Factor analysis of metabolic syndrome components and predicting type 2 diabetes: Results of 10-year follow-up in a Middle Eastern population.


BACKGROUND:The relationship among components of metabolic syndrome (MetS) and their association with diabetes is unclear in West Asia. The aim of the present study was to conduct factor analysis of MetS components and the effect these factors have on the incidence of type 2 diabetes (T2D) in a population-based cohort study of the Tehran Lipid and Glucose Study (TLGS). METHODS:The present study enrolled 1861 men and 2706 women (20-60 years of age), from Tehran (Iran) who were free of diabetes at baseline and followed them for 10 years. A principal component analysis was performed to extract standardized factors from MetS components. Logistic regression was used to detect associations between the extracted factors and the incidence of diabetes. A propensity score was used to correct differential selection bias resulting from loss to follow-up. RESULTS:Factor analysis identified three factors (blood pressure, lipids and glycemia). Waist circumference was shared in three all factors. Blood pressure, lipids and glycemia were related to the incidence of diabetes with odds ratios (95% confidence intervals) of 2.23 (1.31-3.78), 1.89 (1.27-3.67), and 7.54 (4.09-13.91), respectively, in men and 2.13 (1.34-3.40), 2.06 (1.35-3.15), and 13.91 (7.29-26.51), respectively, in women for the third versus the first tertile of these standardized factors. CONCLUSIONS:Central adiposity may have a pivotal role in MetS linking other risk factors together. Glycemia had a high impact on the incidence of diabetes, whereas blood pressure and lipid had a similar moderate effect on the incidence of diabetes.


J Diabetes


Journal of diabetes


Ayubi E,Khalili D,Delpisheh A,Hadaegh F,Azizi F




Has Abstract


2015-11-01 00:00:00












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    abstract:BACKGROUND:Although diabetes is associated with ethnicity and worse cardiac surgery outcomes, no research has been done to study the effect of both diabetes and ethnicity on cardiac surgery outcomes in a multiethnic Southeast Asian cohort. Hence, this study aimed to delineate the association of ethnicity on outcomes af...

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    authors: Moorthy V,Liu W,Chan SP,Chew STH,Ti LK

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  • Association of characteristics of people with type 2 diabetes mellitus with discordant values of fasting glucose and HbA1c.

    abstract:BACKGROUND:Primary care physicians frequently encounter people with type 2 diabetes mellitus (T2DM) with discordant values for fasting glucose and HbA1c. The aim of this study was to identify the prevalence and characteristics of people in whom blood glucose and HbA1c did not match. METHODS:Overall, 64 553 people with...

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    pub_type: 杂志文章


    authors: Rathmann W,Bongaerts B,Kostev K

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  • Variable effects of gender and Western diet on lipid and glucose homeostasis in aged PCSK9-deficient C57BL/6 mice CSK9PC57BL/6.

    abstract:BACKGROUND:Proprotein convertase subtilisin/kexin-type 9 (PCSK9) downregulates clearance of plasma cholesterol by liver. Its inactivation increases this clearance, reducing cardiovascular risk. However, a lack of PCSK9 could also lead to cholesterol accumulation in pancreatic islet beta cells, impairing insulin secreti...

    journal_title:Journal of diabetes

    pub_type: 杂志文章


    authors: Mbikay M,Sirois F,Gyamera-Acheampong C,Wang GS,Rippstein P,Chen A,Mayne J,Scott FW,Chrétien M

    更新日期:2015-01-01 00:00:00

  • Endocrine-disrupting chemicals, risk of type 2 diabetes, and diabetes-related metabolic traits: A systematic review and meta-analysis.

    abstract:BACKGROUND:Elevated blood or urinary concentrations of endocrine-disrupting chemicals (EDCs) may be related to increased risk of type 2 diabetes (T2D). The aim of the present study was to assess the role of EDCs in affecting risk of T2D and related metabolic traits. METHODS:MEDLINE was searched for cross-sectional and...

