Abstract:
BACKGROUND:Diabetes is a risk factor for various cancers, but its prognostic role in renal cell carcinoma (RCC) is controversial and understudied. This study investigated the prognostic value of type 2 diabetes (T2D) in RCC patients. METHODS:The clinicopathological and follow-up data of 451 RCC patients undergoing radical or partial nephrectomy at the First Hospital of Shanxi Medical University from 2013 to 2018 were reviewed. Associations of T2D with clinicopathological parameters of RCC were evaluated using the Kaplan-Meier method for survival estimates and Cox regression univariate and multivariate analyses. RESULTS:Of 451 patients, 74 (16.4%) had T2D. These patients were older, had a higher body mass index, higher incidence rates of hypertension and cardiovascular morbidity, a higher rate of laparoscopic surgery, and smaller neoplasms (all P < .05). Patients with T2D exhibited shorter overall survival (OS; P = .009), cancer-specific survival (CSS; P = .043), and recurrence-free survival (RFS; P = .008) than patients without T2D. Fuhrman grade (hazard ratio [HR] 2.542, 95% confidence interval [CI] 1.115-5.795, P = .026) and T2D (HR 3.391, CI 1.458-7.886, P = .005) were independent predictors of OS; T2D was an independent predictor of CSS (HR = 4.637, 95% CI 1.420-15.139, P = .011) and RFS (HR 3.492, 95% CI 1.516-8.044, P = .003). CONCLUSIONS:Renal cell carcinoma patients with T2D have a shorter OS and higher recurrence rate and mortality risk than those without T2D. :背景: 糖尿病是多种癌症的危险因素, 但其在肾细胞癌预后中的作用一直存在争议以及研究不足。本研究旨在探讨2型糖尿病对肾细胞癌患者的预后价值。 方法: 回顾性分析2013年至2018年山西医科大学第一医院行根治性或部分肾切除术治疗的451例肾细胞癌患者的临床病理资料和随访数据。评估2型糖尿病与肾细胞癌各种临床和病理参数的潜在关联。应用Kaplan-Meier法估算生存率, 应用COX回归模型进行单因素和多因素分析。 结果: 纳入研究的451例患者中, 共有74例患者(16.4%)术前患有2型糖尿病。这些患者的年龄更大, 具有更高的体质指数, 更高的高血压发病率和心血管疾病发病率, 更高的腹腔镜手术率, 以及更小的肿瘤直径(P值均<0.05)。Kaplan-Meier曲线显示2型糖尿病患者的总生存率(OS;P =0.009)、癌症特异性生存率(CSS;P =0.043)和无复发生存率(RFS;P =0.008)均低于非2型糖尿病患者。多因素分析发现, Fuhrman分级(风险比[HR] 2.542, 95%置信区间[CI] 1.115-5.795, P=0.026)和2型糖尿病(HR 3.391, CI 1.458-7.886, P=0.005)是肾细胞癌患者术后总生存率的独立危险因素, 2型糖尿病是肾细胞癌患者术后癌症特异性生存率(HR 4.637, 95% CI 1.420-15.139, P=0.011)和无复发生存率(HR 3.492, 95% CI 1.516- 8.044, P=0.003)的独立危险因素。 结论: 与非2型糖尿病患者相比, 合并2型糖尿病的肾细胞癌患者总生存期更短, 肾癌死亡风险更高, 复发风险增加。.
