Intensive walking exercise for lower extremity peripheral arterial disease: A systematic review and meta-analysis.

Abstract:

BACKGROUND:Supervised treadmill exercise is the recommended therapy for peripheral arterial disease (PAD) patients with intermittent claudication (IC). However, most PAD patients do not exhibit typical symptoms of IC. The aim of the present study was to explore the efficacy and safety of intensive walking exercise in PAD patients with and without IC. METHODS:The PubMed, Embase and Cochrane Library databases were systematically searched. Randomized controlled trials comparing the effects of intensive walking exercise with usual care in patients with PAD were included for systematic review and meta-analysis. RESULTS:Eighteen trials with 1200 patients were eligible for the present analysis. Compared with usual care, intensive walking exercise significantly improved the maximal walking distance (MWD), pain-free walking distance, and the 6-min walking distance in patients with PAD (P < 0.00001 for all). Subgroup analyses indicated that a lesser improvement in MWD was observed in the subgroup with more diabetes patients, and that the subgroup with better baseline walking ability exhibited greater improvement in walking performance. In addition, similar improvements in walking performance were observed for exercise programs of different durations and modalities. No significant difference was found in adverse events between the intensive walking and usual care groups (relative risk 0.84; 95% confidence interval 0.51, 1.39; P = 0.50). CONCLUSIONS:Regardless of exercise length and modality, regularly intensive walking exercise improves walking ability in PAD patients more than usual care. The presence of diabetes may attenuate the improvements in walking performance in patients with PAD following exercise.

journal_name

J Diabetes

journal_title

Journal of diabetes

authors

Lyu X,Li S,Peng S,Cai H,Liu G,Ran X

doi

10.1111/1753-0407.12304

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

363-77

issue

3

eissn

1753-0393

issn

1753-0407

journal_volume

8

pub_type

杂志文章,meta分析,评审
  • Efficacy of acarbose and metformin in newly diagnosed type 2 diabetes patients stratified by HbA1c levels.

    abstract:BACKGROUND:The aim of the present study was to investigate whether the therapeutic efficacy of acarbose and metformin is correlated with baseline HbA1c levels in Chinese patients with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS:Data for 711 subjects were retrieved from the MARCH (Metformin and AcaRbose in...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/1753-0407.12337

    authors: Zhang JP,Wang N,Xing XY,Yang ZJ,Wang X,Yang WY

    更新日期:2016-07-01 00:00:00

  • Elucidation of the novel role of ethnicity and diabetes in poorer outcomes after cardiac surgery in a multiethnic Southeast Asian cohort.

    abstract:BACKGROUND:Although diabetes is associated with ethnicity and worse cardiac surgery outcomes, no research has been done to study the effect of both diabetes and ethnicity on cardiac surgery outcomes in a multiethnic Southeast Asian cohort. Hence, this study aimed to delineate the association of ethnicity on outcomes af...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/1753-0407.12961

    authors: Moorthy V,Liu W,Chan SP,Chew STH,Ti LK

    更新日期:2020-01-01 00:00:00

  • Combining glomerular basement membrane and tubular basement membrane assessment improves the prediction of diabetic end-stage renal disease.

    abstract:BACKGROUND:To address the prognostic value of combining tubular basement membrane (TBM) and glomerular basement membrane (GBM) thickness in diabetic nephropathy (DN). METHODS:This retrospective study enrolled 110 patients with type 2 diabetes and biopsy-proven DN from 2011 to 2018. The pathological findings were confi...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/1753-0407.13150

    authors: Zhao L,Zhang J,Lei S,Ren H,Zou Y,Bai L,Zhang R,Xu H,Li L,Zhao Y,Cooper ME,Tong N,Zhang J,Liu F

    更新日期:2020-12-22 00:00:00

  • Ethnic disparities in relationships of obesity indices with telomere length in Asians with type 2 diabetes.

    abstract:BACKGROUND:Obesity and shorter telomeres increase the risk for diabetes complications and mortality. However, the relationship between obesity and telomere length in diverse Asian populations with type 2 diabetes (T2D) is not well understood. This study examined the association of baseline and changes in obesity indice...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/1753-0407.12864

    authors: Gurung RL,M Y,Liu S,Liu JJ,Chan SM,Moh MC,Ang K,Tang WE,Sum CF,Tavintharan S,Lim SC,SMART2D Study.