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    authors: Song Y,Chou EL,Baecker A,You NC,Song Y,Sun Q,Liu S

    更新日期:2016-07-01 00:00:00

  • G protein-coupled receptor kinase-2: A potential biomarker for early diabetic cardiomyopathy.

    abstract:BACKGROUND:G protein-coupled receptor kinase-2 (GRK2) has been shown as a key regulator of cardiac function, and the myocardial GRK2 levels are mirrored by the levels in peripheral blood mononuclear cells (PBMCs). In this study, we evaluated the myocardial and PBMCs GRK2 levels in early diabetic cardiomyopathy (DCM). ...

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    pub_type: 杂志文章


    authors: Lai S,Fu X,Yang S,Zhang S,Lin Q,Zhang M,Chen H

    更新日期:2020-03-01 00:00:00

  • Role of oxidative stress-induced systemic and cavernosal molecular alterations in the progression of diabetic erectile dysfunction.

    abstract:BACKGROUND:Erectile dysfunction (ED) is a prevalent complication of diabetes, and oxidative stress is an important feature of diabetic ED. Oxidative stress-induced damage plays a pivotal role in the development of tissue alterations. However, the deleterious effects of oxidative stress in the corpus cavernosum with the...

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    pub_type: 杂志文章


    authors: Castela A,Gomes P,Domingues VF,Paíga P,Costa R,Vendeira P,Costa C

    更新日期:2015-05-01 00:00:00

  • Intensive walking exercise for lower extremity peripheral arterial disease: A systematic review and meta-analysis.

    abstract:BACKGROUND:Supervised treadmill exercise is the recommended therapy for peripheral arterial disease (PAD) patients with intermittent claudication (IC). However, most PAD patients do not exhibit typical symptoms of IC. The aim of the present study was to explore the efficacy and safety of intensive walking exercise in P...

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    authors: Lyu X,Li S,Peng S,Cai H,Liu G,Ran X

    更新日期:2016-05-01 00:00:00

  • Fish oil and wheat germ oil supplementation modulates brain injury in streptozotocin-induced diabetic rats.

    abstract:BACKGROUND:Uncontrolled diabetes mellitus causes neuronal damage because of increased intracellular glucose. Natural products as complementary therapy may reduce neuronal complications. This study investigated whether fish oil (FO) and wheat germ oil (WGO) supplementation protects the brain in streptozotocin (STZ)-indu...

    journal_title:Journal of diabetes

    pub_type: 杂志文章


    authors: Khedr NF

    更新日期:2017-11-01 00:00:00

  • Assessment of diabetes care and the healthcare system in economically and transport underdeveloped rural mountain areas of western China: A cross-sectional survey.

    abstract:BACKGROUND:The aim of the present study was to assess the quality of diabetes care and characteristics of the healthcare system in underdeveloped rural mountain areas of western China. METHODS:Questionnaires were used to collect data from 288 diabetic patients with a multistage cluster sampling method in Zhongjiang Co...

    journal_title:Journal of diabetes

    pub_type: 杂志文章


    authors: Ke L,Zhang Y,Wang X,Li S,Yang W,Tong N

    更新日期:2017-05-01 00:00:00

  • Relationship between CA 19-9 levels and glucose regulation in a middle-aged and elderly Chinese population.

    abstract:OBJECTIVE:To investigate carbohydrate antigen (CA) 19-9 levels in subjects with different glucose regulation status and assess the relationship between CA 19-9 and glucose regulation status in a Chinese population aged 40 years and older. METHODS:A total of 2792 participants aged 40 years or older with no history of d...

    journal_title:Journal of diabetes

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    authors: Huang Y,Xu Y,Bi Y,Xu M,Lu J,Wang T,Li M,Chen Y,Liu Y,Huang F,Xu B,Zhang J,Wang W,Ning G

    更新日期:2012-06-01 00:00:00

  • Serum adipocyte fatty acid-binding protein levels are associated with peripheral arterial disease in women, but not men, with type 2 diabetes mellitus.

    abstract:BACKGROUND:Adipocyte fatty acid-binding protein (A-FABP) has been recognized as an important player in macrophage cholesterol trafficking and inflammation, and may promote the development of atherosclerosis. To further elucidate the role of A-FABP in atherosclerosis in diabetes, we investigated the relationship between...

