Genomic blueprints of sponge-prokaryote symbiosis are shared by low abundant and cultivatable Alphaproteobacteria.

abstract：:Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC...

journal_title：Scientific reports

authors： Rietschel L,Streit F,Zhu G,McAloney K,Frank J,Couvy-Duchesne B,Witt SH,Binz TM,CORtisolNETwork (CORNET) Consortium.,Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC).,McGrath J,Hickie IB,Hansell

更新日期：2017-11-10 00:00:00

abstract：:Known susceptibility loci together can only explain about 6-8% of the disease heritability of IgA nephropathy (IgAN), suggesting that there are still a large number of genetic variants remained to be discovered. We previously identified IgAN and systemic lupus erythematosus (SLE)/lupus nephritis (LN) shared many loci ...

journal_title：Scientific reports

authors： Zhou XJ,Nath SK,Qi YY,Sun C,Hou P,Zhang YM,Lv JC,Shi SF,Liu LJ,Chen R,Yang W,He KZ,Li Y,Zhang H

更新日期：2016-11-02 00:00:00

abstract：:DNA-stabilized silver clusters (Ag-DNA) show excellent promise as a multi-functional nanoagent for molecular investigations in living cells. The unique properties of these fluorescent nanomaterials allow for intracellular optical sensors with tunable cytotoxicity based on simple modifications of the DNA sequences. Thr...

journal_title：Scientific reports

authors： Bossert N,de Bruin D,Götz M,Bouwmeester D,Heinrich D

更新日期：2016-11-30 00:00:00

abstract：:Centrosomal protein 55 (CEP55) is a microtubule-bundling protein that participants in cell mitosis. It is overexpressed in several solid tumours and promotes the growth and invasion of cancer cells. However, the role of CEP55 in pancreatic cancer (PANC) remains unclear. Herein, upregulated expression of CEP55 (associa...

journal_title：Scientific reports

authors： Peng T,Zhou W,Guo F,Wu HS,Wang CY,Wang L,Yang ZY

更新日期：2017-07-19 00:00:00

abstract：:Kabuki Syndrome (KS) is a rare disorder characterized by distinctive facial features, short stature, skeletal abnormalities, and neurodevelopmental deficits. Previously, we showed that loss of function of RAP1A, a RAF1 regulator, can activate the RAS/MAPK pathway and cause KS, an observation recapitulated in other gen...

journal_title：Scientific reports

authors： Tsai IC,McKnight K,McKinstry SU,Maynard AT,Tan PL,Golzio C,White CT,Price DJ,Davis EE,Amrine-Madsen H,Katsanis N

更新日期：2018-07-17 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Nakagawa A,Naito AT,Sumida T,Nomura S,Shibamoto M,Higo T,Okada K,Sakai T,Hashimoto A,Kuramoto Y,Oka T,Lee JK,Harada M,Ueda K,Shiojima I,Limbourg FP,Adams RH,Noda T,Sakata Y,Akazawa H,Komuro I

更新日期：2018-10-29 00:00:00

abstract：:Previous experimental studies discovered universal growth of chains and nanowires of various chemical elements on a corrugated molecular network of Cu3N on the Cu(110). Herein, performing combined ab initio and quantum Hamiltonian studies we demonstrate that such chains can be used for a fast spin switching and entang...

journal_title：Scientific reports

authors： Sivkov IN,Bazhanov DI,Stepanyuk VS

更新日期：2017-06-05 00:00:00

abstract：:Greenhouse gas (GHG) emissions from livestock grazing systems are contributing to global warming. To examine the influence of yak grazing systems on GHG fluxes and relationships between GHG fluxes and environmental factors, we measured carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) fluxes over three key s...

journal_title：Scientific reports

authors： Liu Y,Yan C,Matthew C,Wood B,Hou F

更新日期：2017-01-20 00:00:00

abstract：:Metabolic syndrome (MS) and Framingham risk score (FRS) can be used for predicting the risk of developing cardiovascular diseases (CVD). Previous studies that compared FRS and MS have focused on high-income urban areas. This study focused on the comparison between FRS and MS when used in nomadic minorities in mountain...

journal_title：Scientific reports

authors： Yang W,Ma R,Zhang X,Guo H,He J,Mao L,Mu L,Hu Y,Yan Y,Liu J,Ma J,Li S,Ding Y,Zhang M,Zhang J,Guo S

更新日期：2018-11-07 00:00:00

abstract：:The major human pathogen Streptococcus pneumoniae is a leading cause of disease and death worldwide. Pneumococcal biofilm formation within the nasopharynx leads to long-term colonization and persistence within the host. We have previously demonstrated that the capsular surface-associated pneumococcal serine rich repea...

journal_title：Scientific reports

authors： Schulte T,Mikaelsson C,Beaussart A,Kikhney A,Deshmukh M,Wolniak S,Pathak A,Ebel C,Löfling J,Fogolari F,Henriques-Normark B,Dufrêne YF,Svergun D,Nygren PÅ,Achour A

