An improved axillary staging system using the OSNA assay does not modify the therapeutic management of breast cancer patients.

abstract：:We report the synthesis of single-crystal iron germanium nanowires via chemical vapor deposition without the assistance of any catalysts. The assembly of single-crystal FeGe2 nanowires with tetragonal C16 crystal structure shows anisotropic magnetic behavior along the radial direction or the growth axial direction, wi...

journal_title：Scientific reports

authors： Tang S,Kravchenko I,Ward TZ,Zou Q,Yi J,Ma C,Chi M,Cao G,Li AP,Mandrus D,Gai Z

更新日期：2017-08-02 00:00:00

abstract：:Herbicide resistance has been observed in Chloris truncata, an Australian native C4 grass and a summer-fallow weed, which is common in no-till agriculture situations where herbicides are involved in crop management. To investigate the role of drought and increased atmospheric carbon dioxide (CO2) in determining weed g...

journal_title：Scientific reports

authors： Weller SL,Florentine SK,Mutti NK,Jha P,Chauhan BS

更新日期：2019-07-24 00:00:00

abstract：:Human phosphoglucomutase 1 (PGM1) is an evolutionary conserved enzyme that belongs to the ubiquitous and ancient α-D-phosphohexomutases, a large enzyme superfamily with members in all three domains of life. PGM1 catalyzes the bi-directional interconversion between α-D-glucose 1-phosphate (G1P) and α-D-glucose 6-phosph...

journal_title：Scientific reports

authors： Backe PH,Laerdahl JK,Kittelsen LS,Dalhus B,Mørkrid L,Bjørås M

更新日期：2020-03-27 00:00:00

abstract：:SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane activator Smoothened (Smo), have shown the rapid development of dru...

journal_title：Scientific reports

authors： Coni S,Mancuso AB,Di Magno L,Sdruscia G,Manni S,Serrao SM,Rotili D,Spiombi E,Bufalieri F,Petroni M,Kusio-Kobialka M,De Smaele E,Ferretti E,Capalbo C,Mai A,Niewiadomski P,Screpanti I,Di Marcotullio L,Canettieri G

更新日期：2017-03-09 00:00:00

abstract：:Efficient control of magnetism with electric means is a central issue of current spintronics research, which opens an opportunity to design integrated spintronic devices. However, recent well-studied methods are mostly based on electric-current injection, and they are inevitably accompanied by considerable energy loss...

journal_title：Scientific reports

authors： Takeuchi A,Mizushima S,Mochizuki M

更新日期：2019-07-02 00:00:00

abstract：:Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae, a well-known Chinese medicinal herb that presents anticancer effects in various types of cancer cell lines. In this study, we have successfully established zebrafish xenografts with 5 various human cancer cell lines; and validated these models with ant...

journal_title：Scientific reports

authors： Zhu XY,Guo DW,Lao QC,Xu YQ,Meng ZK,Xia B,Yang H,Li CQ,Li P

更新日期：2019-03-14 00:00:00

abstract：:After prolonged stay in an intensive care unit (ICU) patients often complain about cognitive impairments that affect health-related quality of life after discharge. The aim of this proof-of-concept study was to test the feasibility and effects of controlled visual and acoustic stimulation in a virtual reality (VR) set...

journal_title：Scientific reports

authors： Gerber SM,Jeitziner MM,Wyss P,Chesham A,Urwyler P,Müri RM,Jakob SM,Nef T

更新日期：2017-10-16 00:00:00

abstract：:Cisplatin, a highly effective and widely used chemotherapeutic agent, has a major limitation for its nephrotoxicity. We recently identified a novel strategy for attenuating its nephrotoxicity in chemotherapy by an effective adjuvant via epigenetic modification through targeting HDAC2. Molecular docking and SPR assay f...

journal_title：Scientific reports

authors： Ma T,Huang C,Meng X,Li X,Zhang Y,Ji S,Li J,Ye M,Liang H

更新日期：2016-05-05 00:00:00

abstract：:Nanostructure arrays such as nanowire, nanopillar, and nanocone arrays have been proposed to be promising antireflection structures for photovoltaic applications due to their great light trapping ability. In this paper, the optical properties of Si nanopillar and nanocone arrays in visible and infrared region were stu...

journal_title：Scientific reports

authors： Wang ZY,Zhang RJ,Wang SY,Lu M,Chen X,Zheng YX,Chen LY,Ye Z,Wang CZ,Ho KM

更新日期：2015-01-15 00:00:00

abstract：:In this study, real-time and in-situ permittivity measurements under intense microwave electromagnetic fields are proposed as a powerful technique for the study of microwave-enhanced thermal processes in materials. In order to draw reliable conclusions about the temperatures at which transformations occur, we address ...

journal_title：Scientific reports

authors： García-Baños B,Reinosa JJ,Peñaranda-Foix FL,Fernández JF,Catalá-Civera JM