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    authors: Ding M,Shi JY,Xing YZ,Sun B,Fang QH,Zhang JY,Zhang QM,Chen LM,Yu DM,Li CJ

    更新日期:2018-06-01 00:00:00

  • Skin autofluorescence is increased in young people with type 1 diabetes exposed to secondhand smoking.

    abstract::Skin autofluorescence is increased in diabetes, rises with age, and predicts diabetes-related complications. Exposure to secondhand smoke, because one or more family members are smokers, further increases skin autofluorescence in children and young adults with type 1 diabetes. Elimination of passive smoking should be ...

    journal_title:Journal of diabetes

    pub_type: 信件


    authors: Vollenbrock CE,Van Waateringe RP,Veeze HJ,Aanstoot HJ,Wolffenbuttel BH

    更新日期:2017-03-01 00:00:00

  • Pre-existing type 2 diabetes is an adverse prognostic factor in patients with renal cell carcinoma.

    abstract:BACKGROUND:Diabetes is a risk factor for various cancers, but its prognostic role in renal cell carcinoma (RCC) is controversial and understudied. This study investigated the prognostic value of type 2 diabetes (T2D) in RCC patients. METHODS:The clinicopathological and follow-up data of 451 RCC patients undergoing rad...

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    authors: Yang H,Yin K,Wang Y,Xia M,Zhang R,Wang W,Chen J,Wang C,Shuang W

    更新日期:2019-12-01 00:00:00

  • Extracellular signal-regulated kinase-5: Novel mediator of insulin and tumor necrosis factor α-stimulated vascular cell adhesion molecule-1 expression in vascular cells.

    abstract:BACKGROUND:Atherosclerosis may be stimulated by the increased presence of insulin and tumor necrosis-factor-α (TNFα) with subsequent expression of vascular cell adhesion molecule-1 (VCAM-1). We hypothesized that extracellular signal-regulated kinase-5 (ERK5) plays an important role in insulin and TNFα-stimulated total ...

    journal_title:Journal of diabetes

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    authors: Mackesy DZ,Goalstone ML

    更新日期:2014-11-01 00:00:00

  • Diabetes mellitus prevalence is increasing in South Asians but is stable in Chinese living in Singapore and Mauritius.

    abstract:BACKGROUND:Asia is experiencing a type 2 diabetes epidemic, but prevalence differs by ethnicity and level of socioeconomic development. Singapore and Mauritius have implemented comprehensive campaigns to address this public health problem. We compared diabetes and obesity prevalence trends among Chinese and South Asian...

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    authors: Tan KHX,Barr ELM,Koshkina V,Ma S,Kowlessur S,Magliano DJ,Söderberg S,Chia KS,Zimmet P,Lim WY

    更新日期:2017-09-01 00:00:00

  • Performance of non-traditional hyperglycemia biomarkers by chronic kidney disease status in older adults with diabetes: Results from the Atherosclerosis Risk in Communities Study.

    abstract:BACKGROUND:In people with chronic kidney disease (CKD), HbA1c may be a problematic measure of glycemic control. Glycated albumin and fructosamine have been proposed as better markers of hyperglycemia in CKD. In the present study we investigated associations of HbA1c, glycated albumin, and fructosamine with fasting gluc...

    journal_title:Journal of diabetes

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    authors: Jung M,Warren B,Grams M,Kwong YD,Shafi T,Coresh J,Rebholz CM,Selvin E

    更新日期:2018-04-01 00:00:00

  • Role of prostaglandin D2 and the autonomic nervous system in niacin-induced flushing.

    abstract:BACKGROUND:Although niacin often has beneficial effects on the lipoprotein profile, flushing is an untoward effect associated with its use. Aspirin can only reduce the flushing response by 30-40%. Thus, the aim of the present study was to investigate the mechanisms of niacin-induced flushing, with and without aspirin, ...

