Abstract:
BACKGROUND:Although diabetes is associated with ethnicity and worse cardiac surgery outcomes, no research has been done to study the effect of both diabetes and ethnicity on cardiac surgery outcomes in a multiethnic Southeast Asian cohort. Hence, this study aimed to delineate the association of ethnicity on outcomes after cardiac surgery among diabetics in a multiethnic Southeast Asian population. METHODS:Perioperative data from 3008 adult patients undergoing elective cardiac surgery from 2008 to 2011 at the two main heart centers in Singapore was analyzed prospectively, and confirmatory analysis was conducted with the generalized structural equation model. RESULTS:Diabetes was significantly associated with postoperative acute kidney injury (AKI) and postoperative hyperglycemia. Postoperative AKI, Malay ethnicity, and blood transfusion were associated with postoperative dialysis. Postoperative AKI and blood transfusion were also associated with postoperative arrhythmias. In turn, postoperative dialysis and arrhythmias increased the odds of 30-day mortality by 7.7- and 18-fold, respectively. CONCLUSIONS:This study identified that diabetes is directly associated with postoperative hyperglycemia and AKI, and indirectly associated with arrhythmias and 30-day mortality. Further, we showed that ethnicity not only affects the prevalence of diabetes, but also postoperative diabetes-related outcomes. :背景: 尽管糖尿病与种族及心脏手术后不良结局有关, 但是目前还没有研究调查在多种族的东南亚人群中, 糖尿病与种族对心脏手术结局的影响。因此, 本研究旨在阐明在多种族的东南亚人群中, 种族与糖尿病患者心脏手术后结局的相关性。 方法: 对2008年至2011年间在新加坡两个主要心脏中心接受择期心脏手术的3008例成年患者的围手术期资料进行前瞻性分析, 并用广义结构方程模型进行验证性分析。 结果: 糖尿病与术后急性肾损伤(acute kidney injury, AKI)及术后高血糖显著相关。术后AKI、马来族以及输血均与术后透析相关。术后AKI和输血还与术后心律失常相关。随之而来, 术后透析和心律失常导致30天死亡率分别增加了7.7倍与18倍。 结论: 本研究发现糖尿病与术后高血糖及AKI直接相关, 与心律失常和30天死亡率间接相关。此外, 我们发现种族不仅影响糖尿病的患病率, 也影响术后糖尿病相关的结局。.
journal_name
J Diabetesjournal_title
Journal of diabetesauthors
Moorthy V,Liu W,Chan SP,Chew STH,Ti LKdoi
10.1111/1753-0407.12961subject
Has Abstractpub_date
2020-01-01 00:00:00pages
58-65issue
1eissn
1753-0393issn
1753-0407journal_volume
12pub_type
杂志文章abstract:BACKGROUND:The aim of the present study was to develop a simple nomogram that can be used to predict the risk of diabetes mellitus (DM) in the asymptomatic non-diabetic subjects based on non-laboratory- and laboratory-based risk algorithms. METHODS:Anthropometric data, plasma fasting glucose, full lipid profile, exerc...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12310
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:To investigate the effect of hydroxypropyl methylcellulose (HPMC) on weight loss and metabolic disorders associated with obesity using a high-fat diet-induced obese mouse model under a high-fat diet regimen. METHODS: Obese male C57BL/6J (B6) mice were fed either a high-fat (60% kcal), low-fat (10% kcal), or...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2011.00118.x
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:In people with chronic kidney disease (CKD), HbA1c may be a problematic measure of glycemic control. Glycated albumin and fructosamine have been proposed as better markers of hyperglycemia in CKD. In the present study we investigated associations of HbA1c, glycated albumin, and fructosamine with fasting gluc...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12618
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome (MetS) is highly prevalent worldwide, and its individual components obesity, diabetes, and hypertension have been identified as risk factors to develop severe coronavirus disease 2019 (COVID-19); however, data on MetS and clinical outcomes in COVID-19 are scarce. This study aims to determi...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.13157
更新日期:2021-01-16 00:00:00
abstract:BACKGROUND:Convincing evidence indicates that the consumption of inulin-type fructans, inulin, and oligofructose has beneficial effects on blood glucose changes in animal models, although data in humans have been considered equivocal. As such, a systematic review of available literature on humans was conducted to evalu...
