Angiotensin-converting enzyme (ACE) gene II genotype protects against the development of diabetic peripheral neuropathy in type 2 diabetes mellitus.

abstract：:Pancreatic β-cells secrete insulin when blood glucose levels become high; however, when β-cells are chronically exposed to hyperglycemia, β-cell function gradually deteriorates, which is known as β-cell glucose toxicity. In the diabetic state, nuclear expression of the pancreatic transcription factors pancreatic and d...

journal_title：Journal of diabetes

authors： Kaneto H,Matsuoka TA,Kimura T,Obata A,Shimoda M,Kamei S,Mune T,Kaku K

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:With the current obesity epidemic, the search for effective weight loss approaches is required. In the present study, changes in weight, body composition and cardiovascular (CV) risk in response to a low-fat, reduced-energy diet (LFRE), a low-carbohydrate/high-protein diet (LCHP), or a commercially available...

journal_title：Journal of diabetes

authors： Rolland C,Hession M,Murray S,Wise A,Broom I

更新日期：2009-09-01 00:00:00

abstract：:Islet transplantation is an attractive concept for the treatment of Type 1 diabetes because of its potential high efficacy and minimal invasion to patients. The treatment may effectively control blood glucose for brittle Type 1 diabetes, resulting in a marked reduction in hypoglycemic episodes and improvements in HbA1...

journal_title：Journal of diabetes

authors： Matsumoto S

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:This meta-analysis was performed to quantitatively evaluate the dose-response association between obstructive sleep apnea (OSA) and risk of type 2 diabetes mellitus (T2DM). METHODS:PubMed, Embase, and Web of Science were searched up to 12 December 2018 for articles that assessed the OSA-T2DM association. Ra...

journal_title：Journal of diabetes

authors： Qie R,Zhang D,Liu L,Ren Y,Zhao Y,Liu D,Liu F,Chen X,Cheng C,Guo C,Li Q,Zhou Q,Tian G,Han M,Huang S,Wu X,Qin P,Li J,Cao J,Zhang M,Huang J,Lu J,Li H,Wang J,Cheng R,Hu D

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:The association between dental caries and metabolic syndrome (MetS) is inconsistent. The aim of the present study was to assess the relationship between dental caries and MetS and its components in a middle-aged Chinese population. METHODS:A cross-sectional analysis was performed of 13 998 participants aged...

journal_title：Journal of diabetes

authors： Cao X,Wang D,Zhou J,Yuan H,Chen Z

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Erectile dysfunction (ED) is a prevalent complication of diabetes, and oxidative stress is an important feature of diabetic ED. Oxidative stress-induced damage plays a pivotal role in the development of tissue alterations. However, the deleterious effects of oxidative stress in the corpus cavernosum with the...

journal_title：Journal of diabetes

authors： Castela A,Gomes P,Domingues VF,Paíga P,Costa R,Vendeira P,Costa C

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:An increase in the prevalence of type 2 diabetes mellitus occurs in immigrants from developing regions to Western countries. However, the dynamics of these transitions in relation to the duration of residence in the new environment are not clearly defined. METHODS:Data concerning cardiovascular risk factors...

journal_title：Journal of diabetes

authors： Kalchiem-Dekel O,Shai I,Biderman A,Orenstein A,Cicurel A,Reuven Y,Henkin Y

更新日期：2015-07-01 00:00:00

abstract：:Two years ago, data presented at the annual American Diabetes Association (ADA) meeting in New Orleans showed a marked decrease in deaths, especially those due to cardiovascular disease, with the use of empagliflozin. Two major questions have been asked: (i) was the result a fluke; and (ii) was it a class effect, or w...

journal_title：Journal of diabetes

authors： Drexler A

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:A1c, a surrogate measure of glycemic control, is known to have a strong linear correlation with mean plasma glucose (MPG) when analyzed in populations of patients. However, clinically significant intersubject variability in this relationship exists, which suggests that A1c measurements may not reflect actual...

journal_title：Journal of diabetes

authors： Shrom D,Sarwat S,Ilag L,Bloomgarden ZT

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Uncontrolled diabetes mellitus causes neuronal damage because of increased intracellular glucose. Natural products as complementary therapy may reduce neuronal complications. This study investigated whether fish oil (FO) and wheat germ oil (WGO) supplementation protects the brain in streptozotocin (STZ)-indu...

journal_title：Journal of diabetes

authors： Khedr NF

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Cross-sectional studies have supported the association among depression, obesity, and type 2 diabetes, but the causality remains controversial in Chinese adults. In this longitudinal study, we evaluated the synergistic effect of depression and obesity on the risk of type 2 diabetes. METHODS:This study inclu...

journal_title：Journal of diabetes

authors： Ning F,Zhang D,Xue B,Zhang L,Zhang J,Zhu Z,Zhang D,Gao R,Pang Z,Qiao Q,Qingdao Diabetes Prevention Program.

