Abstract：
:Eosinophils are innate immune leukocytes found in relatively low numbers within the blood. Terminal effector functions of eosinophils, deriving from their capacity to release their content of tissue-destructive cationic proteins, have historically been considered primary effector mechanisms against specific parasites, and are likewise implicated in tissue damage accompanying allergic responses such as asthma. However, the past decade has seen dramatic advancements in the field of eosinophil immunobiology, revealing eosinophils to also be key participants in many other facets of innate immunity, from bridging innate and adaptive immune responses to orchestrating tissue remodeling events. Here, we review the multifaceted functions of eosinophils in innate immunity that are currently known, and discuss new avenues in this evolving story.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Shamri R,Xenakis JJ,Spencer LAdoi
10.1007/s00441-010-1049-6subject
Has Abstractpub_date
2011-01-01 00:00:00pages
57-83issue
1eissn
0302-766Xissn
1432-0878journal_volume
343pub_type
杂志文章,评审abstract：:The distribution and structure of the ureteric nerves in a small series of mammals was compared with that previously demonstrated in the rat. There was marked interspecies variation in the extent to which the nerves penetrated the wall of the ureter and in the degree of development of the deep submucous plexus. In ani...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00225768
更新日期：1975-07-23 00:00:00
abstract：:The processes involved in the regulation of bone cell metabolism are complex, including those implicated in bone cell coupling. This study was undertaken to develop a model that would permit real-time interaction between osteoclastic cells and osteoblasts in vitro. Osteogenic bone marrow stromal cells were isolated fr...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410051160
更新日期：1998-10-01 00:00:00
abstract：:Our immunocytochemical investigation of the magnocellular neuroendocrine system in the goldfish hypothalamus reveals enkephalin (ENK)-containing neurons interspersed among the vasotocin (VT)- and isotocin (IT)-containing neurons of the preoptic nucleus. The perikarya of the ENK, VT, and IT neurons do not show distinct...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00236894
更新日期：1979-08-03 00:00:00
abstract：:Expression of heat-shock protein 47 in intact and fibrotic liver and in hepatic constituent cells was investigated in mice. Immunohistochemical study of intact liver and Western blot analysis of the protein from isolated liver cells revealed that stellate cells and smooth muscle cells of interlobular vessels, but not ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050594
更新日期：1996-05-01 00:00:00
abstract：:The developmental mutant of Drosophila (oraJK84) is characterized by nonfunctional photoreceptor cells (R1-6), while the R7/R8 cells are normal. A fundamental question is: Does the near absence of photosensitive membranes inhibit development of the R1-6 axons and their synapses at the other end of the cell? The retina...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00238298
更新日期：1983-01-01 00:00:00
abstract：:Chemoreception in marine invertebrates mediates a variety of ecologically important behaviors including defense, reproduction, larval settlement and recruitment, and feeding. The sensory pathways that regulate deposit-feeding activity by polychaetes living in sedimentary habitats are of particular interest because suc...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-008-0660-2
更新日期：2008-09-01 00:00:00
abstract：:Recent studies have accomplished the establishment of a collagenous fiber-fringe matrix upon dental root surfaces in vitro. The present study was undertaken to follow the development of such a matrix in vitro and to test the possible effects of root surface treatments upon this matrix. Periodontal ligament cells, 0.1 ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00223152
更新日期：1989-10-01 00:00:00
abstract：:The so-called 'basement membrane' of arthropod compound eyes is known to be of heterogeneous origin (Odselius and Eloffson 1981). A major contribution in Diptera with open rhabdoms is provided by a pigmented component which lies at the basal end of the extracellular space of each ommatidium and fills it, the glial plu...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00222184
更新日期：1983-01-01 00:00:00
abstract：:Many efforts have been made to improve the diagnostic tools used to identify and to estimate the progress of ganglion cell and nerve fibre degeneration in glaucoma. Imaging by optical coherence tomography and measurements of the dimensions of the optic nerve head and the nerve fibre layer in central retinal areas is c...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-013-1602-1
更新日期：2013-08-01 00:00:00
abstract：:Spermatozoa from the cauda epididymidis of gossypol-treated rats exhibit distinctive departures from the morphology of spermatozoa from control rats: wrinkled and disorganized cell membrane in the head and tail regions, cell membrane missing from segments of the tail midpiece and principal piece regions, malformed hea...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00210003
更新日期：1981-01-01 00:00:00
abstract：:Calcitonin gene-related peptide (CGRP) was found extensively in the small intestine of both non-mammalian and mammalian vertebrates using radioimmunoassay and immunocytochemistry. By radioimmunoassay, the levels of CGRP in rats, mice, chickens, bullfrogs and rainbow trout were found to range from 91.5 to 419.1 ng/g ti...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00223142
更新日期：1989-10-01 00:00:00
abstract：:Electron microscopy of the rat lymph node disclosed reticular cells in close association with bundles of collagenous fibrils 30-45 nm in diameter, and electron lucent "amorphous" substances surrounded by microfibrils 11 nm in diameter, with junctional complexes. The amorphous substances, distinctly revealed by orcein ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00210522
更新日期：1981-01-01 00:00:00
abstract：:Research in mammals has established the existence of a neuronal network that lies within the hypothalamus and that regulates energy homeostasis. However, it is unknown whether this system has been evolutionarily conserved. The objective of the present study was therefore to examine the influence of the agouti-related ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-003-0755-8
更新日期：2003-08-01 00:00:00
abstract：:The present lectin histochemical comparison of cauda epididymal and ampullary bovine sperm was conducted to investigate whether ampullary secretions are involved in altering the plasma-membrane glycoconjugates of sperm. A marked redistribution of glycoconjugates between sperm from these two regions was indeed revealed...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00318822