    更新日期:2019-05-01 00:00:00

  • Extracellular signal-regulated kinase-5: Novel mediator of insulin and tumor necrosis factor α-stimulated vascular cell adhesion molecule-1 expression in vascular cells.

    abstract:BACKGROUND:Atherosclerosis may be stimulated by the increased presence of insulin and tumor necrosis-factor-α (TNFα) with subsequent expression of vascular cell adhesion molecule-1 (VCAM-1). We hypothesized that extracellular signal-regulated kinase-5 (ERK5) plays an important role in insulin and TNFα-stimulated total ...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/1753-0407.12132

    authors: Mackesy DZ,Goalstone ML

    更新日期:2014-11-01 00:00:00

  • Gestational diabetes mellitus and risk of incident primary cancer: A population-based retrospective cohort study.

    abstract::Highlights A large retrospective study indicates no association between GDM and most types of cancer; this is in contrast to a few smaller studies that have suggested an association with cancer. An increased risk of thyroid cancer in mothers with GDM was demonstrated. While this risk requires further investigation, it...

    journal_title:Journal of diabetes

    pub_type: 信件

    doi:10.1111/1753-0407.12988

    authors: Pace R,Rahme E,Dasgupta K

    更新日期:2020-01-01 00:00:00

  • Metabolic Syndrome and clinical outcomes in patients infected with COVID-19: Does age, sex and race of the patient with Metabolic Syndrome matter?

    abstract:BACKGROUND:Metabolic syndrome (MetS) is highly prevalent worldwide, and its individual components obesity, diabetes, and hypertension have been identified as risk factors to develop severe coronavirus disease 2019 (COVID-19); however, data on MetS and clinical outcomes in COVID-19 are scarce. This study aims to determi...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/1753-0407.13157

    authors: Lohia P,Kapur S,Benjaram S,Pandey A,Mir T,Seyoum B

    更新日期:2021-01-16 00:00:00

  • Glucose excursions and hypoglycemia in patients with type 2 diabetes treated with mitiglinide/voglibose versus glimepiride: A randomized cross-over trial.

    abstract:BACKGROUND:Glucose excursions and hypoglycemia are associated with cardiovascular complications. However, no studies have evaluated glucose excursions and the frequency of hypoglycemia in patients treated with mitiglinide/voglibose versus glimepiride as add-on to dipeptidyl peptidase-4 inhibitor therapy. METHODS:This ...

    journal_title:Journal of diabetes

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/1753-0407.12658

    authors: Fujimoto K,Shibayama Y,Yamaguchi E,Honjo S,Hamasaki A,Hamamoto Y

    更新日期:2018-08-01 00:00:00

  • Teriparatide (recombinant human parathyroid hormone [1-34]) increases foot bone remodeling in diabetic chronic Charcot neuroarthropathy: a randomized double-blind placebo-controlled study.

    abstract:BACKGROUND:Currently, there is no consensus regarding the medical treatment of chronic Charcot neuroarthropathy (CN) of foot, except for effective off-loading. Because tarsal bones are predominantly trabecular, teriparatide may improve the macroarchitecture of foot bones in chronic CN. METHODS:People with diabetes and...

    journal_title:Journal of diabetes

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/1753-0407.12902

    authors: Rastogi A,Hajela A,Prakash M,Khandelwal N,Kumar R,Bhattacharya A,Mittal BR,Bhansali A,Armstrong DG

    更新日期:2019-09-01 00:00:00

  • Association of characteristics of people with type 2 diabetes mellitus with discordant values of fasting glucose and HbA1c.

    abstract:BACKGROUND:Primary care physicians frequently encounter people with type 2 diabetes mellitus (T2DM) with discordant values for fasting glucose and HbA1c. The aim of this study was to identify the prevalence and characteristics of people in whom blood glucose and HbA1c did not match. METHODS:Overall, 64 553 people with...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/1753-0407.12823

    authors: Rathmann W,Bongaerts B,Kostev K

    更新日期:2018-12-01 00:00:00

  • Diabetes in developing countries.