journal_title:Journal of diabetes
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1753-0407.2010.00099.x
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:The present study investigated the correlation between urinary α1 -microglobulin as a marker of tubular dysfunction and albumin excretion in children and adolescents with type 1 diabetes (T1D). METHODS:Ninety-two Egyptian patients with T1D were included in the study (mean [± SD] age 14.14 ± 5.13 years). The...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12383
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The relationship among components of metabolic syndrome (MetS) and their association with diabetes is unclear in West Asia. The aim of the present study was to conduct factor analysis of MetS components and the effect these factors have on the incidence of type 2 diabetes (T2D) in a population-based cohort s...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12252
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Glucagon-like peptide-1 (GLP-1) analogues have emerged as insulin secretagogues and are widely used in type 2 diabetic patients. GLP-1 analogues also demonstrate a promotion of beta cell proliferation and reduction of apoptosis in rodents. In the present study, we investigated the protection of pancreatic be...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12061
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:With the current obesity epidemic, the search for effective weight loss approaches is required. In the present study, changes in weight, body composition and cardiovascular (CV) risk in response to a low-fat, reduced-energy diet (LFRE), a low-carbohydrate/high-protein diet (LCHP), or a commercially available...
journal_title:Journal of diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1753-0407.2009.00033.x
更新日期:2009-09-01 00:00:00
abstract::Highlights A large retrospective study indicates no association between GDM and most types of cancer; this is in contrast to a few smaller studies that have suggested an association with cancer. An increased risk of thyroid cancer in mothers with GDM was demonstrated. While this risk requires further investigation, it...
journal_title:Journal of diabetes
pub_type: 信件
doi:10.1111/1753-0407.12988
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Uncontrolled diabetes mellitus causes neuronal damage because of increased intracellular glucose. Natural products as complementary therapy may reduce neuronal complications. This study investigated whether fish oil (FO) and wheat germ oil (WGO) supplementation protects the brain in streptozotocin (STZ)-indu...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12518
更新日期:2017-11-01 00:00:00
abstract::Islet transplantation is an attractive concept for the treatment of Type 1 diabetes because of its potential high efficacy and minimal invasion to patients. The treatment may effectively control blood glucose for brittle Type 1 diabetes, resulting in a marked reduction in hypoglycemic episodes and improvements in HbA1...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2009.00048.x
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:The higher probability of type 2 diabetes mellitus (T2DM) in the Uygur population is due to a greater waist: hip ratio and visceral fat. This study investigated DNA methylation of tumor necrosis factor-α (TNF), monocyte chemoattractant protein-1 (MCP1), and adiponectin (ADIPOQ) in visceral adipose tissue in...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12478
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to investigate whether the therapeutic efficacy of acarbose and metformin is correlated with baseline HbA1c levels in Chinese patients with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS:Data for 711 subjects were retrieved from the MARCH (Metformin and AcaRbose in...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12337
更新日期:2016-07-01 00:00:00
abstract::Diabetes mellitus is a metabolic disease with a considerable impact on healthcare owing to its increased prevalence and high mortality rate. Structural, morphological, and physiological changes in each of the ocular components have been described in detail. Autofluorescence has been described as a good indicator of me...
journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/1753-0407.12423
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Limited information exists regarding the efficacy of pregabalin in Chinese patients with painful diabetic peripheral neuropathy (pDPN). METHODS:An 11-week double-blind placebo-controlled trial was performed in Chinese pDPN patients randomized (1 : 1) to 300 mg/day pregabalin or placebo. The primary outcome ...