更新日期：1994-03-01 00:00:00
abstract：:Teleost fish exhibit extraordinary cognitive skills that are comparable to those of mammals and birds. Kin recognition based on olfactory and visual imprinting requires neuronal circuits that were assumed to be necessarily dependent on the interaction of mammalian amygdala, hippocampus, and isocortex, the latter being...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-020-03378-4
更新日期：2021-01-30 00:00:00
abstract：:The uptake of macromolecules and larger energy-rich particles into the cell is known as phagocytosis. Phagocytosed material is enzymatically degraded in membrane-bound vesicles of the endosome/lysosome system (intracellular digestion). Whereas most, if not all, cells of the animal body are equipped with the molecular ...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-019-03096-6
更新日期：2019-09-01 00:00:00
abstract：:The cellular localization of the enzymes tyrosine hydroxylase (TH), aromatic amino-acid decarboxylase (or dopa decarboxylase, DDC), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the adrenal medulla of adult rats and rat fetuses (14th, 17th, 18th, 19th and 21st day) was examined. ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00236882
更新日期：1979-08-03 00:00:00
abstract：:Electron-dense granules (EDGs) are singular structures found in the tissues of several vertebrate and invertebrate organisms. Two types of EDGs were observed in hepatopancreatic cells of the crab Ucides cordatus: (1) a non-mineralized EDG, found mainly inside vacuoles, which reacted positively to acid phosphatase and ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-002-0646-4
更新日期：2003-01-01 00:00:00
abstract：:Recent studies demonstrated the expression of the insulin receptor (InsR) and its functional interaction with the transient receptor potential vanilloid type 1 receptor (TRPV1) in primary sensory neurons (PSNs). The present study was undertaken to reveal the target-specific expression of the InsR and its co-localizati...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-018-2868-0
更新日期：2018-11-01 00:00:00
abstract：:The lobula descending neuron (LDN) of dipterous insects is a unique nerve cell (one on each side of the brain) that projects directly from the lobula complex of the optic lobes to neuropil in thoracic ganglia. In the supraoesophageal ganglia the LDN has two prominent groups of branches of which at least one is dendrit...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218365
更新日期：1982-01-01 00:00:00
abstract：:Intracellular insulin-binding sites were directly traced in fixed monolayer cultures of a variety of cell types with the use of two fluorescent derivatives of insulin, viz. fluorescein isothiocyanate (FITC)-labelled and tetramethyl rhodamine isothiocyanate (TMRITC)-labelled insulin. Both derivatives retained the prope...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00232150
更新日期：1980-01-01 00:00:00
abstract：:Osmotic stimulation activates both estivated and inactivated specimens of Helix pomatia and increases their central arousal. High-pressure liquid chromatography has shown that, during activation, the level of both serotonin and dopamine decreases in the central nervous system (CNS) but increases in the foot and heart,...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0522-3
更新日期：2008-02-01 00:00:00
abstract：:Epidermal septate junctions of Nereis sp. and Cirriformia sp. fixed with OsO4 or glutaraldehyde/OsO4 display variable structure in electron micrographs. In transverse section the septa are often indistinct and obscured by opaque material that fills the junctional cleft. Septa (spaced at 180--280 A) are more clearly de...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00222150
更新日期：1976-10-22 00:00:00
abstract：:A histological examination of 205 fish representing four cyprinid species from a site 2.5 miles north of Wheeling, West Virginia, on the Ohio River revealed large (2--4 micron) cuboidal intranuclear inclusion bodies (NIB's) within neurons in the cranial and spinal ganglia of three species. Because the minnows had been...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00210112
更新日期：1981-01-01 00:00:00
abstract：:The ultrastructure of the calcium-sensitive (Ca-s) (PAS-positive) cells of the pars intermedia was investigated in eels kept in hypo- and hyperosmotic environments. Although the cells were moderately active in fresh water (FW), they were highly stimulated in deionized water (DW) and displayed an enlarged Golgi apparat...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00210015
更新日期：1981-01-01 00:00:00
abstract：:The effect of a physiological dose of vitamin C (100 microg/ml) on goat articular cartilage chondrocytes cultured in an alginate matrix and subjected to static pressurization of 2.4 MPa was investigated. Biochemical analyses of DNA, glycosaminoglycan (GAG), collagen and protease activity were carried out in various ma...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-008-0666-9
更新日期：2008-10-01 00:00:00
abstract：:The neurotensin-cell is identified immunohistochemically and ultrastructurally by differential counting of endocrine cells in the gut of a primate (Tupaia belangeri). Utilizing light microscopy, the EC-cells are identified by the Masson-Fontana silver stain; with the same method the neurotensin cells are not stained. ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00220968
更新日期：1977-11-23 00:00:00
abstract：:The pancreatic endocrine tissue of Fugu rubripes rubripes consists of numerous round principal islets (Brockmann bodies) of various sizes scattered around the gall-bladder. The endocrine cells are divided into A-, B-, D-, and Ff-cells. Each cell type was identified by comparing thick and thin sections in both light an...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00222157
更新日期：1976-10-29 00:00:00
abstract：:Iron loading of hepatocytes was followed through the stages (1-7) of metamorphosis in lamprey (Petromyzon marinus L.) using light- and electron-microscopic histochemistry. Iron is present in ferric and ferrous forms in the hepatocytes of larval lampreys in levels that can only be detected in the electron microscope. D...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00217405
更新日期：1983-01-01 00:00:00
abstract：:Periodontal regeneration requires the coordinated movement and differentiation of several cell types in order to re-establish the cementum, periodontal ligament (PDL), and alveolar bone. Cells in culture are often used as model systems for mature tissues, although they may represent expanded progenitor cell population...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-006-0282-5
更新日期：2007-01-01 00:00:00