    abstract::There has been a rapid escalation of type 2 diabetes (T2D) in developing countries, with varied prevalence according to rural vs urban habitat and degree of urbanization. Some ethnic groups (eg, South Asians, other Asians, and Africans), develop diabetes a decade earlier and at a lower body mass index than Whites, hav...

    journal_title:Journal of diabetes

    pub_type: 杂志文章,评审

    doi:10.1111/1753-0407.12913

    authors: Misra A,Gopalan H,Jayawardena R,Hills AP,Soares M,Reza-Albarrán AA,Ramaiya KL

    更新日期:2019-07-01 00:00:00

  • Randomized clinical trial of standard dietary treatment versus a low-carbohydrate/high-protein diet or the LighterLife Programme in the management of obesity*.

    abstract:BACKGROUND:With the current obesity epidemic, the search for effective weight loss approaches is required. In the present study, changes in weight, body composition and cardiovascular (CV) risk in response to a low-fat, reduced-energy diet (LFRE), a low-carbohydrate/high-protein diet (LCHP), or a commercially available...

    journal_title:Journal of diabetes

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1753-0407.2009.00033.x

    authors: Rolland C,Hession M,Murray S,Wise A,Broom I

    更新日期:2009-09-01 00:00:00

  • Fish oil and wheat germ oil supplementation modulates brain injury in streptozotocin-induced diabetic rats.

    abstract:BACKGROUND:Uncontrolled diabetes mellitus causes neuronal damage because of increased intracellular glucose. Natural products as complementary therapy may reduce neuronal complications. This study investigated whether fish oil (FO) and wheat germ oil (WGO) supplementation protects the brain in streptozotocin (STZ)-indu...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/1753-0407.12518

    authors: Khedr NF

    更新日期:2017-11-01 00:00:00

  • Prediabetes, diagnosed and undiagnosed diabetes, their risk factors and association with knowledge of diabetes in rural Bangladesh: The Bangladesh Population-based Diabetes and Eye Study.

    abstract:BACKGROUND:The aim of the present study was to determine the prevalence and risk factors of prediabetes and diagnosed and undiagnosed diabetes mellitus (DM) in rural Bangladesh. METHODS:Using a population-based cluster random sampling strategy, 3104 adults aged ≥30 years were recruited. Fasting capillary blood glucose...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/1753-0407.12294

    authors: Islam FM,Chakrabarti R,Islam MT,Wahab M,Lamoureux E,Finger RP,Shaw JE

    更新日期:2016-03-01 00:00:00

  • Synergistic effects of depression and obesity on type 2 diabetes incidence in Chinese adults.

    abstract:BACKGROUND:Cross-sectional studies have supported the association among depression, obesity, and type 2 diabetes, but the causality remains controversial in Chinese adults. In this longitudinal study, we evaluated the synergistic effect of depression and obesity on the risk of type 2 diabetes. METHODS:This study inclu...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/1753-0407.12968

    authors: Ning F,Zhang D,Xue B,Zhang L,Zhang J,Zhu Z,Zhang D,Gao R,Pang Z,Qiao Q,Qingdao Diabetes Prevention Program.

    更新日期:2020-02-01 00:00:00

  • Can we go beyond surrogates?

    abstract::Two years ago, data presented at the annual American Diabetes Association (ADA) meeting in New Orleans showed a marked decrease in deaths, especially those due to cardiovascular disease, with the use of empagliflozin. Two major questions have been asked: (i) was the result a fluke; and (ii) was it a class effect, or w...

    journal_title:Journal of diabetes

    pub_type: 社论

    doi:10.1111/1753-0407.12583

    authors: Drexler A

    更新日期:2017-11-01 00:00:00

  • Glucagon-like peptide 1-potentiated insulin secretion and proliferation of pancreatic β-cells.

    abstract::Glucagon-like peptide-1 (GLP-1) is the primary incretin hormone secreted from the intestine upon uptake of food to stimulate insulin secretion from pancreatic β-cells. GLP-1 exerts its effects by binding to its G-protein coupled receptors and subsequently activating adenylate cyclase, leading to generation of cyclic a...

    journal_title:Journal of diabetes

    pub_type: 杂志文章,评审

    doi:10.1111/1753-0407.12161

    authors: Ma X,Guan Y,Hua X

    更新日期:2014-09-01 00:00:00

  • Urinary α1 -microglobulin and albumin excretion in children and adolescents with type 1 diabetes.

