Young and advanced tumor-some 2D electrodynamic distinctions: melanoma and satellite during a vascular occlusion test: feasibility study.

Abstract:

:Conventional methods of electrobioimpedance imaging are not suited for adequate visualization of the skin electrical impedance landscape (SEL) because they do not provide high spatial resolution at large enough area of view. The skin electrodynamics introscopy (SEI) enabled dynamic spectral imaging of the SEL at 32 × 64 mm2 area with 1 mm spatial resolution. The focus of the study was to investigate the SEL distinguishing features between early and advanced-stage cancer at the model object of melanoma and its satellite. The analysis of the test-induced SEL metamorphoses was carried out at the periods of blood-stop and blood-restoration. It was found that the young tumor could be reliably visualized and distinguished by its antiphase hypoxia-induced response as compared to that of the advanced one. In response to the blood-restoration, an appearance of newly formed SEL clusters pointed out apparently at vascular abnormalities associated with the tumor. Similar SEL clusterization can be supposedly expected in response to any other test factors which affect cell permeability or/and blood viscosity. The proposed approach might be useful for more thorough mapping and staging malignancies.

journal_name

Med Biol Eng Comput

authors

Babich Y,Nuzhdina M,Syniuta S

doi

10.1007/s11517-017-1668-0

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

211-220

issue

2

eissn

0140-0118

issn

1741-0444

pii

10.1007/s11517-017-1668-0

journal_volume

56

pub_type

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