Association of characteristics of people with type 2 diabetes mellitus with discordant values of fasting glucose and HbA1c.

abstract：BACKGROUND:Glucagon-like peptide-1 (GLP-1) analogues have emerged as insulin secretagogues and are widely used in type 2 diabetic patients. GLP-1 analogues also demonstrate a promotion of beta cell proliferation and reduction of apoptosis in rodents. In the present study, we investigated the protection of pancreatic be...

journal_title：Journal of diabetes

authors： Luo X,Pan L,Nie A,Wang Q,Gu Y,Li F,Zhang H,Li W,Li X

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Women with previous gestational diabetes mellitus (pGDM) are at increased risk of developing type 2 diabetes later in life. The aim of this study was to determine if circulating levels of metabolic hormones 12 weeks following a GDM pregnancy are associated with an increased risk of type 2 diabetes 8-10 years...

journal_title：Journal of diabetes

authors： Lappas M,Jinks D,Ugoni A,Louizos CC,Permezel M,Georgiou HM

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Limited information exists regarding the efficacy of pregabalin in Chinese patients with painful diabetic peripheral neuropathy (pDPN). METHODS:An 11-week double-blind placebo-controlled trial was performed in Chinese pDPN patients randomized (1 : 1) to 300 mg/day pregabalin or placebo. The primary outcome ...

journal_title：Journal of diabetes

authors： Mu Y,Liu X,Li Q,Chen K,Liu Y,Lv X,Xu X,Fan D,Shang N,Yang R,Pauer L,Pan C

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:In addition to its glucoregulatory actions, exendin-4, a stable glucagon-like peptide-1 receptor agonist, exhibits protective effects in the pancreas and anti-obesity effects. Suitable combination treatment with other anti-obesity or pancreas protective agents would be an effective approach to optimize these...

journal_title：Journal of diabetes

authors： Patel V,Joharapurkar A,Gandhi T,Patel K,Dhanesha N,Kshirsagar S,Dhote V,Detroja J,Bahekar R,Jain M

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Cross-sectional studies have reported a close association between serum lipopolysaccharide-binding protein (LBP) and many metabolic disorders. However, no longitudinal study has explored the relationship between LBP and type 2 diabetes mellitus (T2DM). The aim of the present study was to investigate the asso...

journal_title：Journal of diabetes

authors： Zhou H,Hu J,Zhu Q,Yang S,Zhang Y,Gao R,Liu L,Wang Y,Zhen Q,Lv Q,Li Q

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:To evaluate the association between thyroid autoimmunity and psychiatric disorders (depression, anxiety, eating disorder, schizophrenia or attention-deficit/hyperactivity disorder) among adolescents and young adults with type 1 diabetes (11-25 years). METHODS:We compared 9368 type 1 diabetes patients with t...

journal_title：Journal of diabetes

authors： Eckert A,Galler A,Papsch M,Hess M,Holder M,Döing C,Bierkamp-Christophersen D,Hammer E,Pappa A,Lanzinger S

更新日期：2020-12-16 00:00:00

abstract：BACKGROUND:In people with chronic kidney disease (CKD), HbA1c may be a problematic measure of glycemic control. Glycated albumin and fructosamine have been proposed as better markers of hyperglycemia in CKD. In the present study we investigated associations of HbA1c, glycated albumin, and fructosamine with fasting gluc...

journal_title：Journal of diabetes

authors： Jung M,Warren B,Grams M,Kwong YD,Shafi T,Coresh J,Rebholz CM,Selvin E

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:The aims of the present study were to examine the association of cigarette smoking and alcohol consumption with impaired β-cell function in Chinese men, particularly the interaction of smoking and alcohol consumption on impaired insulin secretion. METHODS:A population-based cross-sectional study was perform...

journal_title：Journal of diabetes

authors： Xu M,Zhou Y,Xu B,Sun J,Wang T,Lu J,Lai S,Bi Y,Wang W,Ning G

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Intrahepatic expression of dipeptidyl peptidase-4 (DPP4), and circulating DPP4 (cDPP4) levels and its enzymatic activity, are increased in non-alcoholic fatty liver disease (NAFLD) and in type 2 diabetes mellitus and/or obesity. DPP4 has been implicated as a causative factor in NAFLD progression but few stud...

journal_title：Journal of diabetes

authors： Williams KH,Vieira De Ribeiro AJ,Prakoso E,Veillard AS,Shackel NA,Brooks B,Bu Y,Cavanagh E,Raleigh J,McLennan SV,McCaughan GW,Keane FM,Zekry A,Gorrell MD,Twigg SM

