Abstract:
BACKGROUND:Metabolic syndrome (MetS) is highly prevalent worldwide, and its individual components obesity, diabetes, and hypertension have been identified as risk factors to develop severe coronavirus disease 2019 (COVID-19); however, data on MetS and clinical outcomes in COVID-19 are scarce. This study aims to determine association between MetS and severe disease outcomes, that is, mortality, need for mechanical ventilation, and intensive care unit (ICU) requirement among patients with COVID-19. METHODS:This is a retrospective multihospital cohort study on 1871 patients with confirmed COVID-19 diagnosis. Patient data including demographics, comorbidities, body mass index (BMI), smoking, laboratory data, and the clinical course of hospitalization were collected. Multivariable regression was performed adjusting for age, sex, race, insurance, smoking, and comorbidities. RESULTS:A total of 1871 patients (median age 66 [interquartile range, IQR 54-75]; 965 (51.6%) males; 1494 (80%) African Americans; median BMI 29.4 kg/m2 [IQR 25-35.8]; 573 (30.6%) patients with MetS) were included. Patients with MetS had increased mortality (odds ratio [OR], 1.40; 95% CI, 1.11-1.75; P = .004), higher ICU admission (OR, 1.68; 95% CI, 1.36-2.08; P < .001), and increased need for mechanical ventilation (OR, 1.90; 95% CI, 1.52-2.37; P < .001). Among individual comorbidities, diabetes had significant association with mortality (OR, 1.30; 95% CI, 1.05-1.63; P = 0.02), ICU admission (OR, 1.56; 95% CI, 1.27-1.93; P < .001), and need for mechanical ventilation (OR, 1.63; 95% CI, 1.30-2.03; P < .001). CONCLUSIONS:MetS is a better prognostic indicator for severe disease outcomes in patients with COVID-19 than its individual components. Patients with MetS had significantly higher mortality, increased ICU admissions, and need for mechanical ventilation.
journal_name
J Diabetesjournal_title
Journal of diabetesauthors
Lohia P,Kapur S,Benjaram S,Pandey A,Mir T,Seyoum Bdoi
10.1111/1753-0407.13157subject
Has Abstractpub_date
2021-01-16 00:00:00eissn
1753-0393issn
1753-0407pub_type
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journal_title:Journal of diabetes
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pub_type: 杂志文章
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pub_type: 杂志文章
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doi:10.1111/1753-0407.12261
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pub_type: 杂志文章
doi:10.1111/1753-0407.12549
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doi:10.1111/1753-0407.12337
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pub_type: 杂志文章,随机对照试验
doi:10.1111/1753-0407.12902
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pub_type: 杂志文章
doi:10.1111/j.1753-0407.2011.00118.x
更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of diabetes
pub_type: 杂志文章,随机对照试验
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更新日期:2009-09-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/1753-0407.12827
更新日期:2019-02-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12518
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