Localisation of [3H] clonidine binding in rat neurohypophysis by means of electron-microscopic autoradiography.

Abstract:

:Electron-microscopic autoradiography of rat neurohypophyses treated with [3H] clonidine, an alpha 2-agonist, showed that binding apparently occurred preferentially at the neurosecretory endings and blood vessels rather than on the pituicytes. Since it is known that clonidine has a high affinity for plasma proteins, the distribution over the neurosecretory nerve endings would suggest the existence of presynaptic alpha 2-binding sites on neurosecretory neurones, which could indicate a regulatory function for catecholamines in neurohypophysial hormone release.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Livingston A,Morris B

doi

10.1007/BF00219223

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

467-9

issue

2

eissn

0302-766X

issn

1432-0878

journal_volume

244

pub_type

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