更新日期：2015-11-01 00:00:00

abstract：:There has been a rapid escalation of type 2 diabetes (T2D) in developing countries, with varied prevalence according to rural vs urban habitat and degree of urbanization. Some ethnic groups (eg, South Asians, other Asians, and Africans), develop diabetes a decade earlier and at a lower body mass index than Whites, hav...

journal_title：Journal of diabetes

authors： Misra A,Gopalan H,Jayawardena R,Hills AP,Soares M,Reza-Albarrán AA,Ramaiya KL

更新日期：2019-07-01 00:00:00

abstract：:Crossover design has been widely used in late-phase clinical studies, as well as in pharmacokinetic and pharmacodynamic, bioequivalence, and medical device studies; however, its interpretability and applicability continue to be debated. Herein we provide discussions around a crossover design's scientific benefit, appl...

journal_title：Journal of diabetes

authors： Wang T,Malone J,Fu H,Heilmann C,Qu Y,Huster WJ

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Erectile dysfunction (ED) is a prevalent complication of diabetes, and oxidative stress is an important feature of diabetic ED. Oxidative stress-induced damage plays a pivotal role in the development of tissue alterations. However, the deleterious effects of oxidative stress in the corpus cavernosum with the...

journal_title：Journal of diabetes

authors： Castela A,Gomes P,Domingues VF,Paíga P,Costa R,Vendeira P,Costa C

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:It is clear that aerobic training (AT) can delay pancreatic exhaustion and slow the progression from prediabetes to type 2 diabetes (T2D), but there is little information regarding the effects of resistance training (RT) in people with prediabetes. This study compared the effectiveness of RT and AT in improv...

journal_title：Journal of diabetes

authors： Yuan X,Dai X,Liu L,Hsue C,Miller JD,Fang Z,Li J,Feng J,Huang Y,Liu C,Shen J,Chen T,Liu Y,Mordes J,Lou Q

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Uncontrolled diabetes mellitus causes neuronal damage because of increased intracellular glucose. Natural products as complementary therapy may reduce neuronal complications. This study investigated whether fish oil (FO) and wheat germ oil (WGO) supplementation protects the brain in streptozotocin (STZ)-indu...

journal_title：Journal of diabetes

authors： Khedr NF

更新日期：2017-11-01 00:00:00

abstract：:This article reviews the known pathophysiological mechanisms of comorbid gastroesophageal reflux disease (GERD) in the diabetic patient, discusses therapeutic options in care, and provides an approach to its evaluation and management. We searched for review articles published in the past 10 years through a PubMed sear...

journal_title：Journal of diabetes

authors： Punjabi P,Hira A,Prasad S,Wang X,Chokhavatia S

更新日期：2015-09-01 00:00:00

abstract：:Following on from impressive economic development and urbanization, China is currently experiencing a high prevalence of metabolic syndrome. Patients with metabolic syndrome suffer from the "The Deadly Quartet" of hyperglycemia, hypertriglyceridemia, hypertension, and central (or upper body) obesity. Current treatment...

journal_title：Journal of diabetes

authors： Xia X,Weng J

更新日期：2010-12-01 00:00:00

abstract：:Adenosine triphosphate (ATP) synthesis and release in mitochondria play critical roles in regulating insulin secretion in pancreatic β cells. Mitochondrial dysfunction is mainly characterized by a decrease in ATP production, which is a central event in the progression of pancreatic β cell dysfunction and diabetes. ATP...

journal_title：Journal of diabetes

authors： Wang C,Geng B,Cui Q,Guan Y,Yang J

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to assess the quality of diabetes care and characteristics of the healthcare system in underdeveloped rural mountain areas of western China. METHODS:Questionnaires were used to collect data from 288 diabetic patients with a multistage cluster sampling method in Zhongjiang Co...

journal_title：Journal of diabetes

authors： Ke L,Zhang Y,Wang X,Li S,Yang W,Tong N

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Asia is experiencing a type 2 diabetes epidemic, but prevalence differs by ethnicity and level of socioeconomic development. Singapore and Mauritius have implemented comprehensive campaigns to address this public health problem. We compared diabetes and obesity prevalence trends among Chinese and South Asian...

journal_title：Journal of diabetes

authors： Tan KHX,Barr ELM,Koshkina V,Ma S,Kowlessur S,Magliano DJ,Söderberg S,Chia KS,Zimmet P,Lim WY

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The higher probability of type 2 diabetes mellitus (T2DM) in the Uygur population is due to a greater waist:  hip ratio and visceral fat. This study investigated DNA methylation of tumor necrosis factor-α (TNF), monocyte chemoattractant protein-1 (MCP1), and adiponectin (ADIPOQ) in visceral adipose tissue in...

