Abstract：
:Trabecular bone has a complicated porous microstructure and consists of interconnected plates and rods known as trabeculae. The microarchitecture of the trabeculae contributes to load distribution capacity and, particularly, the optimal bone strength. Many previous studies have shown that morphological parameters are used to characterize the microarchitecture of trabecular bone, but little is known about the mechanical role of trabecular morphology in the context of load-bearing behavior. Therefore, this study proposes a new segmentation method for examining the morphology of trabecular structure foci of load-bearing capability. A micro-finite element model of trabecular bone was obtained from the fourth lumbar vertebra on the basis of a three-dimensionally reconstructed micro-computed tomography (CT) image. We used an asymptotic homogenization method to determine microscopic stress by applying three unidirectional compressive loads in the vertical, anteroposterior, and right-left axes of two trabecular bone volumes. We then classified the complicated trabecular microstructure into three segments: primary and secondary trabeculae and trabeculae of no contribution. Next, a dynamic analysis was conducted by applying a force impulse load. The result indicated that 1/3 of the trabecular volume functions as primary trabecula. The morphology of the trabecular network could be visualized successfully highlighting the percolation of the stress wave in the primary trabecular segment. Further, we found that the role of the plate-like structures was that of a hub in the trabecular network system.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Basaruddin KS,Takano N,Yoshiwara Y,Nakano Tdoi
10.1007/s11517-012-0951-3subject
Has Abstractpub_date
2012-10-01 00:00:00pages
1091-103issue
10eissn
0140-0118issn
1741-0444journal_volume
50pub_type
杂志文章abstract：:Spinal cord injury patients are under daily risk for developing deep tissue injury which is a severe pressure ulcer that initiates in soft tissues at the bones' proximity. We aimed to formulate a patient-specific biomechanical model that can continuously monitor internal tissue stresses in real time. We adopted a form...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-011-0754-y
更新日期：2011-04-01 00:00:00
abstract：:A method for accurately finding cardiac bidomain conductivity parameters is a crucial part of efforts to study and understand the electrical functioning of the heart. The bidomain model considers current flowing along (longitudinal) and across (transverse) sheets of cardiac fibres, as well as between these sheets (nor...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-013-1101-2
更新日期：2013-12-01 00:00:00
abstract：:The effect of flow direction on the morphology of cultured bovine aortic endothelial cells is studied. Fully confluent endothelial cells cultured on glass were subjected to a fluid-imposed shear stress of 2 Pa for 20 min and 24 h using a parallel plate flow chamber. Experiments on shear flow exposure were performed fo...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02522869
更新日期：1998-01-01 00:00:00
abstract：:Taking advantage of motion sensing technology, a quantitative assessment method for lower limbs motor function of cerebral palsy (CP) based on the gross motor function measurement (GMFM)-24 scale was explored in this study. According to the motion analysis on GMFM-24 scale, we translated the assessment problem of GMFM...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-019-02076-w
更新日期：2020-01-01 00:00:00
abstract：:The objective of the present work was to develop automated methods for the compressed tracheal breathing sound analysis. Overnight tracheal breathing sound was recorded from ten apnoea patients. From each patient, three different types of tracheal sound deflection pattern, each of 10 min duration, were visually scored...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-008-0317-z
更新日期：2008-04-01 00:00:00
abstract：:A new transducer has been developed, based on an inductive principle, for recording fetal movements and sounds. The compliance of this transducer, the INductive PHOno-sensor (INPHO), can be matched to that of the maternal abdomen to provide an optimal transfer of displacement between maternal abdomen and transducer. I...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02441655
更新日期：1991-07-01 00:00:00
abstract：:In this paper, the limitations of the conventional formula for the computation of peripheral blood flow from impedance plethysmograms are highlighted, and a correction to the formula is suggested. A conductivity cell experiment is described to show the dependence of the value of the blood flow index (BFI), obtained fr...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02524237
更新日期：1994-11-01 00:00:00
abstract：:Smoothing and differentiation of noisy signals are common problems whenever it is difficult or impossible to obtain derivatives by direct measurement. In biomechanics body displacements are frequently assessed and these measurements are affected by noise. To avoid high-frequency noise magnification, data filtering bef...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02441963
更新日期：1990-09-01 00:00:00
abstract：:Disappointing results for total ankle replacement have been explained by poor knowledge of the mechanics of the intact and replaced joints. Dynamic simulation tools have the capacity to simulate dynamic conditions that occur in human joints. The Working Model 2D tool was used to simulate the mechanics of the intact an...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02348124
更新日期：2002-03-01 00:00:00
abstract：:The lactate threshold is used by athletes to optimise the intensity during exercise. It is of interest to measure the threshold on the very day and during the present sport activity. Steady state ergometer tests have been performed on 40 individuals to compare the threshold found by an electro acoustic sensor system t...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-008-0373-4
更新日期：2008-09-01 00:00:00
abstract：:The scapholunate ligament stabilizes the scaphoid and lunate of the proximal row in the wrist which allows for proper force transmission with the radius and ulna. Damage to this structure degenerates into arthritis and disability. Controversy exists over the best technique to restore function and reduce pain. A three-...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-019-01971-6
更新日期：2019-07-01 00:00:00
abstract：:Magnetic nanoparticles for therapy and diagnosis are at the leading edge of the rapidly developing field of bionanotechnology. In this study, we have theoretically studied motion of magnetic nano- as well as micro-particles in the field of cylindrical Halbach array of permanent magnets. Magnetic flux density was model...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-010-0636-8
更新日期：2010-08-01 00:00:00
abstract：:A building block-based software framework was developed to simulate electrophysiological networks. The synaptic potentials generated during neurotransmission were simulated in an existing discrete bidomain model of smooth muscle, using cubic, three-dimensional grids of varying sizes. The model is automatically derived...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02345322
