Abstract:
:The purpose of this study was to evaluate the effect of increased blood flow on angiogenesis at the large vessels. The arteriovenous (AV) shunt was made on the thigh of male Wistar rats (n = 27) to increase blood flow, wrapped with artificial skin dermis, which consisted of a silicon outer layer, and isolated from surrounding tissues. Blood flow increased from 2.40 +/- 0.77 to 35.8 +/- 8.7 ml min(-1) (14.9 times), and the shear stress index (relative value of shear stress) increased from 10.7 +/- 3.6 to 73.4 +/- 18.1 (6.85 times) 60 min after the shunt formation. Newly formed vessels were observed around the AV shunt loop. Scanning electron micrographs at the AV shunt vessel lumen showed modified endothelial cells at day 7 and a remarkable number of pores at day 14. The volume of newly formed vessels was increased 12 times from day 5 to day 14. The mechanical factor of shear stress was considered the major stimulator of angiogenesis. This is the first report of electron-microscopic observation of sprouts from a large vessel lumen. The new AV shunt model is useful for basic research on angiogenesis at the large vessels in vivo and, furthermore, could generate vascularised tissues with various cultured cells.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Asano Y,Ichioka S,Shibata M,Ando J,Nakatsuka Tdoi
10.1007/BF02345133keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
126-30issue
1eissn
0140-0118issn
1741-0444journal_volume
43pub_type
杂志文章abstract::This paper presents a novel hybrid medical stent device. This hybrid stent device formed by fractal mesh structures provides a flow-diverting effect and stent-assisted coil embolization. Flow-diverter stents decrease blood flow into an aneurysm to prevent its rupture. In general, the mesh size of a flow-diverter stent...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-015-1374-8
更新日期:2016-05-01 00:00:00
abstract::Results of self-consistent analyses of cells show the possibility of temperature increases at membranes in response to a single nanosecond, high-voltage pulse, at least over small sections of the membrane. Molecular Dynamics simulations indicate that such a temperature increase could facilitate poration, which is one ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-011-0745-z
更新日期:2011-06-01 00:00:00
abstract::The purpose of the study was to explore the application of artificial neural network model in the auxiliary diagnosis of lung cancer and compare the effects of back-propagation (BP) neural network with Fisher discrimination model for lung cancer screening by the combined detections of four biomarkers of p16, RASSF1A a...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-016-1585-7
更新日期:2017-08-01 00:00:00
abstract::Biomechanical models used to estimate joint loads often predict that antagonistic muscles are inactive or underestimate their contributions [3, 5]. This can result in systematic underestimation of muscle force predictions and joint contact forces. To test the feasibility of employing an empirical co-activation ratio t...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-013-1081-2
更新日期:2014-03-01 00:00:00
abstract::A new ambulatory technique for qualitative and quantitative movement analysis of the humerus is presented. 3D gyroscopes attached on the humerus were used to recognize the movement of the arm and to classify it as flexion, abduction and internal/external rotations. The method was first validated in a laboratory settin...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-009-0464-x
更新日期:2009-05-01 00:00:00
abstract::Dengue fever detection and classification have a vital role due to the recent outbreaks of different kinds of dengue fever. Recently, the advancement in the microarray technology can be employed for such classification process. Several studies have established that the gene selection phase takes a significant role in ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-017-1722-y
更新日期:2018-04-01 00:00:00
abstract::A new system capable of generating static and dynamic random-element stereograms is designed and implemented. The stereogram is composed of a rectangle that can be varied in size, element density, orientation, and horizontal and vertical disparities, and can be swept at several velocities. The system is based on an in...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02524687
更新日期:1994-07-01 00:00:00
abstract::The blood cell counting and classification ensures the evaluation and diagnosis of a number of diseases. The analysis of white blood cells (WBCs) permits us to detect the acute lymphoblastic leukemia (ALL), a type of blood cancer that causes fatality when untreated. At present, the morphological analysis of blood cell...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-020-02249-y
更新日期:2020-11-01 00:00:00
abstract::Selective internal radiation therapy (SIRT) using Yttrium-90 loaded glass microspheres injected in the hepatic artery is an emerging, minimally invasive therapy of liver cancer. A personalized intervention can lead to high concentration dose in the tumor, while sparing the surrounding parenchyma. We propose a computat...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-017-1703-1
更新日期:2018-03-01 00:00:00
abstract::The aim of this study was to design a new approach for the acquisition of regional radial strain from the middle portion of the interventricular septum. We designed and wrote a program in Matlab (computer-assisted method) for use on a personal computer so that the septum thickness throughout the cardiac cycle could be...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-007-0222-x
更新日期:2007-09-01 00:00:00
abstract::An algorithm for determining the frequency and propagation time of the gastric slow wave has been designed for integration into a demand gastric pacing system. The algorithm analyses the serosal activity in both the time and frequency domains, and the results are compared to produce a conclusion only when the values a...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02344688
更新日期:2000-01-01 00:00:00
abstract::The main constituent of an ultrasound contrast agent (UCA) is gas-filled microbubbles. An average UCA contains billions per ml. These microbubbles are excellent ultrasound scatterers due to their high compressibility. In an ultrasound field they act as resonant systems, resulting in harmonic energy in the backscattere...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-009-0497-1
更新日期:2009-08-01 00:00:00
abstract::The mechanism of brain contusion has been investigated using a series of three-dimensional (3D) finite element analyses. A head injury model was used to simulate forward and backward rotation around the upper cervical vertebra. Intracranial pressure and shear stress responses were calculated and compared. The results ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02347044
更新日期:2000-05-01 00:00:00