journal_title：Journal of diabetes

authors： Zhang J,Wang C,Ha X,Li W,Xu P,Gu Y,Wang T,Wang Y,Xie J

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:The present study investigated the correlation between urinary α1 -microglobulin as a marker of tubular dysfunction and albumin excretion in children and adolescents with type 1 diabetes (T1D). METHODS:Ninety-two Egyptian patients with T1D were included in the study (mean [± SD] age 14.14 ± 5.13 years). The...

journal_title：Journal of diabetes

authors： Saif A,Soliman N

更新日期：2017-01-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) is the primary incretin hormone secreted from the intestine upon uptake of food to stimulate insulin secretion from pancreatic β-cells. GLP-1 exerts its effects by binding to its G-protein coupled receptors and subsequently activating adenylate cyclase, leading to generation of cyclic a...

journal_title：Journal of diabetes

authors： Ma X,Guan Y,Hua X

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Proprotein convertase subtilisin/kexin-type 9 (PCSK9) downregulates clearance of plasma cholesterol by liver. Its inactivation increases this clearance, reducing cardiovascular risk. However, a lack of PCSK9 could also lead to cholesterol accumulation in pancreatic islet beta cells, impairing insulin secreti...

journal_title：Journal of diabetes

authors： Mbikay M,Sirois F,Gyamera-Acheampong C,Wang GS,Rippstein P,Chen A,Mayne J,Scott FW,Chrétien M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:G protein-coupled receptor kinase-2 (GRK2) has been shown as a key regulator of cardiac function, and the myocardial GRK2 levels are mirrored by the levels in peripheral blood mononuclear cells (PBMCs). In this study, we evaluated the myocardial and PBMCs GRK2 levels in early diabetic cardiomyopathy (DCM). ...

journal_title：Journal of diabetes

authors： Lai S,Fu X,Yang S,Zhang S,Lin Q,Zhang M,Chen H

更新日期：2020-03-01 00:00:00

abstract：:Two years ago, data presented at the annual American Diabetes Association (ADA) meeting in New Orleans showed a marked decrease in deaths, especially those due to cardiovascular disease, with the use of empagliflozin. Two major questions have been asked: (i) was the result a fluke; and (ii) was it a class effect, or w...

journal_title：Journal of diabetes

authors： Drexler A

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:With the current obesity epidemic, the search for effective weight loss approaches is required. In the present study, changes in weight, body composition and cardiovascular (CV) risk in response to a low-fat, reduced-energy diet (LFRE), a low-carbohydrate/high-protein diet (LCHP), or a commercially available...

journal_title：Journal of diabetes

authors： Rolland C,Hession M,Murray S,Wise A,Broom I

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Convincing evidence indicates that the consumption of inulin-type fructans, inulin, and oligofructose has beneficial effects on blood glucose changes in animal models, although data in humans have been considered equivocal. As such, a systematic review of available literature on humans was conducted to evalu...

journal_title：Journal of diabetes

authors： Bonsu NK,Johnson CS,McLeod KM

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:Dipeptidyl peptidase-4 (DPP-4) is responsible for degradation of glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP), the endogenous incretins that stimulate glucose-dependent insulin secretion. The objective was to evaluate preclinical profile of a novel DPP-4 inhibitor ZYDPLA1. METHODS...

journal_title：Journal of diabetes

authors： Jain MR,Joharapurkar AA,Bahekar RH,Patel H,Jadav P,Kshirsagar SG,Patel VJ,Patel KN,Ramanathan VK,Patel PR,Desai RC

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:The aim of the present retrospective observational study was to examine the effect of interleukin-2 receptor antagonists (IL-2Ra) on new-onset diabetes after transplantation (NODAT) in liver transplant recipients. METHODS:Pre- and postoperative clinical data of 781 patients undergoing liver transplantation ...

journal_title：Journal of diabetes

authors： Xue M,Lv C,Chen X,Huang X,Sun Q,Wang T,Liang J,Zhang Y,He S,Gao J,Zhou J,Yu M,Fan J,Gao X

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:A1c, a surrogate measure of glycemic control, is known to have a strong linear correlation with mean plasma glucose (MPG) when analyzed in populations of patients. However, clinically significant intersubject variability in this relationship exists, which suggests that A1c measurements may not reflect actual...

journal_title：Journal of diabetes

authors： Shrom D,Sarwat S,Ilag L,Bloomgarden ZT

更新日期：2010-06-01 00:00:00