Abstract:
:Conventional methods of electrobioimpedance imaging are not suited for adequate visualization of the skin electrical impedance landscape (SEL) because they do not provide high spatial resolution at large enough area of view. The skin electrodynamics introscopy (SEI) enabled dynamic spectral imaging of the SEL at 32 × 64 mm2 area with 1 mm spatial resolution. The focus of the study was to investigate the SEL distinguishing features between early and advanced-stage cancer at the model object of melanoma and its satellite. The analysis of the test-induced SEL metamorphoses was carried out at the periods of blood-stop and blood-restoration. It was found that the young tumor could be reliably visualized and distinguished by its antiphase hypoxia-induced response as compared to that of the advanced one. In response to the blood-restoration, an appearance of newly formed SEL clusters pointed out apparently at vascular abnormalities associated with the tumor. Similar SEL clusterization can be supposedly expected in response to any other test factors which affect cell permeability or/and blood viscosity. The proposed approach might be useful for more thorough mapping and staging malignancies.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Babich Y,Nuzhdina M,Syniuta Sdoi
10.1007/s11517-017-1668-0subject
Has Abstractpub_date
2018-02-01 00:00:00pages
211-220issue
2eissn
0140-0118issn
1741-0444pii
10.1007/s11517-017-1668-0journal_volume
56pub_type
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