Abstract:
BACKGROUND:It is clear that aerobic training (AT) can delay pancreatic exhaustion and slow the progression from prediabetes to type 2 diabetes (T2D), but there is little information regarding the effects of resistance training (RT) in people with prediabetes. This study compared the effectiveness of RT and AT in improving metabolic control and protecting β-cell function in people with prediabetes. METHODS:Chinese subjects (n = 248) with prediabetes were randomized to three groups: AT (n = 83), RT (n = 82) and control (n = 83). Subjects in the RT group performed 13 different resistance exercises per session using an elastic string. Those in the AT group performed aerobic exercises at 60%-70% of maximum heart rate. In both cases, exercises were performed three times per week for a period of 6 months. The primary outcome was improvement in metabolic control. Longitudinal changes between groups were tested using repeated-measures analysis of variance. RESULTS:Of the initial 248 participants, 217 finished the study, but all participants were included in the intention-to-treat analyses. There were no significant differences in demographic characteristics among the RT, AT, and control groups (P > 0.05). Changes in HbA1c were not significantly greater in RT than AT cohort (P = 0.059), but the decrease in HbA1c in both exercise groups was higher than in the control group (P < 0.05). CONCLUSIONS:In subjects with prediabetes, RT appears to improve metabolic control and preserve β-cell function comparable to AT. :目的: 已有研究表明有氧运动(aerobic training, AT)能够延迟胰岛衰竭并减慢从糖尿病前期到2型糖尿病(type 2 diabetes, T2D)的发展进程, 但是关于抗阻运动(resistance training, RT)对糖尿病前期人群的作用, 信息甚少。此研究比较了RT和AT在改善糖尿病前期人群代谢指标控制和保护胰岛β细胞功能方面的有效性。 方法: 选取符合纳入标准的糖尿病前期人群248例, 随机分为AT组83例, RT组82例, 对照组83例。RT组人群使用弹力绳每节进行13种不同动作的抗阻运动, AT组人群采用有氧操运动形式以达到最大心率的60%~70%。两组人群运动频率均为每周3次, 总计干预6个月。主要终点是代谢控制的改善, 组之间的纵向变化利用方差的重复度量分析。 结果: 248例初始患者中, 217例完成了最终研究, 数据统计分析时, 对全部248例研究对象进行了意向性分析。干预前三组的基线均衡可比, 尽管AT组与RT组间HbA1c的改善无统计学意义(P=0.059), 但与对照组相比, AT和RT均能有效改善HbA1c(P<0.05)。 结论: 针对糖尿病前期人群, RT能有效改善代谢指标控制和胰岛β细胞功能, 其效果与AT相当。.
journal_name
J Diabetesjournal_title
Journal of diabetesauthors
Yuan X,Dai X,Liu L,Hsue C,Miller JD,Fang Z,Li J,Feng J,Huang Y,Liu C,Shen J,Chen T,Liu Y,Mordes J,Lou Qdoi
10.1111/1753-0407.12955subject
Has Abstractpub_date
2020-01-01 00:00:00pages
25-37issue
1eissn
1753-0393issn
1753-0407journal_volume
12pub_type
杂志文章,多中心研究,随机对照试验abstract::Islet transplantation is an attractive concept for the treatment of Type 1 diabetes because of its potential high efficacy and minimal invasion to patients. The treatment may effectively control blood glucose for brittle Type 1 diabetes, resulting in a marked reduction in hypoglycemic episodes and improvements in HbA1...
journal_title:Journal of diabetes
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doi:10.1111/j.1753-0407.2009.00048.x
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abstract:BACKGROUND:A1c, a surrogate measure of glycemic control, is known to have a strong linear correlation with mean plasma glucose (MPG) when analyzed in populations of patients. However, clinically significant intersubject variability in this relationship exists, which suggests that A1c measurements may not reflect actual...