abstract::Cerebral autoregulation controls cerebral blood flow under changing cerebral perfusion pressure. Standards for measurement and analysis of dynamic cerebral autoregulation (dCA) are lacking. In this study, dCA reproducibility, quantified by intraclass correlation coefficient, is evaluated for different methodological a...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-010-0706-y
更新日期:2010-12-01 00:00:00
abstract::In recent years, several studies have been focused on the problem of nonthermal interaction between extremely low-frequency (ELF) electromagnetic fields and cell environment at membrane level. In the paper, to analyse the dynamic effects of weak static and harmonic fields on charged particles, some new considerations ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02446654
更新日期:1993-07-01 00:00:00
abstract::The heart rate variability (HRV) is an indicator of the subject homeostasis alterations. For a healthy individual, the HRV shows a nonlinear behavior, thus requiring a nonlinear approach to provide additional information about HRV dynamics. In this work, the nonlinear techniques, central tendency measure (CTM) and sec...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-015-1390-8
更新日期:2015-11-01 00:00:00
abstract::Deep brain stimulation (DBS) surgery is extensively used in the treatment of movement disorders. Nevertheless, methods to evaluate the clinical response during intraoperative stimulation tests to identify the optimal position for the implantation of the chronic DBS lead remain subjective. In this paper, we describe a ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-016-1559-9
更新日期:2017-05-01 00:00:00
abstract::In electrocardiographic imaging (ECGI), one solves the inverse problem of electrocardiography (ECG) to reconstruct equivalent cardiac sources based on the body surface potential measurements and a mathematical model of the torso. Due to attenuation and spatial smoothing within the torso, this inverse problem is ill-po...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-019-02018-6
更新日期:2019-10-01 00:00:00
abstract::Quantitative analysis and detection of electroencephalogram (EEG) recordings during evoked activities is essential for clinical diagnosis on neurological disorders. However, the process of interpreting EEG is time consuming for electroencephalographers (EEGers). In this study, an automatic EEG interpretation system co...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-010-0688-9
更新日期:2011-02-01 00:00:00
abstract::Atrial fibrillation (AF) is the most common cardiac arrhythmia with episodes that may terminate spontaneously in the first stages of the disease. On the other hand, when the arrhythmia is not self-terminating, normal sinus rhythm (NSR) restoration use to be required to reduce the risk of stroke and improve cardiac out...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-008-0348-5
更新日期:2008-07-01 00:00:00
abstract::Functional magnetic resonance imaging (FMRI) is an imaging technique for determining which regions of the brain are activated in response to a stimulus or event. Early FMRI experiment paradigms were based upon those used in positron emission tomography (PET), i.e. employing a block design consisting of extended period...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02347541
更新日期:2004-09-01 00:00:00
abstract::Understanding the hemodynamics surrounding the venous valve environment is of a great importance for prosthetic valves design. The present study aims to evaluate the effect of leaflets' stiffening process on the venous valve hemodynamics, valve's failure on the next proximal valve hemodynamics and valve's failure in a...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-016-1575-9
更新日期:2017-06-01 00:00:00
abstract::We propose a new method for breast X-ray image adaptive enhancement that combines nonsubsampled contourlet transform (NSCT) with the whale optimization algorithm (WOA). First, the mammography X-ray image was processed by histogram equalization to ensure global image contrast. The processed image was then decomposed in...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-019-02022-w
更新日期:2019-10-01 00:00:00
abstract::Haematocrit and temperature effects on resistivity are investigated using the electrical impedance method. Measurements are made extensively for pig's blood. The experimental set-up basically involves four ring electrodes being placed around a wooden probe that is subsequently immersed into a syringe containing pig's ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02523215
更新日期:1998-07-01 00:00:00
abstract::Recent studies were investigated that report spontaneous oscillations of cerebral perfusion in the very low-frequency range (0.01-0.04 Hz), emphasising details of spectral estimation. The effects of different spectral estimation procedures were compared, using simulated and clinical data. It was shown that data detren...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02343541
更新日期:2003-01-01 00:00:00
abstract::This article presents a stimulation control method using a uniaxial gyroscope measuring angular velocity of the shank in the sagittal plane, to control functional electrical stimulation of the triceps surae to improve push-off of stroke subjects during gait. The algorithm is triggered during each swing phase of gait w...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-009-0539-8
更新日期:2009-11-01 00:00:00
abstract::A comparison of auditory and visual perception of scatterplots showed similar correlation estimation performance in both modalities. The present study replicated this experiment using electrotactile (electrocutaneous) presentation of scatterplots on the fingertips and abdomen, as well as visual presentation. The corre...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02345967
更新日期:2005-03-01 00:00:00
abstract::Respiratory sinus arrhythmia (RSA) is the variation of heart rate (or RR interval) in phase with respiration and has been extensively studied. However, the effect of respiration on atrioventricular conduction delay (and hence PR interval length) has not yet received much attention. This work reports on measurements of...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02345298
更新日期:2002-11-01 00:00:00
abstract::The aim of the study was to investigate the effect of signal length on the performance of a signal source separation method, independent component analysis (ICA), when extracting the visual evoked potential (EP) lambda wave from saccade-related electro-encephalogram (EEG) waveforms. A method was devised that enabled t...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02348134
更新日期:2002-03-01 00:00:00
abstract::The aim of this study was to investigate conventionally and early loaded titanium and titanium-zirconium alloy implants by three-dimensional finite element stress analysis. Three-dimensional model of a dental implant was created and a thread area was established as a region of interest in trabecular bone to study a lo...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-015-1256-0
更新日期:2015-05-01 00:00:00