当前位置： SCI文献检索 > Journal of Diabetes期刊下所有文献 > Lipopolysaccharide-binding protein cannot independently predict type 2 diabetes mellitus: A nested case-control study.

Lipopolysaccharide-binding protein cannot independently predict type 2 diabetes mellitus: A nested case-control study.

Abstract：

BACKGROUND:Cross-sectional studies have reported a close association between serum lipopolysaccharide-binding protein (LBP) and many metabolic disorders. However, no longitudinal study has explored the relationship between LBP and type 2 diabetes mellitus (T2DM). The aim of the present study was to investigate the association between serum LBP levels and the risk of developing T2DM. METHODS:A 5-year nested case-control study of 3510 individuals was performed as part of the Environment, Inflammation and Metabolic Diseases Study (EIMDS). Clinical data were collected at baseline. Serum levels of LBP and other biochemical factors, such as insulin and high-sensitivity C-reactive protein, were detected 5 years later. Subjects were diagnosed as having T2DM on the basis of results of an oral glucose tolerance test (OGTT) and 1998 World Health Organization criteria. Controls were randomly selected to match cases according to age, gender, and body mass index (BMI) in a 1:1 ratio. Odds ratios (OR) for T2DM were calculated using conditional logistic regression analysis. RESULTS:Over a 5-year follow-up period, 255 subjects developed T2DM. There was no significant difference in serum LBP levels between the T2DM and control groups at baseline (19.78 ± 6.40 versus 20.53 ± 6.99 μg/mL; P = 0.207). Subjects were divided into three groups based on tertiles of LBP concentrations (n = 170 in each group; T1 = 1.31-17.16 μg/mL LBP; T2 = 17.21-22.37 μg/mL LBP; T3 = 22.49-40.08 μg/mL LBP). There was no significant association between the risk of developing T2DM and any of the LBP tertiles in either a simple model or after adjusting for general status and biochemical factors. CONCLUSION:After matching for gender, age, and BMI, LBP does not improve prediction of the development of T2DM independently.

journal_name

J Diabetes

journal_title

Journal of diabetes

authors

Zhou H,Hu J,Zhu Q,Yang S,Zhang Y,Gao R,Liu L,Wang Y,Zhen Q,Lv Q,Li Q

doi

10.1111/1753-0407.12281

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

214-9

issue

eissn

1753-0393

issn

1753-0407

journal_volume

pub_type

杂志文章

在线工具

Lipopolysaccharide-binding protein cannot independently predict type 2 diabetes mellitus: A nested case-control study.