Abstract:
:Recent studies were investigated that report spontaneous oscillations of cerebral perfusion in the very low-frequency range (0.01-0.04 Hz), emphasising details of spectral estimation. The effects of different spectral estimation procedures were compared, using simulated and clinical data. It was shown that data detrending, as used in many studies, can lead to an artifactual peak in the very low-frequency region of estimated power spectra, indicating that the peak cannot be taken as evidence of physiological oscillations. A quantitative, reliable method is described that can be used to assess very low-frequency oscillations. Using the method, very low-frequency oscillations were found in ten out of 17 healthy adults measured with transcranial Doppler (average frequency, 0.021 +/- 0.007 Hz, mean +/- SD), confirming earlier findings based on visual inspection of data.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Müller T,Reinhard M,Oehm E,Hetzel A,Timmer Jdoi
10.1007/BF02343541keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
69-74issue
1eissn
0140-0118issn
1741-0444journal_volume
41pub_type
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