更新日期：2019-07-25 00:00:00

abstract：:The therapeutic potential of nonthermal plasma for cancer treatment has been reported recently. The heterogeneity of cancer cells need to be addressed to design effective anticancer treatments. Here, we show that treatment with nonthermal atmospheric-pressure plasma dissolved in a liquid (liquid plasma) induces oxidat...

journal_title：Scientific reports

authors： Nguyen NH,Park HJ,Yang SS,Choi KS,Lee JS

更新日期：2016-07-01 00:00:00

abstract：:Available CFTR modulators provide no therapeutic benefit for cystic fibrosis (CF) caused by many loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, including N1303K. We previously introduced the concept of 'co-potentiators' (combination-potentiators) to rescu...

journal_title：Scientific reports

authors： Phuan PW,Tan JA,Rivera AA,Zlock L,Nielson DW,Finkbeiner WE,Haggie PM,Verkman AS

更新日期：2019-11-27 00:00:00

abstract：:APOBEC3 family members are cytidine deaminases with roles in intrinsic responses to infection by retroviruses and retrotransposons, and in the control of other DNA viruses, such as herpesviruses, parvoviruses and hepatitis B virus. Although effects of APOBEC3 members on viral DNA have been demonstrated, it is not know...

journal_title：Scientific reports

authors： Milewska A,Kindler E,Vkovski P,Zeglen S,Ochman M,Thiel V,Rajfur Z,Pyrc K

更新日期：2018-04-13 00:00:00

abstract：:Understanding and manipulating the dynamic properties of the magnetic vortices stabilized in patterned ferromagnetic structures are of great interest owing to the superior resonant features with the high thermal stability and their flexible tunability. So far, numerous methods for investigating the dynamic properties ...

journal_title：Scientific reports

authors： Cui X,Hu S,Hidegara M,Yakata S,Kimura T

更新日期：2015-12-09 00:00:00

abstract：:The total spatial coverage of Marine Protected Areas (MPAs) within the Brazilian Economic Exclusive Zone (EEZ) has recently achieved the quantitative requirement of the Aichii Biodiversity Target 11. However, the distribution of MPAs in the Brazilian EEZ is still unbalanced regarding the proportion of protected ecosys...

journal_title：Scientific reports

authors： Endo CAK,Gherardi DFM,Pezzi LP,Lima LN

更新日期：2019-06-14 00:00:00

abstract：:Sigma-1 and sigma-2 receptors are emerging therapeutic targets. We have identified that simple ammonium salts bind to these receptors and are effective in vivo. Radioligand binding assays were used to obtain structure-activity relationships of these salts. MTS assays were performed to determine their effect on growth ...

journal_title：Scientific reports

authors： Brimson JM,Akula KK,Abbas H,Ferry DR,Kulkarni SK,Russell ST,Tisdale MJ,Tencomnao T,Safrany ST

更新日期：2020-06-08 00:00:00

abstract：:We demonstrated tailored plasmon-induced transparency (PIT) in a metal (Au)-insulator (SiO2)-metal (Ag) (MIM) structure, where the Fano interference between the MIM waveguide mode and the surface plasmon polariton (SPP) resonance mode induced a transparency window in an otherwise opaque wavenumber (k) region. A series...

journal_title：Scientific reports

authors： Matsunaga K,Hirai Y,Neo Y,Matsumoto T,Tomita M

更新日期：2017-12-19 00:00:00

abstract：:The aim of the present study was to evaluate sleep and mood disorders in patients with irritating ocular diseases. The study design was a cross-sectional/case-control study conducted in six eye clinics. Out of 715 outpatients diagnosed with irritating ocular surface diseases and initially enrolled, 301 patients with d...

journal_title：Scientific reports

authors： Ayaki M,Kawashima M,Negishi K,Kishimoto T,Mimura M,Tsubota K

更新日期：2016-03-01 00:00:00

abstract：:HIV maturation inhibitors are an emerging class of anti-retroviral compounds that inhibit the viral protease-mediated cleavage of the Gag, CA-SP1 (capsid-spacer peptide 1) peptide to mature CA. The first-in-class maturation inhibitor bevirimat (BVM) displayed potent activity against HIV-1 clade B but was ineffective a...

journal_title：Scientific reports

authors： Ghimire D,Timilsina U,Srivastava TP,Gaur R

更新日期：2017-03-02 00:00:00

abstract：:Surface ocean bubble-bursting generates aerosols composed of microscopic salt-water droplets, enriched in marine organic matter. The organic fraction profoundly influences aerosols' properties, by scattering solar radiations and nucleating water particles. Still little is known on the biochemical and microbiological c...

journal_title：Scientific reports

authors： Rastelli E,Corinaldesi C,Dell'Anno A,Lo Martire M,Greco S,Cristina Facchini M,Rinaldi M,O'Dowd C,Ceburnis D,Danovaro R