journal_title:Journal of diabetes
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/1753-0407.12585
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Glucagon-like peptide-1 (GLP-1) and its stable analogue exendin-4 maintain glucose homeostasis by modulating insulin secretion from pancreatic β-cells and controlling hepatic glucose output. Glucokinase (GK), by catalysing the first step in glycolysis, plays an important role in glucose-stimulated insulin se...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2012.00193.x
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Considerable uncertainty remains about obstructive lung function( OLF) in adults with metabolic syndrome (MetS). The aim of the present study was to examine pulmonary function status in adults with and without MetS. METHODS:We used data from 3109 participants aged ≥20 years of the National Health and Nutrit...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12136
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Currently, there is no consensus regarding the medical treatment of chronic Charcot neuroarthropathy (CN) of foot, except for effective off-loading. Because tarsal bones are predominantly trabecular, teriparatide may improve the macroarchitecture of foot bones in chronic CN. METHODS:People with diabetes and...
journal_title:Journal of diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/1753-0407.12902
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:An increase in the prevalence of type 2 diabetes mellitus occurs in immigrants from developing regions to Western countries. However, the dynamics of these transitions in relation to the duration of residence in the new environment are not clearly defined. METHODS:Data concerning cardiovascular risk factors...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12215
更新日期:2015-07-01 00:00:00
abstract::There has been a rapid escalation of type 2 diabetes (T2D) in developing countries, with varied prevalence according to rural vs urban habitat and degree of urbanization. Some ethnic groups (eg, South Asians, other Asians, and Africans), develop diabetes a decade earlier and at a lower body mass index than Whites, hav...
journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/1753-0407.12913
更新日期:2019-07-01 00:00:00
abstract::Adenosine triphosphate (ATP) synthesis and release in mitochondria play critical roles in regulating insulin secretion in pancreatic β cells. Mitochondrial dysfunction is mainly characterized by a decrease in ATP production, which is a central event in the progression of pancreatic β cell dysfunction and diabetes. ATP...
journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/1753-0407.12098
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:The effect of postload glucose spikes (PGS), the difference between 2 hour post-load plasma glucose (2hPLPG) and fasting plasma glucose (FPG), on post-myocardial infarction (post-MI) prognosis in nondiabetic patients is unexplored. METHODS:This is a retrospective cohort analysis of 847 nondiabetic post-MI s...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.13111
更新日期:2021-03-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to determine the prevalence and risk factors of prediabetes and diagnosed and undiagnosed diabetes mellitus (DM) in rural Bangladesh. METHODS:Using a population-based cluster random sampling strategy, 3104 adults aged ≥30 years were recruited. Fasting capillary blood glucose...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12294
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Glucose excursions and hypoglycemia are associated with cardiovascular complications. However, no studies have evaluated glucose excursions and the frequency of hypoglycemia in patients treated with mitiglinide/voglibose versus glimepiride as add-on to dipeptidyl peptidase-4 inhibitor therapy. METHODS:This ...
journal_title:Journal of diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/1753-0407.12658
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Women with previous gestational diabetes mellitus (pGDM) are at increased risk of developing type 2 diabetes later in life. The aim of this study was to determine if circulating levels of metabolic hormones 12 weeks following a GDM pregnancy are associated with an increased risk of type 2 diabetes 8-10 years...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12209
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Liver X receptors (LXRs) including LXRα and LXRβ are members of the nuclear hormone receptor superfamily of ligand activated transcription factors, which serve as lipid sensors to regulate expression of genes controlling many aspects of cholesterol and fatty acid metabolism. The liver is the central organ in...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12081
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to assess the quality of diabetes care and characteristics of the healthcare system in underdeveloped rural mountain areas of western China. METHODS:Questionnaires were used to collect data from 288 diabetic patients with a multistage cluster sampling method in Zhongjiang Co...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12433
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Asia is experiencing a type 2 diabetes epidemic, but prevalence differs by ethnicity and level of socioeconomic development. Singapore and Mauritius have implemented comprehensive campaigns to address this public health problem. We compared diabetes and obesity prevalence trends among Chinese and South Asian...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12497
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Primary care physicians frequently encounter people with type 2 diabetes mellitus (T2DM) with discordant values for fasting glucose and HbA1c. The aim of this study was to identify the prevalence and characteristics of people in whom blood glucose and HbA1c did not match. METHODS:Overall, 64 553 people with...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12823
更新日期:2018-12-01 00:00:00