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    authors: Parson HK,Harati H,Cooper D,Vinik AI

    更新日期:2013-03-01 00:00:00

  • Serum concentrations of vitamin D and parathyroid hormone and prevalent metabolic syndrome among adults in the United States.

    abstract:BACKGROUND:Some reports suggest that concentrations of vitamin D are inversely, whereas concentrations of parathyroid hormone (PTH) are directly, associated with prevalent metabolic syndrome. Because of lingering uncertainty about these associations, we examined the cross-sectional associations between serum concentrat...

    journal_title:Journal of diabetes

    pub_type: 杂志文章


    authors: Ford ES,Zhao G,Li C,Pearson WS

    更新日期:2009-12-01 00:00:00

  • Identification of new key genes for type 1 diabetes through construction and analysis of protein-protein interaction networks based on blood and pancreatic islet transcriptomes.

    abstract:BACKGROUND:Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic β-cells are destroyed by infiltrating immune cells. Bilateral cooperation of pancreatic β-cells and immune cells has been proposed in the progression of T1D, but as yet no systems study has investigated this possibility. The aims of the study...

    journal_title:Journal of diabetes

    pub_type: 杂志文章


    authors: Safari-Alighiarloo N,Taghizadeh M,Tabatabaei SM,Shahsavari S,Namaki S,Khodakarim S,Rezaei-Tavirani M

    更新日期:2017-08-01 00:00:00

  • Relationship between dental caries and metabolic syndrome among 13 998 middle-aged urban Chinese.

    abstract:BACKGROUND:The association between dental caries and metabolic syndrome (MetS) is inconsistent. The aim of the present study was to assess the relationship between dental caries and MetS and its components in a middle-aged Chinese population. METHODS:A cross-sectional analysis was performed of 13 998 participants aged...

    journal_title:Journal of diabetes

    pub_type: 杂志文章


    authors: Cao X,Wang D,Zhou J,Yuan H,Chen Z

    更新日期:2017-04-01 00:00:00

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    journal_title:Journal of diabetes

    pub_type: 社论


    authors: Drexler A

    更新日期:2017-11-01 00:00:00

  • Teriparatide (recombinant human parathyroid hormone [1-34]) increases foot bone remodeling in diabetic chronic Charcot neuroarthropathy: a randomized double-blind placebo-controlled study.

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    journal_title:Journal of diabetes

    pub_type: 杂志文章,随机对照试验


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    journal_title:Journal of diabetes

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    更新日期:2015-09-01 00:00:00

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    journal_title:Journal of diabetes

    pub_type: 杂志文章


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    更新日期:2016-01-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:Journal of diabetes

    pub_type: 杂志文章


    authors: Mansoor Q,Javaid A,Bilal N,Ismail M

    更新日期:2012-09-01 00:00:00

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    journal_title:Journal of diabetes

    pub_type: 杂志文章,评审


    authors: Jones TH

    更新日期:2010-09-01 00:00:00

  • A randomized clinical trial evaluating the safety and efficacy of sitagliptin added to the combination of sulfonylurea and metformin in patients with type 2 diabetes mellitus and inadequate glycemic control.

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    journal_title:Journal of diabetes

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Moses RG,Round E,Shentu Y,Golm GT,O'neill EA,Gantz I,Engel SS,Kaufman KD,Goldstein BJ

    更新日期:2016-09-01 00:00:00

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    journal_title:Journal of diabetes

    pub_type: 杂志文章


    authors: Shrom D,Sarwat S,Ilag L,Bloomgarden ZT

    更新日期:2010-06-01 00:00:00

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    pub_type: 杂志文章


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