更新日期：2017-09-13 00:00:00

abstract：:Higher and lower levels of alertness typically lead to a leftward and rightward bias in attention, respectively. This relationship between alertness and spatial attention potentially has major implications for health and safety. The current study examined alertness and spatial attention under simulated shiftworking co...

journal_title：Scientific reports

authors： Chandrakumar D,Dorrian J,Banks S,Keage HAD,Coussens S,Gupta C,Centofanti SA,Stepien JM,Loetscher T

更新日期：2020-09-11 00:00:00

abstract：:We analyze a transition from single peaked to bimodal velocity distribution in a relativistic fluid under increasing temperature, in contrast with a non-relativistic gas, where only a monotonic broadening of the bell-shaped distribution is observed. Such transition results from the interplay between the raise in therm...

journal_title：Scientific reports

authors： Mendoza M,Araújo NA,Succi S,Herrmann HJ

更新日期：2012-01-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a tinnitus treatment option. Promising results have been obtained by consecutive stimulation of lateral frontal and auditory brain regions. We investigated a combined stimulation paradigm targeting the anterior cingulate cortex (ACC) with double ...

journal_title：Scientific reports

authors： Kreuzer PM,Lehner A,Schlee W,Vielsmeier V,Schecklmann M,Poeppl TB,Landgrebe M,Rupprecht R,Langguth B

更新日期：2015-12-15 00:00:00

abstract：:Previous studies reported that boreal winter precipitation in southeastern China (SEC) tends to increase during El Niño. In this study, however, we find that most weak El Niño events are accompanied by below-normal precipitation in SEC, although strong El Niño events are accompanied by above-normal precipitation in SE...

journal_title：Scientific reports

authors： Ke Z,Jiang X,Wang Z

更新日期：2019-11-22 00:00:00

abstract：:miR1444s are functionally significant miRNAs targeting polyphenol oxidase (PPO) genes for cleavage. MIR1444 genes were reported only in Populus trichocarpa. Through the computational analysis of 215 RNA-seq data, four whole genome sequences of Salicaceae species and deep sequencing of six P. trichocarpa small RNA libr...

journal_title：Scientific reports

authors： Wang M,Li C,Lu S

更新日期：2017-01-10 00:00:00

abstract：:We demonstrate a comprehensive quantitative analysis of vector beam states (VBSs) by using a vector field reconstruction (VFR) technique integrating interferometry and imaging polarimetry, where the analysis is given by a cylindrically polarized Laguerre-Gaussian (LG) mode expansion of VBSs. From test examples of cyli...

journal_title：Scientific reports

authors： Suzuki M,Yamane K,Oka K,Toda Y,Morita R

更新日期：2019-07-10 00:00:00

abstract：:Aminoacyl-tRNA synthetases are the key enzymes for protein synthesis. Glycine, alanine, serine and tyrosine are the major amino acids composing fibroin of silkworm. Among them, the genes of alanyl-tRNA synthetase (AlaRS) and glycyl-tRNA synthetase (GlyRS) have been cloned. In this study, the seryl-tRNA synthetase (Ser...

journal_title：Scientific reports

authors： Hu J,Tian J,Li F,Xue B,Hu J,Cheng X,Li J,Shen W,Li B

更新日期：2017-01-30 00:00:00

abstract：:The auditory steady-state response (ASSR) has been used to detect auditory processing deficits in patients with psychiatric disorders. However, the methodology of ASSR recording from the brain surface has not been standardized in preclinical studies, limiting its use as a translational biomarker. The sites of maximal ...

journal_title：Scientific reports

authors： Kozono N,Honda S,Tada M,Kirihara K,Zhao Z,Jinde S,Uka T,Yamada H,Matsumoto M,Kasai K,Mihara T

更新日期：2019-06-11 00:00:00

abstract：:Electron ptychography has seen a recent surge of interest for phase sensitive imaging at atomic or near-atomic resolution. However, applications are so far mainly limited to radiation-hard samples, because the required doses are too high for imaging biological samples at high resolution. We propose the use of non-conv...

journal_title：Scientific reports

authors： Pelz PM,Qiu WX,Bücker R,Kassier G,Miller RJD

更新日期：2017-08-29 00:00:00

abstract：:Histamine is an important neurotransmitter that contributes to various processes, including the sleep-wake cycle, learning, memory, and stress responses. Its actions are mediated through histamine H1-H4 receptors. Gene knockout and pharmacological studies have revealed the importance of H1 receptors in learning and me...

journal_title：Scientific reports

authors： Kárpáti A,Yoshikawa T,Naganuma F,Matsuzawa T,Kitano H,Yamada Y,Yokoyama M,Futatsugi A,Mikoshiba K,Yanai K

更新日期：2019-11-11 00:00:00