Phenothiazine derivative-accelerated microbial extracellular electron transfer in bioelectrochemical system.

abstract：:Fibroblast growth factor-21 (FGF21) is closely related to various metabolic and cardiovascular disorders. However, the direct targets and mechanisms linking FGF21 to blood pressure control and hypertension are still elusive. Here we demonstrated a novel regulatory function of FGF21 in the baroreflex afferent pathway (...

journal_title：Scientific reports

authors： He JL,Zhao M,Xia JJ,Guan J,Liu Y,Wang LQ,Song DX,Qu MY,Zuo M,Wen X,Yu X,Huo R,Pan ZW,Ban T,Zhang Y,Zhu JX,Shou W,Qiao GF,Li BY

更新日期：2016-07-08 00:00:00

abstract：:In this paper, we demonstrate a novel dual-pump approach to generate robust optical frequency comb with varying free spectral range (FSR) spacing in a CMOS-compatible high-Q micro-ring resonator (MRR). The frequency spacing of the comb can be tuned by an integer number FSR of the MRR freely in our dual-pump scheme. Th...

journal_title：Scientific reports

authors： Wang W,Chu ST,Little BE,Pasquazi A,Wang Y,Wang L,Zhang W,Wang L,Hu X,Wang G,Hu H,Su Y,Li F,Liu Y,Zhao W

更新日期：2016-06-24 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a major global health burden. Functional exhaustion and numerical reduction of HBV-specific cytotoxic T lymphocytes (CTLs) in the liver and peripheral blood limit anti-HBV CTL activity in patients with chronic HBV infection (CHB). However, the ongoing anti-HBV CD8(+) T cell...

journal_title：Scientific reports

authors： Wang Y,Zhang Z,Ji D,Chen GF,Feng X,Gong LL,Guo J,Li ZW,Chen CF,Zhao BB,Li ZG,Li QJ,Yan HP,Sempowski G,Wang FS,He YW

更新日期：2015-07-22 00:00:00

abstract：:Sublingual immunization is emerging as an alternative to nasal immunization and induction of mucosal IgA responses. Using Bacillus anthracis edema toxin (EdTx) as an adjuvant, we previously showed that innate responses triggered after sublingual immunization could limit generation of IgA responses. We tested whether c...

journal_title：Scientific reports

authors： Rowe JC,Attia Z,Kim E,Cormet-Boyaka E,Boyaka PN

更新日期：2019-01-24 00:00:00

abstract：:Results from epidemiological and prospective studies indicate a close association between periodontitis and diabetes. However the mechanisms by which periodontal pathogens influence the development of prediabetes/diabetes are not clear. We previously reported that oral administration of a periodontal pathogen, Porphyr...

journal_title：Scientific reports

authors： Ilievski V,Toth PT,Valyi-Nagy K,Valyi-Nagy T,Green SJ,Marattil RS,Aljewari HW,Wicksteed B,O'Brien-Simpson NM,Reynolds EC,Layden BT,Unterman TG,Watanabe K

更新日期：2020-06-19 00:00:00

abstract：:A new fluorine-substituted ligand, compound 1 (CB251), with a very high affinity (Ki = 0.27 ± 0.09 nM) and selectivity for the 18-kDa translocator protein (TSPO), is presented as an attractive biomarker for the diagnosis of neuroinflammation, neurodegeneration and tumour progression. To test compound 1 as a TSPO PET i...

journal_title：Scientific reports

authors： Perrone M,Moon BS,Park HS,Laquintana V,Jung JH,Cutrignelli A,Lopedota A,Franco M,Kim SE,Lee BC,Denora N

更新日期：2016-02-08 00:00:00

abstract：:Protoporphyrin IX (PpIX) induced by 5-aminolevulinic acid (5-ALA) is increasingly used as a fluorescent marker for fluorescence-guided resection of malignant gliomas. Understanding how the properties of the excitation light source and PpIX fluorescence interact with the surgical microscope is critical for effective us...

