Abstract:
:As more and more cell and gene therapies are being developed and with the increasing number of regulatory approvals being obtained, there is an emerging and pressing need for industrial translation. Process efficiency, associated cost drivers and regulatory requirements are issues that need to be addressed before industrialisation of cell and gene therapies can be established. Automation has the potential to address these issues and pave the way towards commercialisation and mass production as it has been the case for 'classical' production industries. This review provides an insight into how automation can help address the manufacturing issues arising from the development of large-scale manufacturing processes for modern cell and gene therapy. The existing automated technologies with applicability in cell and gene therapy manufacturing are summarized and evaluated here.
journal_name
Biotechnol Lettjournal_title
Biotechnology lettersauthors
Moutsatsou P,Ochs J,Schmitt RH,Hewitt CJ,Hanga MPdoi
10.1007/s10529-019-02732-zsubject
Has Abstractpub_date
2019-11-01 00:00:00pages
1245-1253issue
11eissn
0141-5492issn
1573-6776pii
10.1007/s10529-019-02732-zjournal_volume
41pub_type
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