A biocompatible model for evaluation of the responses of rat periapical tissue to a new zinc oxide-eugenol sealer.

Abstract:

:We aimed to establish an experimental animal model to evaluate materials for endodontic therapy. We focused on the biocompatibility of new paste-type zinc oxide-eugenol (ZOE) sealer. The results of this sealer were compared with those of conventional powder/liquid ZOE and eugenol-free sealers. The molars of Wistar rats were extracted and repositioned in the original socket after application of the sealers on the root apices. Mild inflammation occurred in the periapical tissue of the replanted teeth with both ZOE sealers on day 7, whereas the eugenol-free sealer induced severe inflammation. On day 14, the lesions induced by all types of sealers were healed and replaced predominantly by fibrous connective tissue. Thus, all endodontic materials showed high biocompatibility, although the extent of inflammatory reactions during the early stages varied depending on the types of materials. We demonstrated that our animal model was useful for the assessment of the biocompatibility of endodontic materials.

journal_name

Dent Mater J

journal_title

Dental materials journal

authors

Mutoh N,Tani-Ishii N

doi

10.4012/dmj.2010-095

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

176-82

issue

2

eissn

0287-4547

issn

1881-1361

pii

JST.JSTAGE/dmj/2010-095

journal_volume

30

pub_type

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