更新日期：2003-09-01 00:00:00
abstract：:The development of computer technology now allows the quick and efficient automatic fluorescence microscopy generation of a large number of images of proteins in specific subcellular compartments using fluorescence microscopy. Digital image processing and pattern recognition technology can easily classify these images...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-018-01946-z
更新日期：2019-06-01 00:00:00
abstract：:Results of self-consistent analyses of cells show the possibility of temperature increases at membranes in response to a single nanosecond, high-voltage pulse, at least over small sections of the membrane. Molecular Dynamics simulations indicate that such a temperature increase could facilitate poration, which is one ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-011-0745-z
更新日期：2011-06-01 00:00:00
abstract：:Soleus muscle flap as coverage tissue is a possible surgical solution adopted to cover the wounds due to open fractures. Despite this procedure presents many clinical advantages, relatively poor information is available about the loss of functionality of triceps surae of the treated leg. In this study, a group of pati...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-020-02286-7
更新日期：2021-01-01 00:00:00
abstract：:Using images from the Image Database Consortium and Image Database Resource Initiative (LIDC-IDRI), we developed a methodology for classifying lung nodules. The proposed methodology uses image processing and pattern recognition techniques. To classify volumes of interest into nodules and non-nodules, we used shape mea...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1582-x
更新日期：2017-08-01 00:00:00
abstract：:The study and applications of in vivo skin optics have been openly documented as early as the year 1954, or possibly earlier. To date, challenges in analyzing the complexities of this field remain, with wide scopes requiring more scrutiny. Recent advances in spectroscopic research and multivariate analytics allow a cl...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章,评审
doi：10.1007/s11517-019-02077-9
更新日期：2020-06-01 00:00:00
abstract：:Spontaneous activity of specific regions (e.g., the Sinoatrial node, SAN) is essential for the normal activation sequence of the heart and also serve as a primary means of modulating cardiac rate by sympathetic tone and circulating catecholamines. The mechanisms of how a small SAN region can electrically drive a much ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章,评审
doi：10.1007/s11517-006-0102-9
更新日期：2007-02-01 00:00:00
abstract：:The aim of this study was to evaluate feasibility and reproducibility of quantitative assessment of colonic morphology on CT colonography (CTC). CTC datasets from 60 patients with optimal colonic distension were assessed using prototype software. Metrics potentially associated with poor endoscopic performance were cal...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1529-2
更新日期：2017-03-01 00:00:00
abstract：:Electrical and mechanical stimulation of the oesophagus has been recently proposed to examine the physiological effects of autonomic stimulation in humans. Cortical evoked potentials (EPs) to oesophageal stimulation provide an assessment of afferent fibres and central processing. However, habituation takes place durin...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02534088
更新日期：1997-07-01 00:00:00
abstract：:During scoliosis instrumentation surgery, it is difficult for surgeons fully to track vertebral motion in 3D, because only the posterior elements of the spine are exposed. Different intra-operative modelling approaches are evaluated using a registration technique that matches intra-operative measurements with a 3D pre...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02513328
更新日期：1999-07-01 00:00:00
abstract：:We present a novel method to iteratively calculate discrete Fourier transforms for discrete time signals with sample time intervals that may be widely nonuniform. The proposed recursive Fourier transform (RFT) does not require interpolation of the samples to uniform time intervals, and each iterative transform update ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-009-0461-0
更新日期：2009-07-01 00:00:00
abstract：:In this study, we propose an integrated tooth segmentation and gingival tissue deformation simulation framework used to design and evaluate the orthodontic treatment plan especially with invisible aligners. Firstly, the bio-characteristics information of the digital impression is analyzed quantitatively and demonstrat...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-020-02230-9
更新日期：2020-10-01 00:00:00
abstract：:When the rib cage and abdomen are compressed during cardiopulmonary resuscitation (CPR), the effect on intrathoracic pressure, and therefore on haemodynamics, cannot be quantitatively predicted without a physiologically based mathematical model of chest wall dynamics. Using such a model, we compared model simulations ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02441676
更新日期：1990-01-01 00:00:00
abstract：:Greater trochanter (GT) stabilization techniques following a fracture or an osteotomy are still showing high levels of postoperative complications. Understanding the effect of femoral neck cut placement, cable tension and muscles forces on GT fragment displacements could help surgeons optimize their techniques. A 3D f...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-012-0892-x
更新日期：2012-04-01 00:00:00
abstract：:Atrial fibrillation (AF) is the most common cardiac arrhythmia with episodes that may terminate spontaneously in the first stages of the disease. On the other hand, when the arrhythmia is not self-terminating, normal sinus rhythm (NSR) restoration use to be required to reduce the risk of stroke and improve cardiac out...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-008-0348-5
更新日期：2008-07-01 00:00:00
abstract：:Understanding the hemodynamics surrounding the venous valve environment is of a great importance for prosthetic valves design. The present study aims to evaluate the effect of leaflets' stiffening process on the venous valve hemodynamics, valve's failure on the next proximal valve hemodynamics and valve's failure in a...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1575-9
更新日期：2017-06-01 00:00:00
abstract：:Precise segmentation of stroke lesions from brain magnetic resonance (MR) images poses a challenging task in automated diagnosis. In this paper, we proposed a new method called watershed-based lesion segmentation algorithm (WLSA), which is a novel intensity-based segmentation technique used to delineate infarct lesion...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-017-1726-7
更新日期：2018-05-01 00:00:00
abstract：:Protein glycosylation is one of the most important and complex post-translational modification that provides greater proteomic diversity than any other post-translational modification. Fast and reliable computational methods to identify glycosylation sites are in great demand. Two key issues, feature encoding and feat...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-015-1268-9
更新日期：2015-06-01 00:00:00
