Abstract：
BACKGROUND:Although niacin often has beneficial effects on the lipoprotein profile, flushing is an untoward effect associated with its use. Aspirin can only reduce the flushing response by 30-40%. Thus, the aim of the present study was to investigate the mechanisms of niacin-induced flushing, with and without aspirin, in normal, healthy individuals. METHODS:Niacin-induced flushing was evaluated in 30 healthy individuals after oral administration of 1000 mg niacin alone or with 325 mg aspirin. Neurological, autonomic nervous system, and skin blood flow measurements (using laser Doppler on the glabrous and hairy skin of each participant) were made at various times after drug administration. In addition, the systemic release of 9α,11β-prostaglandin (PG) F(2) was determined. Flushing symptoms of redness, warmth, tingling, itching, and intensity were recorded using the modified Flushing ASsessment Tool (FAST). RESULTS:After aspirin, the mean flushing scores for all symptoms decreased significantly; however, 36-53% of participants still had some degree of symptoms, even though aspirin completely blocked 11β-PGF(2) synthesis. Maximum skin blood flow (MaxSkBF) in both the glabrous and hairy forearm increased significantly after niacin, but decreased significantly after aspirin only in hairy skin. Regression analysis showed that, in glabrous skin, both PGF(2) and parasympathetic activity were significant predictors of MaxSkBF after niacin, contributing 26% and 14%, respectively (total R(2) = 40%). CONCLUSIONS:The present study indicates, for the first time, that the parasympathetic nervous system, in addition to PGD(2) , may play an important role in niacin-induced flushing. Changing the sympathetic/parasympathetic balance in favor of parasympathetic activation may be a good therapeutic target to reduce niacin-induced flushing.
journal_name
J Diabetesjournal_title
Journal of diabetesauthors
Parson HK,Harati H,Cooper D,Vinik AIdoi
10.1111/j.1753-0407.2012.00216.xsubject
Has Abstractpub_date
2013-03-01 00:00:00pages
59-67issue
1eissn
1753-0393issn
1753-0407journal_volume
5pub_type
杂志文章abstract：BACKGROUND:The aim of the present study was to investigate whether the therapeutic efficacy of acarbose and metformin is correlated with baseline HbA1c levels in Chinese patients with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS:Data for 711 subjects were retrieved from the MARCH (Metformin and AcaRbose in...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/1753-0407.12337
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:It is clear that aerobic training (AT) can delay pancreatic exhaustion and slow the progression from prediabetes to type 2 diabetes (T2D), but there is little information regarding the effects of resistance training (RT) in people with prediabetes. This study compared the effectiveness of RT and AT in improv...
journal_title：Journal of diabetes
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/1753-0407.12955
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:The aim of the present retrospective observational study was to examine the effect of interleukin-2 receptor antagonists (IL-2Ra) on new-onset diabetes after transplantation (NODAT) in liver transplant recipients. METHODS:Pre- and postoperative clinical data of 781 patients undergoing liver transplantation ...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/1753-0407.12356
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Mitogen-inducible gene 6 (Mig-6) has an important role in the regulation of cholesterol homeostasis and bile acid synthesis. However, the physiological functions of Mig-6 in the liver remain poorly understood. METHODS:To investigate Mig-6 functioning in the liver, we used conditionally ablated Mig-6 using t...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/1753-0407.12261
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Patients with diabetes mellitus (DM) are more likely to develop in-hospital complications (IHCs) than patients without DM. In addition, they have poorer outcomes after an ischemic stroke (IS). Our goal was to evaluate whether the increase in risk for the development of IHCs in patients with IS is due to DM p...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/1753-0407.12222
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Type 2 diabetes mellitus (T2DM) treatment generally requires multiple antihyperglycemic agents. When diet, exercise, and treatment with sulfonylurea and metformin do not achieve glycemic goals, several options are available. The present study evaluated the efficacy and tolerability of sitagliptin 100 mg/day ...
