Abstract:
BACKGROUND:Elevated blood or urinary concentrations of endocrine-disrupting chemicals (EDCs) may be related to increased risk of type 2 diabetes (T2D). The aim of the present study was to assess the role of EDCs in affecting risk of T2D and related metabolic traits. METHODS:MEDLINE was searched for cross-sectional and prospective studies published before 8 March 2014 into the association between EDCs (dioxin, polychlorinated biphenyl [PCB], chlorinated pesticide, bisphenol A [BPA], phthalate) and T2D and related metabolic traits. Three investigators independently extracted information on study design, participant characteristics, EDC types and concentrations, and association measures. RESULTS:Forty-one cross-sectional and eight prospective studies from ethnically diverse populations were included in the analysis. Serum concentrations of dioxins, PCBs, and chlorinated pesticides were significantly associated with T2D risk; comparing the highest to lowest concentration category, the pooled relative risks (RR) were 1.91 (95% confidence interval [CI] 1.44-2.54) for dioxins, 2.39 (95% CI 1.86-3.08) for total PCBs, and 2.30 (95% CI 1.81-2.93) for chlorinated pesticides. Urinary concentrations of BPA and phthalates were also associated with T2D risk; comparing the highest to lowest concentration categories, the pooled RR were 1.45 (95% CI 1.13-1.87) for BPA and 1.48 (95% CI 0.98-2.25) for phthalates. Further, EDC concentrations were associated with indicators of impaired fasting glucose and insulin resistance. CONCLUSIONS:Persistent and non-persistent EDCs may affect the risk of T2D. There is an urgent need for further investigation of EDCs, especially non-persistent ones, and T2D risk in large prospective studies.
journal_name
J Diabetesjournal_title
Journal of diabetesauthors
Song Y,Chou EL,Baecker A,You NC,Song Y,Sun Q,Liu Sdoi
10.1111/1753-0407.12325subject
Has Abstractpub_date
2016-07-01 00:00:00pages
516-32issue
4eissn
1753-0393issn
1753-0407journal_volume
8pub_type
杂志文章,meta分析,评审abstract:BACKGROUND:Diabetes mellitus affects the systolic and diastolic function of the left ventricle (LV). The aim of the present study was to evaluate the index of myocardial performance (IMP), a new Doppler index, in asymptomatic, normotensive patients with type 2 diabetes mellitus (T2DM). METHODS:The study population con...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2008.00005.x
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:The higher probability of type 2 diabetes mellitus (T2DM) in the Uygur population is due to a greater waist: hip ratio and visceral fat. This study investigated DNA methylation of tumor necrosis factor-α (TNF), monocyte chemoattractant protein-1 (MCP1), and adiponectin (ADIPOQ) in visceral adipose tissue in...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12478
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:In addition to its glucoregulatory actions, exendin-4, a stable glucagon-like peptide-1 receptor agonist, exhibits protective effects in the pancreas and anti-obesity effects. Suitable combination treatment with other anti-obesity or pancreas protective agents would be an effective approach to optimize these...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2012.00227.x
更新日期:2013-06-01 00:00:00
abstract::Diabetes mellitus is a metabolic disease with a considerable impact on healthcare owing to its increased prevalence and high mortality rate. Structural, morphological, and physiological changes in each of the ocular components have been described in detail. Autofluorescence has been described as a good indicator of me...
journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/1753-0407.12423
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Although diabetes is associated with ethnicity and worse cardiac surgery outcomes, no research has been done to study the effect of both diabetes and ethnicity on cardiac surgery outcomes in a multiethnic Southeast Asian cohort. Hence, this study aimed to delineate the association of ethnicity on outcomes af...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12961
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Considerable uncertainty remains about obstructive lung function( OLF) in adults with metabolic syndrome (MetS). The aim of the present study was to examine pulmonary function status in adults with and without MetS. METHODS:We used data from 3109 participants aged ≥20 years of the National Health and Nutrit...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12136
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic β-cells are destroyed by infiltrating immune cells. Bilateral cooperation of pancreatic β-cells and immune cells has been proposed in the progression of T1D, but as yet no systems study has investigated this possibility. The aims of the study...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12483
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Adipocyte fatty acid-binding protein (A-FABP) has been recognized as an important player in macrophage cholesterol trafficking and inflammation, and may promote the development of atherosclerosis. To further elucidate the role of A-FABP in atherosclerosis in diabetes, we investigated the relationship between...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12549
更新日期:2018-06-01 00:00:00
abstract::Two years ago, data presented at the annual American Diabetes Association (ADA) meeting in New Orleans showed a marked decrease in deaths, especially those due to cardiovascular disease, with the use of empagliflozin. Two major questions have been asked: (i) was the result a fluke; and (ii) was it a class effect, or w...
journal_title:Journal of diabetes
pub_type: 社论
doi:10.1111/1753-0407.12583
更新日期:2017-11-01 00:00:00
abstract::This article reviews the known pathophysiological mechanisms of comorbid gastroesophageal reflux disease (GERD) in the diabetic patient, discusses therapeutic options in care, and provides an approach to its evaluation and management. We searched for review articles published in the past 10 years through a PubMed sear...
journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/1753-0407.12279
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND: Diabetic peripheral neuropathy (DPN) is one of the complications of type 2 diabetes mellitus (T2DM) that decreases the quality of life of T2DM patients. Very few studies have found an association between the development and progression of DPN in T2DM and angiotensin-converting enzyme (ACE) gene insertion/d...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2012.00205.x
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:G protein-coupled receptor kinase-2 (GRK2) has been shown as a key regulator of cardiac function, and the myocardial GRK2 levels are mirrored by the levels in peripheral blood mononuclear cells (PBMCs). In this study, we evaluated the myocardial and PBMCs GRK2 levels in early diabetic cardiomyopathy (DCM). ...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12991
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:The aim of the present retrospective observational study was to examine the effect of interleukin-2 receptor antagonists (IL-2Ra) on new-onset diabetes after transplantation (NODAT) in liver transplant recipients. METHODS:Pre- and postoperative clinical data of 781 patients undergoing liver transplantation ...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12356
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Proprotein convertase subtilisin/kexin-type 9 (PCSK9) downregulates clearance of plasma cholesterol by liver. Its inactivation increases this clearance, reducing cardiovascular risk. However, a lack of PCSK9 could also lead to cholesterol accumulation in pancreatic islet beta cells, impairing insulin secreti...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12139
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Limited information exists regarding the efficacy of pregabalin in Chinese patients with painful diabetic peripheral neuropathy (pDPN). METHODS:An 11-week double-blind placebo-controlled trial was performed in Chinese pDPN patients randomized (1 : 1) to 300 mg/day pregabalin or placebo. The primary outcome ...
journal_title:Journal of diabetes
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/1753-0407.12585
更新日期:2018-03-01 00:00:00
abstract::Highlights A large retrospective study indicates no association between GDM and most types of cancer; this is in contrast to a few smaller studies that have suggested an association with cancer. An increased risk of thyroid cancer in mothers with GDM was demonstrated. While this risk requires further investigation, it...