    abstract:BACKGROUND:The present study investigated the correlation between urinary α1 -microglobulin as a marker of tubular dysfunction and albumin excretion in children and adolescents with type 1 diabetes (T1D). METHODS:Ninety-two Egyptian patients with T1D were included in the study (mean [± SD] age 14.14 ± 5.13 years). The...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/1753-0407.12383

    authors: Saif A,Soliman N

    更新日期:2017-01-01 00:00:00

  • Circulating dipeptidyl peptidase-4 activity correlates with measures of hepatocyte apoptosis and fibrosis in non-alcoholic fatty liver disease in type 2 diabetes mellitus and obesity: A dual cohort cross-sectional study.

    abstract:BACKGROUND:Intrahepatic expression of dipeptidyl peptidase-4 (DPP4), and circulating DPP4 (cDPP4) levels and its enzymatic activity, are increased in non-alcoholic fatty liver disease (NAFLD) and in type 2 diabetes mellitus and/or obesity. DPP4 has been implicated as a causative factor in NAFLD progression but few stud...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/1753-0407.12237

    authors: Williams KH,Vieira De Ribeiro AJ,Prakoso E,Veillard AS,Shackel NA,Brooks B,Bu Y,Cavanagh E,Raleigh J,McLennan SV,McCaughan GW,Keane FM,Zekry A,Gorrell MD,Twigg SM

    更新日期:2015-11-01 00:00:00

  • Effect of a new self-care guide package on maternal and neonatal outcomes in gestational diabetes: A randomized control trial.

    abstract:BACKGROUND:The aim of this study was to determine the effect of a new self-care guide package on gestational diabetes mellitus (GDM). METHODS:This randomized clinical trial was conducted on 152 women with GDM. The intervention group was provided with the self-care guide package and three face-to-face educational sessi...

    journal_title:Journal of diabetes

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/1753-0407.12827

    authors: Kolivand M,Rahimi MA,Keramat A,Shariati M,Emamian MH

    更新日期:2019-02-01 00:00:00

  • Review of gastroesophageal reflux disease (GERD) in the diabetic patient.

    abstract::This article reviews the known pathophysiological mechanisms of comorbid gastroesophageal reflux disease (GERD) in the diabetic patient, discusses therapeutic options in care, and provides an approach to its evaluation and management. We searched for review articles published in the past 10 years through a PubMed sear...

    journal_title:Journal of diabetes

    pub_type: 杂志文章,评审

    doi:10.1111/1753-0407.12279

    authors: Punjabi P,Hira A,Prasad S,Wang X,Chokhavatia S

    更新日期:2015-09-01 00:00:00

  • G protein-coupled receptor kinase-2: A potential biomarker for early diabetic cardiomyopathy.

    abstract:BACKGROUND:G protein-coupled receptor kinase-2 (GRK2) has been shown as a key regulator of cardiac function, and the myocardial GRK2 levels are mirrored by the levels in peripheral blood mononuclear cells (PBMCs). In this study, we evaluated the myocardial and PBMCs GRK2 levels in early diabetic cardiomyopathy (DCM). ...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/1753-0407.12991

    authors: Lai S,Fu X,Yang S,Zhang S,Lin Q,Zhang M,Chen H

    更新日期:2020-03-01 00:00:00

  • Postprandial glucose, insulin and incretin responses to different carbohydrate tolerance tests.

    abstract:BACKGROUND:Few studies have focused on postprandial incretin responses to different carbohydrate meals. Therefore, we designed a study to compare the different effects of two carbohydrates (75 g oral glucose, a monosaccharide and 100 g standard noodle, a polysaccharide, with 75 g carbohydrates equivalently) on postpran...

    journal_title:Journal of diabetes

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/1753-0407.12245

    authors: Deng Y,Zhang Y,Zheng S,Hong J,Wang C,Liu T,Sun Z,Gu W,Gu Y,Shi J,Yao S,Wang W,Ning G

    更新日期:2015-11-01 00:00:00

  • Role of prostaglandin D2 and the autonomic nervous system in niacin-induced flushing.