journal_title:Journal of diabetes
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doi:10.1111/j.1753-0407.2010.00066.x
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abstract:BACKGROUND:Uncontrolled diabetes mellitus causes neuronal damage because of increased intracellular glucose. Natural products as complementary therapy may reduce neuronal complications. This study investigated whether fish oil (FO) and wheat germ oil (WGO) supplementation protects the brain in streptozotocin (STZ)-indu...
journal_title:Journal of diabetes
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doi:10.1111/1753-0407.12518
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abstract:BACKGROUND:Cross-sectional studies have reported a close association between serum lipopolysaccharide-binding protein (LBP) and many metabolic disorders. However, no longitudinal study has explored the relationship between LBP and type 2 diabetes mellitus (T2DM). The aim of the present study was to investigate the asso...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12281
更新日期:2016-03-01 00:00:00
abstract::Glucagon-like peptide-1 (GLP-1) is the primary incretin hormone secreted from the intestine upon uptake of food to stimulate insulin secretion from pancreatic β-cells. GLP-1 exerts its effects by binding to its G-protein coupled receptors and subsequently activating adenylate cyclase, leading to generation of cyclic a...
journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/1753-0407.12161
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:The relationship among components of metabolic syndrome (MetS) and their association with diabetes is unclear in West Asia. The aim of the present study was to conduct factor analysis of MetS components and the effect these factors have on the incidence of type 2 diabetes (T2D) in a population-based cohort s...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12252
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:To address the prognostic value of combining tubular basement membrane (TBM) and glomerular basement membrane (GBM) thickness in diabetic nephropathy (DN). METHODS:This retrospective study enrolled 110 patients with type 2 diabetes and biopsy-proven DN from 2011 to 2018. The pathological findings were confi...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.13150
更新日期:2020-12-22 00:00:00
abstract:BACKGROUND:Limited information exists regarding the efficacy of pregabalin in Chinese patients with painful diabetic peripheral neuropathy (pDPN). METHODS:An 11-week double-blind placebo-controlled trial was performed in Chinese pDPN patients randomized (1 : 1) to 300 mg/day pregabalin or placebo. The primary outcome ...
journal_title:Journal of diabetes
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/1753-0407.12585
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Proprotein convertase subtilisin/kexin-type 9 (PCSK9) downregulates clearance of plasma cholesterol by liver. Its inactivation increases this clearance, reducing cardiovascular risk. However, a lack of PCSK9 could also lead to cholesterol accumulation in pancreatic islet beta cells, impairing insulin secreti...
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pub_type: 杂志文章
doi:10.1111/1753-0407.12139
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:To evaluate the association between thyroid autoimmunity and psychiatric disorders (depression, anxiety, eating disorder, schizophrenia or attention-deficit/hyperactivity disorder) among adolescents and young adults with type 1 diabetes (11-25 years). METHODS:We compared 9368 type 1 diabetes patients with t...
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doi:10.1111/1753-0407.13145
更新日期:2020-12-16 00:00:00
abstract:BACKGROUND:To analyze the glycemic response of Indian patients with type2 diabetes mellitus (T2DM) to combination therapy with vildagliptin and metformin and compare our data with those of clinical trials. METHODS:In a retrospective study of the hospital database, the glycemic control of 280 patients with T2DM who wer...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12078
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:In people with chronic kidney disease (CKD), HbA1c may be a problematic measure of glycemic control. Glycated albumin and fructosamine have been proposed as better markers of hyperglycemia in CKD. In the present study we investigated associations of HbA1c, glycated albumin, and fructosamine with fasting gluc...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12618
更新日期:2018-04-01 00:00:00
abstract::Diabetes mellitus is a metabolic disease with a considerable impact on healthcare owing to its increased prevalence and high mortality rate. Structural, morphological, and physiological changes in each of the ocular components have been described in detail. Autofluorescence has been described as a good indicator of me...
journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/1753-0407.12423
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus affects the systolic and diastolic function of the left ventricle (LV). The aim of the present study was to evaluate the index of myocardial performance (IMP), a new Doppler index, in asymptomatic, normotensive patients with type 2 diabetes mellitus (T2DM). METHODS:The study population con...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2008.00005.x
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to investigate whether the therapeutic efficacy of acarbose and metformin is correlated with baseline HbA1c levels in Chinese patients with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS:Data for 711 subjects were retrieved from the MARCH (Metformin and AcaRbose in...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12337
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:The aims of the present study were to examine the association of cigarette smoking and alcohol consumption with impaired β-cell function in Chinese men, particularly the interaction of smoking and alcohol consumption on impaired insulin secretion. METHODS:A population-based cross-sectional study was perform...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12314
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Glucose excursions and hypoglycemia are associated with cardiovascular complications. However, no studies have evaluated glucose excursions and the frequency of hypoglycemia in patients treated with mitiglinide/voglibose versus glimepiride as add-on to dipeptidyl peptidase-4 inhibitor therapy. METHODS:This ...
journal_title:Journal of diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/1753-0407.12658
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:With the current obesity epidemic, the search for effective weight loss approaches is required. In the present study, changes in weight, body composition and cardiovascular (CV) risk in response to a low-fat, reduced-energy diet (LFRE), a low-carbohydrate/high-protein diet (LCHP), or a commercially available...
journal_title:Journal of diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1753-0407.2009.00033.x
更新日期:2009-09-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12215
更新日期:2015-07-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12209
更新日期:2015-07-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12433
更新日期:2017-05-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/1753-0407.12412
更新日期:2016-09-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12961
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Mitogen-inducible gene 6 (Mig-6) has an important role in the regulation of cholesterol homeostasis and bile acid synthesis. However, the physiological functions of Mig-6 in the liver remain poorly understood. METHODS:To investigate Mig-6 functioning in the liver, we used conditionally ablated Mig-6 using t...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12261
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the effect of a new self-care guide package on gestational diabetes mellitus (GDM). METHODS:This randomized clinical trial was conducted on 152 women with GDM. The intervention group was provided with the self-care guide package and three face-to-face educational sessi...
journal_title:Journal of diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/1753-0407.12827
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Obesity and shorter telomeres increase the risk for diabetes complications and mortality. However, the relationship between obesity and telomere length in diverse Asian populations with type 2 diabetes (T2D) is not well understood. This study examined the association of baseline and changes in obesity indice...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12864
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Diabetes is a risk factor for various cancers, but its prognostic role in renal cell carcinoma (RCC) is controversial and understudied. This study investigated the prognostic value of type 2 diabetes (T2D) in RCC patients. METHODS:The clinicopathological and follow-up data of 451 RCC patients undergoing rad...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12957
更新日期:2019-12-01 00:00:00
abstract::Observations from clinical studies suggest that low serum levels of testosterone in men are often associated with obesity, insulin resistance, and metabolic compromise. Indeed, the clinical symptoms of late-onset hypogonadism are markedly similar to those of Type 2 diabetes mellitus (T2DM) and metabolic syndrome, and ...
journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/j.1753-0407.2010.00085.x
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Self-efficacy plays a critical role in diabetes self-care. Herein we explore factors contributing to decreased insulin therapy self-efficacy in insulin-naïve patients with type 2 diabetes mellitus (T2DM) initiating and managing insulin therapy over 36 weeks. METHODS:The study was conducted within an interna...
journal_title:Journal of diabetes
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/1753-0407.12037
更新日期:2013-09-01 00:00:00
abstract::Two years ago, data presented at the annual American Diabetes Association (ADA) meeting in New Orleans showed a marked decrease in deaths, especially those due to cardiovascular disease, with the use of empagliflozin. Two major questions have been asked: (i) was the result a fluke; and (ii) was it a class effect, or w...
journal_title:Journal of diabetes
pub_type: 社论
doi:10.1111/1753-0407.12583
更新日期:2017-11-01 00:00:00