journal_title：Scientific reports

authors： Belykh E,Miller EJ,Patel AA,Bozkurt B,Yağmurlu K,Robinson TR,Nakaji P,Spetzler RF,Lawton MT,Nelson LY,Seibel EJ,Preul MC

更新日期：2018-08-22 00:00:00

abstract：:The aim of the study was to investigate the role of endogenous sulfur dioxide (SO2)/ aspartate aminotransferase 1 (AAT1) pathway in stretch-induced excessive collagen expression and its mechanism. The mechanical stretch downregulated SO2/AAT1 pathway and increased collagen I and III protein expression. Importantly, AA...

journal_title：Scientific reports

authors： Liu J,Yu W,Liu Y,Chen S,Huang Y,Li X,Liu C,Zhang Y,Li Z,Du J,Tang C,Du J,Jin H

更新日期：2016-02-16 00:00:00

abstract：:The interpenetrating morphology formed by the electron donor and acceptor materials is critical for the performance of polymer:fullerene bulk heterojunction (BHJ) photovoltaic (PV) cells. In this work we carried out a systematic investigation on a high PV efficiency (>6%) BHJ system consisting of a newly developed 5,6...

journal_title：Scientific reports

authors： Xiao T,Xu H,Grancini G,Mai J,Petrozza A,Jeng US,Wang Y,Xin X,Lu Y,Choon NS,Xiao H,Ong BS,Lu X,Zhao N

更新日期：2014-06-09 00:00:00

abstract：:The controlled preparation of Au nanoparticles (NPs) in the size range of 6 to 22 nm is explored in this study. The Au NPs were prepared by the reduction of tetrachloroauric acid using maltose in the presence of nonionic surfactant Tween 80 at various concentrations to control the size of the resulting Au NPs. With in...

journal_title：Scientific reports

authors： Suchomel P,Kvitek L,Prucek R,Panacek A,Halder A,Vajda S,Zboril R

更新日期：2018-03-15 00:00:00

abstract：:Fatty alcohols have been identified as promising organic phase change materials (PCMs) for thermal energy storage, because of their suitable temperature range, nontoxicity and can be obtained from both natural and synthetic sources. Like all other organic PCMs, octadecanol (OD) as PCM suffers from low thermal conducti...

journal_title：Scientific reports

authors： Al-Ahmed A,Sarı A,Mazumder MAJ,Hekimoğlu G,Al-Sulaiman FA,Inamuddin

更新日期：2020-06-08 00:00:00

abstract：:Anserine/carnosine supplementation improves cerebral blood flow and verbal episodic memory in elderly people, as we previously reported. Anserine's buffering activity is superior to that of carnosine at neutral pH. In human sera, carnosine but not anserine is rapidly cleaved by carnosinase, limiting its effectiveness....

journal_title：Scientific reports

authors： Kaneko J,Enya A,Enomoto K,Ding Q,Hisatsune T

更新日期：2017-10-03 00:00:00

abstract：:Understanding the complex dynamics of cardio-respiratory coupling sheds light on the underlying mechanisms governing the communication between these two physiological systems. Previous research has predominantly considered the coupling at respiratory rates slower than the heart rate and shown that respiratory oscillat...

journal_title：Scientific reports

authors： Perry S,Khovanova NA,Khovanov IA

更新日期：2019-02-07 00:00:00

abstract：:Most everyday surfaces are randomly rough and self-similar on sufficiently small scales. We investigated the tactile perception of randomly rough surfaces using 3D-printed samples, where the topographic structure and the statistical properties of scale-dependent roughness were varied independently. We found that the t...

journal_title：Scientific reports

authors： Sahli R,Prot A,Wang A,Müser MH,Piovarči M,Didyk P,Bennewitz R

更新日期：2020-09-25 00:00:00

abstract：:During the last decades, atmospheric nitrogen loading in mountain ranges of the Northern Hemisphere has increased substantially, resulting in high nitrate concentrations in many lakes. Yet, how increased nitrogen has affected denitrification, a key process for nitrogen removal, is poorly understood. We measured actual...