journal_title:Journal of diabetes
pub_type: 信件
doi:10.1111/1753-0407.12988
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:To address the prognostic value of combining tubular basement membrane (TBM) and glomerular basement membrane (GBM) thickness in diabetic nephropathy (DN). METHODS:This retrospective study enrolled 110 patients with type 2 diabetes and biopsy-proven DN from 2011 to 2018. The pathological findings were confi...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.13150
更新日期:2020-12-22 00:00:00
abstract:BACKGROUND:Cross-sectional studies have supported the association among depression, obesity, and type 2 diabetes, but the causality remains controversial in Chinese adults. In this longitudinal study, we evaluated the synergistic effect of depression and obesity on the risk of type 2 diabetes. METHODS:This study inclu...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12968
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Patients with diabetes mellitus (DM) are more likely to develop in-hospital complications (IHCs) than patients without DM. In addition, they have poorer outcomes after an ischemic stroke (IS). Our goal was to evaluate whether the increase in risk for the development of IHCs in patients with IS is due to DM p...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12222
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Erectile dysfunction (ED) is a prevalent complication of diabetes, and oxidative stress is an important feature of diabetic ED. Oxidative stress-induced damage plays a pivotal role in the development of tissue alterations. However, the deleterious effects of oxidative stress in the corpus cavernosum with the...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12181
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:A1c, a surrogate measure of glycemic control, is known to have a strong linear correlation with mean plasma glucose (MPG) when analyzed in populations of patients. However, clinically significant intersubject variability in this relationship exists, which suggests that A1c measurements may not reflect actual...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2010.00066.x
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Supervised treadmill exercise is the recommended therapy for peripheral arterial disease (PAD) patients with intermittent claudication (IC). However, most PAD patients do not exhibit typical symptoms of IC. The aim of the present study was to explore the efficacy and safety of intensive walking exercise in P...
journal_title:Journal of diabetes
pub_type: 杂志文章,meta分析,评审
doi:10.1111/1753-0407.12304
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:With the current obesity epidemic, the search for effective weight loss approaches is required. In the present study, changes in weight, body composition and cardiovascular (CV) risk in response to a low-fat, reduced-energy diet (LFRE), a low-carbohydrate/high-protein diet (LCHP), or a commercially available...
journal_title:Journal of diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1753-0407.2009.00033.x
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to assess the quality of diabetes care and characteristics of the healthcare system in underdeveloped rural mountain areas of western China. METHODS:Questionnaires were used to collect data from 288 diabetic patients with a multistage cluster sampling method in Zhongjiang Co...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12433
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome (MetS) is highly prevalent worldwide, and its individual components obesity, diabetes, and hypertension have been identified as risk factors to develop severe coronavirus disease 2019 (COVID-19); however, data on MetS and clinical outcomes in COVID-19 are scarce. This study aims to determi...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.13157
更新日期:2021-01-16 00:00:00
abstract:BACKGROUND:Liver X receptors (LXRs) including LXRα and LXRβ are members of the nuclear hormone receptor superfamily of ligand activated transcription factors, which serve as lipid sensors to regulate expression of genes controlling many aspects of cholesterol and fatty acid metabolism. The liver is the central organ in...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12081
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Primary care physicians frequently encounter people with type 2 diabetes mellitus (T2DM) with discordant values for fasting glucose and HbA1c. The aim of this study was to identify the prevalence and characteristics of people in whom blood glucose and HbA1c did not match. METHODS:Overall, 64 553 people with...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12823
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:There is little information on medication use, trends across time, and the impact of guidelines on appropriate use of antidiabetic drugs in participants with type 2 diabetes mellitus (T2DM) with chronic kidney disease (CKD). METHODS:A cross-sectional analysis of the National Health and Nutrition Examination...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.13003
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Intrahepatic expression of dipeptidyl peptidase-4 (DPP4), and circulating DPP4 (cDPP4) levels and its enzymatic activity, are increased in non-alcoholic fatty liver disease (NAFLD) and in type 2 diabetes mellitus and/or obesity. DPP4 has been implicated as a causative factor in NAFLD progression but few stud...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12237
更新日期:2015-11-01 00:00:00
abstract::Following on from impressive economic development and urbanization, China is currently experiencing a high prevalence of metabolic syndrome. Patients with metabolic syndrome suffer from the "The Deadly Quartet" of hyperglycemia, hypertriglyceridemia, hypertension, and central (or upper body) obesity. Current treatment...
journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/j.1753-0407.2010.00090.x
更新日期:2010-12-01 00:00:00