更新日期：2016-09-01 00:00:00

abstract：:Biological hydrogen production is based on activity of specific enzymes called hydrogenases. Hydrogenases are oxygen sensitive metalloenzymes containing Ni and/or Fe atoms at the active site, catalyzing reversible reduction of protons. Generally, [Fe-Fe] hydrogenases prefer proton reduction to molecular hydrogen, a po...

journal_title：Scientific reports

authors： Mangayil R,Karp M,Lamminmäki U,Santala V

更新日期：2016-10-27 00:00:00

abstract：:A sensitive and selective chemiluminescence (CL) sensor based on the peroxidase-like activity of copper nanoclusters was established for the detection of cholesterol. Copper nanoclusters catalyse the CL reaction between luminol and H2O2. Because H2O2 is the oxidative product of cholesterol in the presence of cholester...

journal_title：Scientific reports

authors： Xu S,Wang Y,Zhou D,Kuang M,Fang D,Yang W,Wei S,Ma L

更新日期：2016-12-14 00:00:00

abstract：:One-carbon metabolism is essential for multiple cellular processes and can be assessed by the concentration of folate metabolites in the blood. One-carbon metabolites serve as methyl donors that are required for epigenetic regulation. Deficiencies in these metabolites are associated with a variety of poor health outco...

journal_title：Scientific reports

authors： Knight AK,Park HJ,Hausman DB,Fleming JM,Bland VL,Rosa G,Kennedy EM,Caudill MA,Malysheva O,Kauwell GPA,Sokolow A,Fisher S,Smith AK,Bailey LB

更新日期：2018-11-15 00:00:00

abstract：:Aiming to promote low-cost production of protein-rich forage rice and resource recycling from wastewater treatment plants, a pot experiment was conducted to assess the possibility to substitute mineral fertilizers with composted sewage sludge (CSS) with/without top-dressing with treated municipal wastewater (TWW). Res...

journal_title：Scientific reports

authors： Phung LD,Ichikawa M,Pham DV,Sasaki A,Watanabe T

更新日期：2020-06-23 00:00:00

abstract：:The eastern North American migratory population of monarch butterflies (Danaus plexippus) is in serious decline. Habitat restoration, including adding millions of host plants to compensate for loss of milkweed in US cropland, is a key part of the international conservation strategy to return this iconic butterfly to s...

journal_title：Scientific reports

authors： Baker AM,Potter DA

更新日期：2018-08-14 00:00:00

abstract：:The proteolytic system of Lactobacillus plays an essential role in bacterial growth, contributes to the flavor development of fermented products, and can release bioactive health-beneficial peptides during milk fermentation. In this work, a genomic analysis of all genes involved in the proteolytic system of L. delbrue...

journal_title：Scientific reports

authors： Brown L,Villegas JM,Elean M,Fadda S,Mozzi F,Saavedra L,Hebert EM

更新日期：2017-08-17 00:00:00

abstract：:The rapid increase in the number of genetically modified (GM) varieties has led to a demand for high-throughput methods to detect genetically modified organisms (GMOs). We describe a new dynamic array-based high throughput method to simultaneously detect 48 targets in 48 samples on a Fludigm system. The test targets i...

journal_title：Scientific reports

authors： Li X,Wu Y,Li J,Li Y,Long L,Li F,Wu G

更新日期：2015-01-05 00:00:00

abstract：:mRNAs containing premature termination codons (PTCs) are rapidly degraded through nonsense-mediated mRNA decay (NMD). However, some PTC-containing mRNAs evade NMD, and might generate mutant proteins responsible for various diseases, including cancers. Using PTC-containing human genomic β-globin constructs, we show tha...

journal_title：Scientific reports

authors： Kim WK,Yun S,Kwon Y,You KT,Shin N,Kim J,Kim H

更新日期：2017-11-20 00:00:00

abstract：:The prevention and control of peri-implantitis is a challenge in dental implant surgery. Dental implants with sustained antimicrobial coating are an ideal way of preventing peri-implantitis. This study reports development of a non- immunotoxicity multilayered coating on a titanium surface that had sustained antimicrob...

journal_title：Scientific reports

authors： Shi J,Liu Y,Wang Y,Zhang J,Zhao S,Yang G

更新日期：2015-11-09 00:00:00

abstract：:It has been demonstrated that development of three-dimensional printing technology has supported the researchers and surgeons to apply the bone tissue engineering to the oromandibular reconstruction. In this study, poly caprolactone/beta tricalcium phosphate (PCL/β-TCP) scaffolds were fabricated by multi-head depositi...

journal_title：Scientific reports

authors： Lee S,Choi D,Shim JH,Nam W

更新日期：2020-03-18 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies. The genomic landscape of the PDAC genome features four frequently mutated genes (KRAS, CDKN2A, TP53, and SMAD4) and dozens of candidate driver genes altered at low frequency, including potential clinical targets. Circulating cell-free...

