Abstract:
BACKGROUND:To address the prognostic value of combining tubular basement membrane (TBM) and glomerular basement membrane (GBM) thickness in diabetic nephropathy (DN). METHODS:This retrospective study enrolled 110 patients with type 2 diabetes and biopsy-proven DN from 2011 to 2018. The pathological findings were confirmed according to the Renal Pathology Society classifications. GBM and TBM thicknesses were determined using the Haas' direct measurement/arithmetic mean method and orthogonal intercept method, respectively. Cox proportional hazard models were used to investigate the hazard ratios (HRs) for the influence of combined GBM and TBM thickness for predicting end-stage renal disease (ESRD). RESULTS:Patients were assigned to three groups according to the median GBM and TBM thickness: GBMlo TBMlo (GBM < 681 nm and TBM < 1200 nm), GBMhi TBMlo /GBMlo TBMhi (GBM ≥ 681 nm and TBM < 1200 nm, or GBM < 681 nm and TBM ≥ 1200 nm), and GBMhi TBMhi (GBM ≥ 681 nm and TBM ≥ 1200 nm). The GBMhi TBMlo /GBMlo TBMhi and GBMhi TBMhi groups displayed poorer renal function, a more severe glomerular classification and interstitial inflammation, and poorer renal survival rates than the GBMlo TBMlo group The GBMhi TBMlo /GBMlo TBMhi and GBMhi TBMhi groups had adjusted HRs of 1.49 (95% confidence interval [CI], 1.21-9.75) and 3.07 (95% CI, 2.87-12.78), respectively, compared with the GBMlo TBMlo group. CONCLUSIONS:TBM thickness enhanced GBM thickness for renal prognosis in patients with type 2 diabetes.
journal_name
J Diabetesjournal_title
Journal of diabetesauthors
Zhao L,Zhang J,Lei S,Ren H,Zou Y,Bai L,Zhang R,Xu H,Li L,Zhao Y,Cooper ME,Tong N,Zhang J,Liu Fdoi
10.1111/1753-0407.13150subject
Has Abstractpub_date
2020-12-22 00:00:00eissn
1753-0393issn
1753-0407pub_type
杂志文章abstract::This article reviews the known pathophysiological mechanisms of comorbid gastroesophageal reflux disease (GERD) in the diabetic patient, discusses therapeutic options in care, and provides an approach to its evaluation and management. We searched for review articles published in the past 10 years through a PubMed sear...
journal_title:Journal of diabetes
pub_type: 杂志文章,评审
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journal_title:Journal of diabetes
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journal_title:Journal of diabetes
pub_type: 杂志文章
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更新日期:2021-01-16 00:00:00
abstract:BACKGROUND:There is a wide variety of dressings currently available for the treatment of diabetic foot ulcers (DFUs). Because of a lack of evidence from head-to-head randomized controlled trials (RCTs), the relative effects of these dressings in DFU patients remain unclear. This study compared the efficacy of nine dres...
journal_title:Journal of diabetes
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journal_title:Journal of diabetes
pub_type: 杂志文章
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journal_title:Journal of diabetes
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章,随机对照试验
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更新日期:2019-09-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of diabetes
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-09-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章,随机对照试验
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更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Brown adipose tissue (BAT) has been regarded as a potential target organ to combat obesity and related metabolic disorders. However, the effect of BAT activation on the development of diabetic kidney disease (DKD) remains unclear. METHODS:Diabetic mice were induced by streptozotocin (STZ) combined with a hi...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12938
更新日期:2019-12-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12957
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Elevated blood or urinary concentrations of endocrine-disrupting chemicals (EDCs) may be related to increased risk of type 2 diabetes (T2D). The aim of the present study was to assess the role of EDCs in affecting risk of T2D and related metabolic traits. METHODS:MEDLINE was searched for cross-sectional and...
journal_title:Journal of diabetes
pub_type: 杂志文章,meta分析,评审
doi:10.1111/1753-0407.12325
更新日期:2016-07-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 信件
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更新日期:2017-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章,评审
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更新日期:2020-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12433
更新日期:2017-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章,评审
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journal_title:Journal of diabetes
pub_type: 杂志文章
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更新日期:2012-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:In addition to its glucoregulatory actions, exendin-4, a stable glucagon-like peptide-1 receptor agonist, exhibits protective effects in the pancreas and anti-obesity effects. Suitable combination treatment with other anti-obesity or pancreas protective agents would be an effective approach to optimize these...
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pub_type: 杂志文章
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