journal_name
J Diabetesjournal_title
Journal of diabetesauthors
Yang H,Yin K,Wang Y,Xia M,Zhang R,Wang W,Chen J,Wang C,Shuang Wdoi
10.1111/1753-0407.12957subject
Has Abstractpub_date
2019-12-01 00:00:00pages
993-1001issue
12eissn
1753-0393issn
1753-0407journal_volume
11pub_type
杂志文章abstract:BACKGROUND:The higher probability of type 2 diabetes mellitus (T2DM) in the Uygur population is due to a greater waist: hip ratio and visceral fat. This study investigated DNA methylation of tumor necrosis factor-α (TNF), monocyte chemoattractant protein-1 (MCP1), and adiponectin (ADIPOQ) in visceral adipose tissue in...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12478
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic β-cells are destroyed by infiltrating immune cells. Bilateral cooperation of pancreatic β-cells and immune cells has been proposed in the progression of T1D, but as yet no systems study has investigated this possibility. The aims of the study...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12483
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Obesity and shorter telomeres increase the risk for diabetes complications and mortality. However, the relationship between obesity and telomere length in diverse Asian populations with type 2 diabetes (T2D) is not well understood. This study examined the association of baseline and changes in obesity indice...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12864
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to assess the quality of diabetes care and characteristics of the healthcare system in underdeveloped rural mountain areas of western China. METHODS:Questionnaires were used to collect data from 288 diabetic patients with a multistage cluster sampling method in Zhongjiang Co...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12433
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to determine the prevalence and risk factors of prediabetes and diagnosed and undiagnosed diabetes mellitus (DM) in rural Bangladesh. METHODS:Using a population-based cluster random sampling strategy, 3104 adults aged ≥30 years were recruited. Fasting capillary blood glucose...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12294
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND: Diabetic peripheral neuropathy (DPN) is one of the complications of type 2 diabetes mellitus (T2DM) that decreases the quality of life of T2DM patients. Very few studies have found an association between the development and progression of DPN in T2DM and angiotensin-converting enzyme (ACE) gene insertion/d...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2012.00205.x
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Elevated blood or urinary concentrations of endocrine-disrupting chemicals (EDCs) may be related to increased risk of type 2 diabetes (T2D). The aim of the present study was to assess the role of EDCs in affecting risk of T2D and related metabolic traits. METHODS:MEDLINE was searched for cross-sectional and...
journal_title:Journal of diabetes
pub_type: 杂志文章,meta分析,评审
doi:10.1111/1753-0407.12325
更新日期:2016-07-01 00:00:00
abstract::This article reviews the known pathophysiological mechanisms of comorbid gastroesophageal reflux disease (GERD) in the diabetic patient, discusses therapeutic options in care, and provides an approach to its evaluation and management. We searched for review articles published in the past 10 years through a PubMed sear...
journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/1753-0407.12279
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Asia is experiencing a type 2 diabetes epidemic, but prevalence differs by ethnicity and level of socioeconomic development. Singapore and Mauritius have implemented comprehensive campaigns to address this public health problem. We compared diabetes and obesity prevalence trends among Chinese and South Asian...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12497
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:In addition to its glucoregulatory actions, exendin-4, a stable glucagon-like peptide-1 receptor agonist, exhibits protective effects in the pancreas and anti-obesity effects. Suitable combination treatment with other anti-obesity or pancreas protective agents would be an effective approach to optimize these...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2012.00227.x
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Currently, there is no consensus regarding the medical treatment of chronic Charcot neuroarthropathy (CN) of foot, except for effective off-loading. Because tarsal bones are predominantly trabecular, teriparatide may improve the macroarchitecture of foot bones in chronic CN. METHODS:People with diabetes and...
journal_title:Journal of diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/1753-0407.12902
更新日期:2019-09-01 00:00:00
abstract::There has been a rapid escalation of type 2 diabetes (T2D) in developing countries, with varied prevalence according to rural vs urban habitat and degree of urbanization. Some ethnic groups (eg, South Asians, other Asians, and Africans), develop diabetes a decade earlier and at a lower body mass index than Whites, hav...
journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/1753-0407.12913
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Although niacin often has beneficial effects on the lipoprotein profile, flushing is an untoward effect associated with its use. Aspirin can only reduce the flushing response by 30-40%. Thus, the aim of the present study was to investigate the mechanisms of niacin-induced flushing, with and without aspirin, ...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2012.00216.x
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:There is a wide variety of dressings currently available for the treatment of diabetic foot ulcers (DFUs). Because of a lack of evidence from head-to-head randomized controlled trials (RCTs), the relative effects of these dressings in DFU patients remain unclear. This study compared the efficacy of nine dres...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12871
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:To evaluate the association between thyroid autoimmunity and psychiatric disorders (depression, anxiety, eating disorder, schizophrenia or attention-deficit/hyperactivity disorder) among adolescents and young adults with type 1 diabetes (11-25 years). METHODS:We compared 9368 type 1 diabetes patients with t...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.13145
更新日期:2020-12-16 00:00:00
abstract:BACKGROUND:Liver X receptors (LXRs) including LXRα and LXRβ are members of the nuclear hormone receptor superfamily of ligand activated transcription factors, which serve as lipid sensors to regulate expression of genes controlling many aspects of cholesterol and fatty acid metabolism. The liver is the central organ in...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12081
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Supervised treadmill exercise is the recommended therapy for peripheral arterial disease (PAD) patients with intermittent claudication (IC). However, most PAD patients do not exhibit typical symptoms of IC. The aim of the present study was to explore the efficacy and safety of intensive walking exercise in P...
