2eissn
0287-4547issn
1881-1361pii
JST.JSTAGE/dmj/2010-095journal_volume
30pub_type
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