更新日期：2020-02-01 00:00:00

abstract：:Highlights A large retrospective study indicates no association between GDM and most types of cancer; this is in contrast to a few smaller studies that have suggested an association with cancer. An increased risk of thyroid cancer in mothers with GDM was demonstrated. While this risk requires further investigation, it...

journal_title：Journal of diabetes

authors： Pace R,Rahme E,Dasgupta K

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Diabetes is a risk factor for various cancers, but its prognostic role in renal cell carcinoma (RCC) is controversial and understudied. This study investigated the prognostic value of type 2 diabetes (T2D) in RCC patients. METHODS:The clinicopathological and follow-up data of 451 RCC patients undergoing rad...

journal_title：Journal of diabetes

authors： Yang H,Yin K,Wang Y,Xia M,Zhang R,Wang W,Chen J,Wang C,Shuang W

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Insulin therapy should be strongly considered in newly diagnosed type 2 diabetic (T2D) patients with severe hyperglycemia. However, whether insulin be continued or patients switched to an oral antidiabetic drug (OAD) after short-term intensive insulin therapy (ITT) is not clear. METHODS:After ITT for 10-14 ...

journal_title：Journal of diabetes

authors： Cheng Q,Yang S,Zhao C,Wang Z,Feng Z,Li R,Ye P,Zhang S,Deng H,Zhou B,Long J,Gong L,Qing H,Luo C,Li Q

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Genome-wide association studies (GWAS) have identified several genetic variants affecting gestational glucose metabolism. However, information regarding their known associations with gestational diabetes mellitus (GDM) risk remains scarce. METHODS:This study examined the associations of 12 gestational gluco...

journal_title：Journal of diabetes

authors： Xie K,Zhang Y,Wen J,Chen T,Kong J,Zhang J,Wu X,Hu C,Xu B,Ji C,Guo X,Wu J

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:G protein-coupled receptor kinase-2 (GRK2) has been shown as a key regulator of cardiac function, and the myocardial GRK2 levels are mirrored by the levels in peripheral blood mononuclear cells (PBMCs). In this study, we evaluated the myocardial and PBMCs GRK2 levels in early diabetic cardiomyopathy (DCM). ...

journal_title：Journal of diabetes

authors： Lai S,Fu X,Yang S,Zhang S,Lin Q,Zhang M,Chen H

更新日期：2020-03-01 00:00:00

abstract：:Diabetes mellitus is a metabolic disease with a considerable impact on healthcare owing to its increased prevalence and high mortality rate. Structural, morphological, and physiological changes in each of the ocular components have been described in detail. Autofluorescence has been described as a good indicator of me...

journal_title：Journal of diabetes

authors： Calvo-Maroto AM,Perez-Cambrodi RJ,Garcia-Lazaro S,Ferrer-Blasco T,Cerviño A

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:To analyze the glycemic response of Indian patients with type2 diabetes mellitus (T2DM) to combination therapy with vildagliptin and metformin and compare our data with those of clinical trials. METHODS:In a retrospective study of the hospital database, the glycemic control of 280 patients with T2DM who wer...

journal_title：Journal of diabetes

authors： Chatterjee S,Chatterjee S

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Liver X receptors (LXRs) including LXRα and LXRβ are members of the nuclear hormone receptor superfamily of ligand activated transcription factors, which serve as lipid sensors to regulate expression of genes controlling many aspects of cholesterol and fatty acid metabolism. The liver is the central organ in...

journal_title：Journal of diabetes

authors： Zhang X,Liu J,Su W,Wu J,Wang C,Kong X,Gustafsson JÅ,Ding J,Ma X,Guan Y

更新日期：2014-05-01 00:00:00

abstract：:Observations from clinical studies suggest that low serum levels of testosterone in men are often associated with obesity, insulin resistance, and metabolic compromise. Indeed, the clinical symptoms of late-onset hypogonadism are markedly similar to those of Type 2 diabetes mellitus (T2DM) and metabolic syndrome, and ...

journal_title：Journal of diabetes

authors： Jones TH

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic β-cells are destroyed by infiltrating immune cells. Bilateral cooperation of pancreatic β-cells and immune cells has been proposed in the progression of T1D, but as yet no systems study has investigated this possibility. The aims of the study...

