Abstract:
:Peroxisome proliferator-activated receptors (PPARs) alpha and gamma are key regulators of lipid homeostasis and insulin resistance. In this study we show that a novel compound, 3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}- 2-[2-(2-nitro-phenoxy)-acetyl amino]-propionic acid (O325H), is an agonist with dual effect on PPARalpha/gamma by using dual-luciferase reporter gene assay. By activating PPARalpha and PPARgamma simultaneously, O325H promotes pre-adipocyte differentiation and up-regulates the expression of glucose and lipid metabolic target genes. In diabetic mice, administration of O325H at 10 mg/kg decreases the blood lipid and glucose levels. Therefore, O325H has dual action on PPARalpha and PPARgamma and is a promising agent for the amelioration of lipid metabolic disorders and diabetes associated with insulin resistance.
journal_name
Biotechnol Lettjournal_title
Biotechnology lettersauthors
Xu C,Wang LL,Liu HY,Ruan CM,Zhou XB,Cao YL,Li Sdoi
10.1007/s10529-006-9013-ysubject
Has Abstractpub_date
2006-06-01 00:00:00pages
863-8issue
12eissn
0141-5492issn
1573-6776journal_volume
28pub_type
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pub_type: 杂志文章,评审
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pub_type: 历史文章,杂志文章,评审
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pub_type: 杂志文章
doi:10.1007/s10529-008-9674-9
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doi:10.1007/s10529-018-2556-x
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pub_type: 杂志文章
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doi:10.1007/s10529-010-0284-y
更新日期:2010-09-01 00:00:00
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