journal_title：Journal of diabetes
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/1753-0407.12351
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:The aim of the present study was to determine the prevalence and risk factors of prediabetes and diagnosed and undiagnosed diabetes mellitus (DM) in rural Bangladesh. METHODS:Using a population-based cluster random sampling strategy, 3104 adults aged ≥30 years were recruited. Fasting capillary blood glucose...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/1753-0407.12294
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Glucose excursions and hypoglycemia are associated with cardiovascular complications. However, no studies have evaluated glucose excursions and the frequency of hypoglycemia in patients treated with mitiglinide/voglibose versus glimepiride as add-on to dipeptidyl peptidase-4 inhibitor therapy. METHODS:This ...
journal_title：Journal of diabetes
pub_type： 杂志文章,随机对照试验
doi：10.1111/1753-0407.12658
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Metabolic syndrome (MetS) is highly prevalent worldwide, and its individual components obesity, diabetes, and hypertension have been identified as risk factors to develop severe coronavirus disease 2019 (COVID-19); however, data on MetS and clinical outcomes in COVID-19 are scarce. This study aims to determi...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/1753-0407.13157
更新日期：2021-01-16 00:00:00
abstract：BACKGROUND:The aim of the present study was to assess the quality of diabetes care and characteristics of the healthcare system in underdeveloped rural mountain areas of western China. METHODS:Questionnaires were used to collect data from 288 diabetic patients with a multistage cluster sampling method in Zhongjiang Co...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/1753-0407.12433
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Cross-sectional studies have supported the association among depression, obesity, and type 2 diabetes, but the causality remains controversial in Chinese adults. In this longitudinal study, we evaluated the synergistic effect of depression and obesity on the risk of type 2 diabetes. METHODS:This study inclu...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/1753-0407.12968
更新日期：2020-02-01 00:00:00
abstract：:This article reviews the known pathophysiological mechanisms of comorbid gastroesophageal reflux disease (GERD) in the diabetic patient, discusses therapeutic options in care, and provides an approach to its evaluation and management. We searched for review articles published in the past 10 years through a PubMed sear...
journal_title：Journal of diabetes
pub_type： 杂志文章,评审
doi：10.1111/1753-0407.12279
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:In addition to its glucoregulatory actions, exendin-4, a stable glucagon-like peptide-1 receptor agonist, exhibits protective effects in the pancreas and anti-obesity effects. Suitable combination treatment with other anti-obesity or pancreas protective agents would be an effective approach to optimize these...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/j.1753-0407.2012.00227.x
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:Currently, there is no consensus regarding the medical treatment of chronic Charcot neuroarthropathy (CN) of foot, except for effective off-loading. Because tarsal bones are predominantly trabecular, teriparatide may improve the macroarchitecture of foot bones in chronic CN. METHODS:People with diabetes and...
journal_title：Journal of diabetes
pub_type： 杂志文章,随机对照试验
doi：10.1111/1753-0407.12902
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:In people with chronic kidney disease (CKD), HbA1c may be a problematic measure of glycemic control. Glycated albumin and fructosamine have been proposed as better markers of hyperglycemia in CKD. In the present study we investigated associations of HbA1c, glycated albumin, and fructosamine with fasting gluc...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/1753-0407.12618
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Liver X receptors (LXRs) including LXRα and LXRβ are members of the nuclear hormone receptor superfamily of ligand activated transcription factors, which serve as lipid sensors to regulate expression of genes controlling many aspects of cholesterol and fatty acid metabolism. The liver is the central organ in...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/1753-0407.12081
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:Considerable uncertainty remains about obstructive lung function( OLF) in adults with metabolic syndrome (MetS). The aim of the present study was to examine pulmonary function status in adults with and without MetS. METHODS:We used data from 3109 participants aged ≥20 years of the National Health and Nutrit...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/1753-0407.12136
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Glucagon-like peptide-1 (GLP-1) and its stable analogue exendin-4 maintain glucose homeostasis by modulating insulin secretion from pancreatic β-cells and controlling hepatic glucose output. Glucokinase (GK), by catalysing the first step in glycolysis, plays an important role in glucose-stimulated insulin se...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/j.1753-0407.2012.00193.x
更新日期：2012-12-01 00:00:00
abstract：:Highlights A large retrospective study indicates no association between GDM and most types of cancer; this is in contrast to a few smaller studies that have suggested an association with cancer. An increased risk of thyroid cancer in mothers with GDM was demonstrated. While this risk requires further investigation, it...
