Abstract:
:Glucagon-like peptide-1 (GLP-1) is the primary incretin hormone secreted from the intestine upon uptake of food to stimulate insulin secretion from pancreatic β-cells. GLP-1 exerts its effects by binding to its G-protein coupled receptors and subsequently activating adenylate cyclase, leading to generation of cyclic adenosine monophosphate (cAMP). cAMP stimulates insulin secretion via activation of its effectors PKA and Epac2 in pancreatic β-cells. In addition to its insulinotropic effects, GLP-1 also preserves pancreatic β-cell mass by stimulating β-cell proliferation. Unlike the action of sulphonylureas in lowering blood glucose levels, action of GLP-1 is affected by and interplays with glucose levels. Due to such advantages, GLP-1-based therapeutics have been rapidly developed and used clinically for treatment of type 2 diabetes. However, molecular mechanisms underlying how GLP-1 potentiates diminished glucose-stimulated insulin secretion and β-cell proliferation under diabetic conditions are not well understood. Here, we review the actions of GLP-1 in regulation of insulin secretion and pancreatic β-cell proliferation.
journal_name
J Diabetesjournal_title
Journal of diabetesauthors
Ma X,Guan Y,Hua Xdoi
10.1111/1753-0407.12161subject
Has Abstractpub_date
2014-09-01 00:00:00pages
394-402issue
5eissn
1753-0393issn
1753-0407journal_volume
6pub_type
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更新日期:2016-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-08-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/1753-0407.12294
更新日期:2016-03-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2020-01-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章,评审
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更新日期:2019-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-09-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12310
更新日期:2016-05-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12549
更新日期:2018-06-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2009.00046.x
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pub_type: 杂志文章
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journal_title:Journal of diabetes
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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更新日期:2009-09-01 00:00:00
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