    abstract:BACKGROUND:Although niacin often has beneficial effects on the lipoprotein profile, flushing is an untoward effect associated with its use. Aspirin can only reduce the flushing response by 30-40%. Thus, the aim of the present study was to investigate the mechanisms of niacin-induced flushing, with and without aspirin, ...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1753-0407.2012.00216.x

    authors: Parson HK,Harati H,Cooper D,Vinik AI

    更新日期:2013-03-01 00:00:00

  • Assessment of diabetes care and the healthcare system in economically and transport underdeveloped rural mountain areas of western China: A cross-sectional survey.

    abstract:BACKGROUND:The aim of the present study was to assess the quality of diabetes care and characteristics of the healthcare system in underdeveloped rural mountain areas of western China. METHODS:Questionnaires were used to collect data from 288 diabetic patients with a multistage cluster sampling method in Zhongjiang Co...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/1753-0407.12433

    authors: Ke L,Zhang Y,Wang X,Li S,Yang W,Tong N

    更新日期:2017-05-01 00:00:00

  • Are psychiatric disorders associated with thyroid hormone therapy in adolescents and young adults with type 1 diabetes?

    abstract:BACKGROUND:To evaluate the association between thyroid autoimmunity and psychiatric disorders (depression, anxiety, eating disorder, schizophrenia or attention-deficit/hyperactivity disorder) among adolescents and young adults with type 1 diabetes (11-25 years). METHODS:We compared 9368 type 1 diabetes patients with t...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/1753-0407.13145

    authors: Eckert A,Galler A,Papsch M,Hess M,Holder M,Döing C,Bierkamp-Christophersen D,Hammer E,Pappa A,Lanzinger S

    更新日期:2020-12-16 00:00:00

  • Comparing the effects of 6 months aerobic exercise and resistance training on metabolic control and β-cell function in Chinese patients with prediabetes: A multicenter randomized controlled trial.

    abstract:BACKGROUND:It is clear that aerobic training (AT) can delay pancreatic exhaustion and slow the progression from prediabetes to type 2 diabetes (T2D), but there is little information regarding the effects of resistance training (RT) in people with prediabetes. This study compared the effectiveness of RT and AT in improv...

    journal_title:Journal of diabetes

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/1753-0407.12955

    authors: Yuan X,Dai X,Liu L,Hsue C,Miller JD,Fang Z,Li J,Feng J,Huang Y,Liu C,Shen J,Chen T,Liu Y,Mordes J,Lou Q

    更新日期:2020-01-01 00:00:00

  • Serum concentrations of vitamin D and parathyroid hormone and prevalent metabolic syndrome among adults in the United States.

    abstract:BACKGROUND:Some reports suggest that concentrations of vitamin D are inversely, whereas concentrations of parathyroid hormone (PTH) are directly, associated with prevalent metabolic syndrome. Because of lingering uncertainty about these associations, we examined the cross-sectional associations between serum concentrat...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1753-0407.2009.00046.x

    authors: Ford ES,Zhao G,Li C,Pearson WS

    更新日期:2009-12-01 00:00:00

  • Performance of non-traditional hyperglycemia biomarkers by chronic kidney disease status in older adults with diabetes: Results from the Atherosclerosis Risk in Communities Study.

    abstract:BACKGROUND:In people with chronic kidney disease (CKD), HbA1c may be a problematic measure of glycemic control. Glycated albumin and fructosamine have been proposed as better markers of hyperglycemia in CKD. In the present study we investigated associations of HbA1c, glycated albumin, and fructosamine with fasting gluc...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/1753-0407.12618

    authors: Jung M,Warren B,Grams M,Kwong YD,Shafi T,Coresh J,Rebholz CM,Selvin E

    更新日期:2018-04-01 00:00:00

  • Effect of hydroxypropyl methylcellulose on obesity and glucose metabolism in a diet-induced obesity mouse model.

    abstract:BACKGROUND:To investigate the effect of hydroxypropyl methylcellulose (HPMC) on weight loss and metabolic disorders associated with obesity using a high-fat diet-induced obese mouse model under a high-fat diet regimen. METHODS: Obese male C57BL/6J (B6) mice were fed either a high-fat (60% kcal), low-fat (10% kcal), or...

    journal_title:Journal of diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1753-0407.2011.00118.x

    authors: Hung SC,Anderson WH,Albers DR,Langhorst ML,Young SA

    更新日期:2011-06-01 00:00:00