journal_title：Journal of diabetes

authors： Safari-Alighiarloo N,Taghizadeh M,Tabatabaei SM,Shahsavari S,Namaki S,Khodakarim S,Rezaei-Tavirani M

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Intrahepatic expression of dipeptidyl peptidase-4 (DPP4), and circulating DPP4 (cDPP4) levels and its enzymatic activity, are increased in non-alcoholic fatty liver disease (NAFLD) and in type 2 diabetes mellitus and/or obesity. DPP4 has been implicated as a causative factor in NAFLD progression but few stud...

journal_title：Journal of diabetes

authors： Williams KH,Vieira De Ribeiro AJ,Prakoso E,Veillard AS,Shackel NA,Brooks B,Bu Y,Cavanagh E,Raleigh J,McLennan SV,McCaughan GW,Keane FM,Zekry A,Gorrell MD,Twigg SM

更新日期：2015-11-01 00:00:00

abstract：:Skin autofluorescence is increased in diabetes, rises with age, and predicts diabetes-related complications. Exposure to secondhand smoke, because one or more family members are smokers, further increases skin autofluorescence in children and young adults with type 1 diabetes. Elimination of passive smoking should be ...

journal_title：Journal of diabetes

authors： Vollenbrock CE,Van Waateringe RP,Veeze HJ,Aanstoot HJ,Wolffenbuttel BH

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Few studies have focused on postprandial incretin responses to different carbohydrate meals. Therefore, we designed a study to compare the different effects of two carbohydrates (75 g oral glucose, a monosaccharide and 100 g standard noodle, a polysaccharide, with 75 g carbohydrates equivalently) on postpran...

journal_title：Journal of diabetes

authors： Deng Y,Zhang Y,Zheng S,Hong J,Wang C,Liu T,Sun Z,Gu W,Gu Y,Shi J,Yao S,Wang W,Ning G

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:There is little information on medication use, trends across time, and the impact of guidelines on appropriate use of antidiabetic drugs in participants with type 2 diabetes mellitus (T2DM) with chronic kidney disease (CKD). METHODS:A cross-sectional analysis of the National Health and Nutrition Examination...

journal_title：Journal of diabetes

authors： Gor D,Gerber BS,Walton SM,Lee TA,Nutescu EA,Touchette DR

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Mitogen-inducible gene 6 (Mig-6) has an important role in the regulation of cholesterol homeostasis and bile acid synthesis. However, the physiological functions of Mig-6 in the liver remain poorly understood. METHODS:To investigate Mig-6 functioning in the liver, we used conditionally ablated Mig-6 using t...

journal_title：Journal of diabetes

authors： Yoo JY,Kim TH,Kong S,Lee JH,Choi W,Kim KS,Kim HJ,Jeong JW,Ku BJ

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Limited information exists regarding the efficacy of pregabalin in Chinese patients with painful diabetic peripheral neuropathy (pDPN). METHODS:An 11-week double-blind placebo-controlled trial was performed in Chinese pDPN patients randomized (1 : 1) to 300 mg/day pregabalin or placebo. The primary outcome ...

journal_title：Journal of diabetes

authors： Mu Y,Liu X,Li Q,Chen K,Liu Y,Lv X,Xu X,Fan D,Shang N,Yang R,Pauer L,Pan C

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:The aim of the present retrospective observational study was to examine the effect of interleukin-2 receptor antagonists (IL-2Ra) on new-onset diabetes after transplantation (NODAT) in liver transplant recipients. METHODS:Pre- and postoperative clinical data of 781 patients undergoing liver transplantation ...

journal_title：Journal of diabetes

authors： Xue M,Lv C,Chen X,Huang X,Sun Q,Wang T,Liang J,Zhang Y,He S,Gao J,Zhou J,Yu M,Fan J,Gao X

更新日期：2016-07-01 00:00:00

abstract：:Crossover design has been widely used in late-phase clinical studies, as well as in pharmacokinetic and pharmacodynamic, bioequivalence, and medical device studies; however, its interpretability and applicability continue to be debated. Herein we provide discussions around a crossover design's scientific benefit, appl...

journal_title：Journal of diabetes

authors： Wang T,Malone J,Fu H,Heilmann C,Qu Y,Huster WJ

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Although niacin often has beneficial effects on the lipoprotein profile, flushing is an untoward effect associated with its use. Aspirin can only reduce the flushing response by 30-40%. Thus, the aim of the present study was to investigate the mechanisms of niacin-induced flushing, with and without aspirin, ...

journal_title：Journal of diabetes

authors： Parson HK,Harati H,Cooper D,Vinik AI

更新日期：2013-03-01 00:00:00