The protective effect of resveratrol against dentin bonding agents-induced cytotoxicity.

Abstract:

:This study was designed to evaluate the cytotoxicity of four dentin bonding agents and the effects of an antioxidant addition. Group A: G-aenial Bond, Group B: Optibond All in One, Group C: Gluma Self Etch and Group D: Clearfil S(3) Bond were added to the medium using extract method. The cells were cultured with or without resveratrol (RES) addition. MTT, reactive oxygen species (ROS), DCF, Comet and 8-OHdG measurements were performed. The agents had a dose-dependent (1:1>1:10>1:20) cytotoxic effect. Considering 1:10 concentration; Group D at 1 h (p<0.01) and Group B and D at 24 h had the weakest cytotoxic effect (p<0.05). After RES addition, the highest cell viability was determined in Groups B+RES and D+RES at 1 h and in Groups A+RES and B+RES at 24 h (p<0.01). The dentin bonding agents induced ROS production and DNA damage regarding to their composition. However, RES addition decreased the indicated parameters.

journal_name

Dent Mater J

journal_title

Dental materials journal

authors

Atalayin C,Armagan G,Konyalioglu S,Kemaloglu H,Tezel H,Ergucu Z,Keser A,Dagci T,Onal B

doi

10.4012/dmj.2015-079

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

766-73

issue

6

eissn

0287-4547

issn

1881-1361

journal_volume

34

pub_type

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