journal_title：Journal of diabetes
pub_type： 信件
doi：10.1111/1753-0407.12988
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Uncontrolled diabetes mellitus causes neuronal damage because of increased intracellular glucose. Natural products as complementary therapy may reduce neuronal complications. This study investigated whether fish oil (FO) and wheat germ oil (WGO) supplementation protects the brain in streptozotocin (STZ)-indu...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/1753-0407.12518
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Some reports suggest that concentrations of vitamin D are inversely, whereas concentrations of parathyroid hormone (PTH) are directly, associated with prevalent metabolic syndrome. Because of lingering uncertainty about these associations, we examined the cross-sectional associations between serum concentrat...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/j.1753-0407.2009.00046.x
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Atherosclerosis may be stimulated by the increased presence of insulin and tumor necrosis-factor-α (TNFα) with subsequent expression of vascular cell adhesion molecule-1 (VCAM-1). We hypothesized that extracellular signal-regulated kinase-5 (ERK5) plays an important role in insulin and TNFα-stimulated total ...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/1753-0407.12132
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:The aim of this study was to determine the effect of a new self-care guide package on gestational diabetes mellitus (GDM). METHODS:This randomized clinical trial was conducted on 152 women with GDM. The intervention group was provided with the self-care guide package and three face-to-face educational sessi...
journal_title：Journal of diabetes
pub_type： 杂志文章,随机对照试验
doi：10.1111/1753-0407.12827
更新日期：2019-02-01 00:00:00
abstract：:The 2011 United Nations political declaration against non-communicable diseases (NCDs) targeted four major risk factors: tobacco use, harmful use of alcohol, an unhealthy diet, and a lack of physical activity. The Framework Convention on Tobacco Control (FCTC), MPOWER strategies, and the four-stage model of the tobacc...
journal_title：Journal of diabetes
pub_type： 杂志文章,评审
doi：10.1111/1753-0407.12647
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:The association between dental caries and metabolic syndrome (MetS) is inconsistent. The aim of the present study was to assess the relationship between dental caries and MetS and its components in a middle-aged Chinese population. METHODS:A cross-sectional analysis was performed of 13 998 participants aged...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/1753-0407.12424
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Adipocyte fatty acid-binding protein (A-FABP) has been recognized as an important player in macrophage cholesterol trafficking and inflammation, and may promote the development of atherosclerosis. To further elucidate the role of A-FABP in atherosclerosis in diabetes, we investigated the relationship between...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/1753-0407.12549
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Glucagon-like peptide-1 (GLP-1) analogues have emerged as insulin secretagogues and are widely used in type 2 diabetic patients. GLP-1 analogues also demonstrate a promotion of beta cell proliferation and reduction of apoptosis in rodents. In the present study, we investigated the protection of pancreatic be...
journal_title：Journal of diabetes
pub_type： 杂志文章
doi：10.1111/1753-0407.12061
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Elevated blood or urinary concentrations of endocrine-disrupting chemicals (EDCs) may be related to increased risk of type 2 diabetes (T2D). The aim of the present study was to assess the role of EDCs in affecting risk of T2D and related metabolic traits. METHODS:MEDLINE was searched for cross-sectional and...
journal_title：Journal of diabetes
pub_type： 杂志文章,meta分析,评审
doi：10.1111/1753-0407.12325
更新日期：2016-07-01 00:00:00
abstract：:Following on from impressive economic development and urbanization, China is currently experiencing a high prevalence of metabolic syndrome. Patients with metabolic syndrome suffer from the "The Deadly Quartet" of hyperglycemia, hypertriglyceridemia, hypertension, and central (or upper body) obesity. Current treatment...
journal_title：Journal of diabetes
pub_type： 杂志文章,评审
doi：10.1111/j.1753-0407.2010.00090.x
更新日期：2010-12-01 00:00:00
abstract：:Crossover design has been widely used in late-phase clinical studies, as well as in pharmacokinetic and pharmacodynamic, bioequivalence, and medical device studies; however, its interpretability and applicability continue to be debated. Herein we provide discussions around a crossover design's scientific benefit, appl...
journal_title：Journal of diabetes
pub_type： 杂志文章,评审
doi：10.1111/1753-0407.12412
更新日期：2016-09-01 00:00:00