journal_title:Journal of diabetes
pub_type: 杂志文章,meta分析,评审
doi:10.1111/1753-0407.12304
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the effect of a new self-care guide package on gestational diabetes mellitus (GDM). METHODS:This randomized clinical trial was conducted on 152 women with GDM. The intervention group was provided with the self-care guide package and three face-to-face educational sessi...
journal_title:Journal of diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/1753-0407.12827
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:An increase in the prevalence of type 2 diabetes mellitus occurs in immigrants from developing regions to Western countries. However, the dynamics of these transitions in relation to the duration of residence in the new environment are not clearly defined. METHODS:Data concerning cardiovascular risk factors...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12215
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Glucagon-like peptide-1 (GLP-1) and its stable analogue exendin-4 maintain glucose homeostasis by modulating insulin secretion from pancreatic β-cells and controlling hepatic glucose output. Glucokinase (GK), by catalysing the first step in glycolysis, plays an important role in glucose-stimulated insulin se...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2012.00193.x
更新日期:2012-12-01 00:00:00
abstract::Skin autofluorescence is increased in diabetes, rises with age, and predicts diabetes-related complications. Exposure to secondhand smoke, because one or more family members are smokers, further increases skin autofluorescence in children and young adults with type 1 diabetes. Elimination of passive smoking should be ...
journal_title:Journal of diabetes
pub_type: 信件
doi:10.1111/1753-0407.12498
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to develop a simple nomogram that can be used to predict the risk of diabetes mellitus (DM) in the asymptomatic non-diabetic subjects based on non-laboratory- and laboratory-based risk algorithms. METHODS:Anthropometric data, plasma fasting glucose, full lipid profile, exerc...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12310
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Few studies have focused on postprandial incretin responses to different carbohydrate meals. Therefore, we designed a study to compare the different effects of two carbohydrates (75 g oral glucose, a monosaccharide and 100 g standard noodle, a polysaccharide, with 75 g carbohydrates equivalently) on postpran...
journal_title:Journal of diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/1753-0407.12245
更新日期:2015-11-01 00:00:00
abstract::Following on from impressive economic development and urbanization, China is currently experiencing a high prevalence of metabolic syndrome. Patients with metabolic syndrome suffer from the "The Deadly Quartet" of hyperglycemia, hypertriglyceridemia, hypertension, and central (or upper body) obesity. Current treatment...
journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/j.1753-0407.2010.00090.x
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:The association between dental caries and metabolic syndrome (MetS) is inconsistent. The aim of the present study was to assess the relationship between dental caries and MetS and its components in a middle-aged Chinese population. METHODS:A cross-sectional analysis was performed of 13 998 participants aged...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12424
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Uncontrolled diabetes mellitus causes neuronal damage because of increased intracellular glucose. Natural products as complementary therapy may reduce neuronal complications. This study investigated whether fish oil (FO) and wheat germ oil (WGO) supplementation protects the brain in streptozotocin (STZ)-indu...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12518
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Although diabetes is associated with ethnicity and worse cardiac surgery outcomes, no research has been done to study the effect of both diabetes and ethnicity on cardiac surgery outcomes in a multiethnic Southeast Asian cohort. Hence, this study aimed to delineate the association of ethnicity on outcomes af...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12961
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:It is clear that aerobic training (AT) can delay pancreatic exhaustion and slow the progression from prediabetes to type 2 diabetes (T2D), but there is little information regarding the effects of resistance training (RT) in people with prediabetes. This study compared the effectiveness of RT and AT in improv...
journal_title:Journal of diabetes
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/1753-0407.12955
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:There is little information on medication use, trends across time, and the impact of guidelines on appropriate use of antidiabetic drugs in participants with type 2 diabetes mellitus (T2DM) with chronic kidney disease (CKD). METHODS:A cross-sectional analysis of the National Health and Nutrition Examination...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.13003
更新日期:2020-05-01 00:00:00
abstract::The 2011 United Nations political declaration against non-communicable diseases (NCDs) targeted four major risk factors: tobacco use, harmful use of alcohol, an unhealthy diet, and a lack of physical activity. The Framework Convention on Tobacco Control (FCTC), MPOWER strategies, and the four-stage model of the tobacc...
journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/1753-0407.12647
更新日期:2018-07-01 00:00:00