journal_title：Scientific reports

authors： Palacin-Lizarbe C,Camarero L,Hallin S,Jones CM,Catalan J

更新日期：2020-02-20 00:00:00

abstract：:The secreted Ly-6/uPAR Related Protein-1 (SLURP1) is an immunomodulatory protein that promotes corneal immune- and angiogenic-privilege. Here, we have examined the influence of SLURP1 on neutrophil-vascular endothelial cell interactions using human umbilical vein endothelial cells (HUVEC) and differentiated neutrophil...

journal_title：Scientific reports

authors： Swamynathan S,Tiwari A,Loughner CL,Gnalian J,Alexander N,Jhanji V,Swamynathan SK

更新日期：2019-04-11 00:00:00

abstract：:Transcription activator-like effector (TALE) nuclease (TALEN) is a site-specific nuclease, which can be freely designed and easily constructed. Numerous methods of constructing TALENs harboring different TALE scaffolds and repeat variants have recently been reported. However, the functionalities of structurally differ...

journal_title：Scientific reports

authors： Sakuma T,Ochiai H,Kaneko T,Mashimo T,Tokumasu D,Sakane Y,Suzuki K,Miyamoto T,Sakamoto N,Matsuura S,Yamamoto T

更新日期：2013-11-29 00:00:00

abstract：:Thrombocytopenia is common in patients with dengue virus (DENV) infections. With a focus on understanding the possible mechanism of thrombocytopenia in DENV infections we described a direct correlation between activation and depletion of platelets in patients. Our data showed a sharp decrease in platelet counts at day...

journal_title：Scientific reports

authors： Ojha A,Nandi D,Batra H,Singhal R,Annarapu GK,Bhattacharyya S,Seth T,Dar L,Medigeshi GR,Vrati S,Vikram NK,Guchhait P

更新日期：2017-01-31 00:00:00

abstract：:The liver is constantly exposed to dietary antigens, viruses, and bacterial products with inflammatory potential. For decades cellular uptake of virus has been studied in connection with infection, while the few studies designed to look into clearance mechanisms focused mainly on the role of macrophages. In recent yea...

journal_title：Scientific reports

authors： Øie CI,Wolfson DL,Yasunori T,Dumitriu G,Sørensen KK,McCourt PA,Ahluwalia BS,Smedsrød B

更新日期：2020-01-21 00:00:00

abstract：:Busulfan (Bu) is an alkylating agent commonly used in preparative regimens for hematologic malignant and non-malignant patients undergoing hematopoietic stem cell transplantation (HSCT). The objective of the present study was to develop an UPLC-MS/MS method for quantification of Bu in human plasma. A total of 55 patie...

journal_title：Scientific reports

authors： Matar KM,Alshemmari SH,Refaat S,Anwar A

更新日期：2020-06-02 00:00:00

abstract：:Membrane type 1 metalloproteinase (MT1-MMP) is an important regulator of cancer invasion, growth and angiogenesis, thus making it an attractive target for cancer imaging and therapy. A non-substrate peptide (MT1-AF7p) that bonded to the "MT-Loop" region of MT1-MMP was identified by using a phage-displayed peptide libr...

journal_title：Scientific reports

authors： Ren L,Wang Y,Zhu L,Shen L,Zhang J,Wang J,Li H,Zheng Q,Yu D,Fang X

更新日期：2018-07-09 00:00:00

abstract：:Alzheimer's disease (AD) is a circadian clock-related disease. However, it is not very clear whether pre-symptomatic AD leads to circadian disruption or whether malfunction of circadian rhythms exerts influence on development of AD. Here, we report a functional clock that exists in the hippocampus. This oscillator bot...