journal_title：Scientific reports

authors： Takai E,Totoki Y,Nakamura H,Morizane C,Nara S,Hama N,Suzuki M,Furukawa E,Kato M,Hayashi H,Kohno T,Ueno H,Shimada K,Okusaka T,Nakagama H,Shibata T,Yachida S

更新日期：2015-12-16 00:00:00

abstract：:Tomato spotted wilt virus is a wide-spread plant disease in the world. It can threaten thousands of plants with a persistent and propagative manner. Early disease detection is expected to be able to control the disease spread, to facilitate management practice, and further to guarantee accompanying economic benefits. ...

journal_title：Scientific reports

authors： Wang D,Vinson R,Holmes M,Seibel G,Bechar A,Nof S,Tao Y

更新日期：2019-03-13 00:00:00

abstract：:Glioblastoma multiforme has a poor prognosis and is highly chemoresistant. In this study, we implanted biodegradable 1,3-bis[2-chloroethyl]-1-nitroso-urea-, irinotecan-, and cisplatin-eluting poly[(d,l)-lactide-co-glycolide] (BIC/PLGA) and virgin nanofibrous membranes on the brain surface of C6 glioma-bearing rats in ...

journal_title：Scientific reports

authors： Tseng YY,Huang YC,Yang TC,Yang ST,Liu SC,Chang TM,Kau YC,Liu SJ

更新日期：2016-07-29 00:00:00

abstract：:The formation of Pb, Zn, and Cu carboxylates (soaps) has caused visible deterioration in hundreds of oil paintings dating from the 15th century to the present. Through transport phenomena not yet understood, free fatty acids in the oil binding medium migrate through the paint and react with pigments containing heavy m...

journal_title：Scientific reports

authors： Chen-Wiegart YK,Catalano J,Williams GJ,Murphy A,Yao Y,Zumbulyadis N,Centeno SA,Dybowski C,Thieme J

更新日期：2017-09-14 00:00:00

abstract：:We set out to determine the usability of serum neurofilament light chain (sNfL), serum glial fibrillary acidic protein (sGFAP), and retinal parameters by using optical coherence tomography (OCT) as reliable biomarkers of the progression of oxaliplatin-induced peripheral neuropathy (OIPN). Forty-three patients schedule...

journal_title：Scientific reports

authors： Kim SH,Choi MK,Park NY,Hyun JW,Lee MY,Kim HJ,Jung SK,Cha Y

更新日期：2020-05-14 00:00:00

abstract：:Controlling thickness and tightness of surface passivation shells is crucial for many applications of core-shell nanoparticles (NP). Usually, to determine shell thickness, core and core/shell particle are measured individually requiring the availability of both nanoobjects. This is often not fulfilled for functional n...

journal_title：Scientific reports

authors： Weigert F,Müller A,Häusler I,Geißler D,Skroblin D,Krumrey M,Unger W,Radnik J,Resch-Genger U

更新日期：2020-11-26 00:00:00

abstract：:Ribociclib is a specific cyclin dependent kinase (Cdk) 4/6 inhibitor that induces G1 arrest by blocking the formation of cyclin D1-Cdk4/6 complex and inhibiting retinoblastoma (RB) phosphorylation. Cyclin D1 is overexpressed in over 90% of nasopharyngeal carcinoma (NPC) and CCND1 gene activation plays a critical role ...

journal_title：Scientific reports

authors： Wong CH,Ma BBY,Hui CWC,Lo KW,Hui EP,Chan ATC

更新日期：2018-05-22 00:00:00

abstract：:Hydrocarbons fuel our economy. Furthermore, intermediate goods and consumer products are often hydrocarbon-based. Beside all the progress they made possible, hydrogen-containing substances can have severe detrimental effects on materials exposed to them. Hydrogen-assisted failure of iron alloys has been recognised mor...

journal_title：Scientific reports

authors： Röhsler A,Sobol O,Hänninen H,Böllinghaus T

更新日期：2020-02-27 00:00:00

abstract：:CD134 (OX40) is a member of the tumour necrosis factor receptor superfamily (TNFRSF). It acts as a costimulatory receptor on T cells, but its role on NK cells is poorly understood. CD137, another TNFRSF member has been shown to enhance the anti-tumour activity of NK cells in various malignancies. Here, we examine the ...

journal_title：Scientific reports

authors： Turaj AH,Cox KL,Penfold CA,French RR,Mockridge CI,Willoughby JE,Tutt AL,Griffiths J,Johnson PWM,Glennie MJ,Levy R,Cragg MS,Lim SH

更新日期：2018-02-02 00:00:00

abstract：:Invasive pulmonary Aspergillosis is a leading cause of morbidity and mortality in immunosuppressed patients and treatment outcomes using oral antifungal triazoles remain suboptimal. Here we show that combining topical treatment using PC945, a novel inhaled triazole, with systemic treatment using known triazoles demons...

journal_title：Scientific reports

authors： Colley T,Sehra G,Daly L,Kimura G,Nakaoki T,Nishimoto Y,Kizawa Y,Strong P,Rapeport G,Ito K

更新日期：2019-07-01 00:00:00