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Tumor necrosis factor-alpha regulates photoreceptor cell autophagy after retinal detachment.

Abstract：

:Photoreceptor cell death is the ultimate process underlying many retinal diseases, including retinal detachment (RD). Both autophagy and inflammatory factors, such as tumor necrosis factor-alpha (TNF-α), participate in photoreceptor cell death after RD. In this study, we examined whether TNF-α inhibition would impact the autophagy of photoreceptors and reduce the death of photoreceptors after retinal detachment (RD). RD models were created in C57BL/6J mice by a subretinal injection of 1% hyaluronic acid. The TNF-α inhibitor infliximab was administered via intraperitoneal injection two hours before RD. The levels of TNF-α and the autophagy-related proteins Atg5 and LC3B were assayed by immunofluorescence at 1 day, 3 days, and 7 days following RD. Apoptosis was examined at 3 days post-detachment via TUNEL assays. Photoreceptor cell counts were assessed at 7 days after RD. After RD, the protein levels of LC3B and Atg5 increased and reached a peak at 3 days, which decreased at 7 days. The expression of LC3B and Atg5 was prolonged and increased at a slower rate with TNF-α inhibition. The moderate augmentation and extension of autophagy through TNF-α inhibition resulted in the reduction of apoptosis and the enhancement of photoreceptor cell survival.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Xie J,Zhu R,Peng Y,Gao W,Du J,Zhao L,Chi Y,Yang L

doi

10.1038/s41598-017-17400-3

subject

Has Abstract

pub_date

2017-12-07 00:00:00

pages

17108

issue

1

issn

2045-2322

pii

10.1038/s41598-017-17400-3

journal_volume

7

pub_type

杂志文章

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