journal_title：Scientific reports

authors： Ma Z,Jiang W,Zhang EE

更新日期：2016-10-31 00:00:00

abstract：:Sex hormones may have a role in the pathophysiology of substance use disorders, as demonstrated by the association between testosterone and addictive behaviour in opioid dependence. Although opioid use has been found to suppress testosterone levels in men and women, the extent of this effect and how it relates to meth...

journal_title：Scientific reports

authors： Bawor M,Dennis BB,Samaan MC,Plater C,Worster A,Varenbut M,Daiter J,Marsh DC,Desai D,Steiner M,Anglin R,Coote M,Pare G,Thabane L,Samaan Z

更新日期：2014-08-26 00:00:00

abstract：:Currently, exercise-based cardiac rehabilitation (CR) is the only recommended secondary prevention strategy for cardiac patients that attempts to tackle stress and psychosocial wellbeing, but it is under-utilized and lacks a comprehensive curriculum for this purpose; hence there is a critical gap to address psychosoci...

journal_title：Scientific reports

authors： Nijjar PS,Connett JE,Lindquist R,Brown R,Burt M,Pergolski A,Wolfe A,Balaji P,Chandiramani N,Yu X,Kreitzer MJ,Everson-Rose SA

更新日期：2019-12-05 00:00:00

abstract：:Photoswitchable fluorescent proteins with controllable light-dark states and spectral shifts in emission in response to light have led to breakthroughs in the study of cell biology. Nevertheless, conventional photoswitching is not applicable for weakly fluorescent proteins and requires UV light with low depth penetrat...

journal_title：Scientific reports

authors： Harrington WN,Haji MR,Galanzha EI,Nedosekin DA,Nima ZA,Watanabe F,Ghosh A,Biris AS,Zharov VP

更新日期：2016-11-08 00:00:00

abstract：:The purpose of this meta-analysis was to compare the efficacy and safety of regional anesthesia to manage chronic postsurgery pain. A systematic search of PubMed, EmBase, and the Cochrane Central Register of Controlled Trials was performed to identify randomized controlled trials that focused on chronic pain frequency...

journal_title：Scientific reports

authors： Zhou J,Fan Y,Zhong J,Wen X,Chen H

更新日期：2017-04-06 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Liu J,Huang W,Ren C,Wen Q,Liu W,Yang X,Wang L,Zhu B,Zeng L,Feng X,Zhang C,Chen H,Jia W,Zhang L,Xia X,Chen Y

更新日期：2020-04-20 00:00:00

abstract：:Modern flow cytometry instruments have become vital tools for high-throughput analysis of single cells. However, as issues with the cellular labeling techniques often used in flow cytometry have become more of a concern, the development of label-free modalities for cellular analysis is increasingly desired. Non-linear...

journal_title：Scientific reports

authors： Collier BB,Awasthi S,Lieu DK,Chan JW

更新日期：2015-05-29 00:00:00

abstract：:As critical primary producers and recyclers of organic matter, the diversity of marine protists has been extensively explored by high-throughput barcode sequencing. However, classification of short metabarcoding sequences into traditional taxonomic units is not trivial, especially for lineages mainly known by their ge...

journal_title：Scientific reports

authors： Cai R,Kayal E,Alves-de-Souza C,Bigeard E,Corre E,Jeanthon C,Marie D,Porcel BM,Siano R,Szymczak J,Wolf M,Guillou L

更新日期：2020-02-13 00:00:00

abstract：:The small intestine plays an essential role in the health and well-being of animals. Previous studies have shown that Lactobacillus has a protective effect on intestinal morphology, intestinal epithelium integrity and appropriate maturation of gut-associated tissues. Here, gene expression in jejunum tissue of weaned p...

journal_title：Scientific reports

authors： Zhang D,Shang T,Huang Y,Wang S,Liu H,Wang J,Wang Y,Ji H,Zhang R

更新日期：2017-11-17 00:00:00