Abstract:
:Spontaneous activity of specific regions (e.g., the Sinoatrial node, SAN) is essential for the normal activation sequence of the heart and also serve as a primary means of modulating cardiac rate by sympathetic tone and circulating catecholamines. The mechanisms of how a small SAN region can electrically drive a much larger atrium, or how a small ectopic focus can drive surrounding ventricular or atrial tissue are complex, and involve the membrane properties and electrical coupling within the SAN or focus region as well as the membrane properties, coupling conductance magnitudes and also regional distribution within the surrounding tissue. We review here studies over the past few decades in which mathematical models and experimental studies have been used to determine some of the design principles of successful propagation from a pacemaking focus. These principles can be briefly summarized as (1) central relative uncoupling to protect the spontaneously firing cells from too much electrotonic inhibition, (2) a transitional region in which the cell type and electrical coupling change from the central SAN region to the peripheral atrial region, and (3) a distributed anisotropy to facilitate focal activity.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Joyner RW,Wilders R,Wagner MBdoi
10.1007/s11517-006-0102-9subject
Has Abstractpub_date
2007-02-01 00:00:00pages
177-87issue
2eissn
0140-0118issn
1741-0444journal_volume
45pub_type
杂志文章,评审abstract::When the microvascular blood perfusion in human skin is measured by photoplethysmography (PPG), infra-red light (800-960 nm) is normally used as the light source. The PPG signal, which consists of a pulsatile (AC) and a slowly fluctuating (DC) component, was studied at different optical wavelengths utilising optical f...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02446295
更新日期:1991-01-01 00:00:00
abstract::The first in vivo evaluation of a pO2 sensor constructed with a novel copolymer is described. The performance of the sensor is assessed under dynamic conditions in vitro and in vivo. This sensor is more stable and reliable than the control sensor with a heparin-treated polyethylene membrane. ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02511245
更新日期:1996-07-01 00:00:00
abstract::Loop-mediated isothermal amplification or LAMP has been identified to be an efficient technology for point-of-care diagnostics. Paper-based LAMP technique has tremendous potential in replacing the existing tube-based technology as the manufacturing cost of a paper-based device is comparatively lower and easy-to-use. L...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-019-02082-y
更新日期:2020-02-01 00:00:00
abstract::The recording of sounds over the orbit of the eye has been found to be useful in the detection of intracranial aneurysms. A hydrophone for auscultation over the eye has been developed and is tested under controlled conditions. The tests consist of measurement over the eyes in three healthy volunteers at rest, during v...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02523031
更新日期:1995-03-01 00:00:00
abstract::Spectral analysis of heart rate variability (HRV) is a widely accepted approach for assessment of cardiac autonomic function and its relationship to numerous disorders and diseases. As a rule, the non-parametric methods for HRV spectral analysis are tested using the integral pulse frequency modulation (IPFM) model. Ho...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02345290
更新日期:2001-05-01 00:00:00
abstract::The CellDrum technology (The term 'CellDrum technology' includes a couple of slightly different technological setups for measuring lateral mechanical tension in various types of cell monolayers or 3D-tissue constructs) was designed to quantify the contraction rate and mechanical tension of self-exciting cardiac myocyt...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-009-0552-y
更新日期:2010-01-01 00:00:00
abstract::Mammography is a widely used screening tool and is the gold standard for the early detection of breast cancer. The classification of breast masses into the benign and malignant categories is an important problem in the area of computer-aided diagnosis of breast cancer. A small dataset of 57 breast mass images, each wi...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-006-0077-6
更新日期:2006-08-01 00:00:00
abstract::Automatic identification of landmarks in cephalometry is very important and useful for orthognathic surgery. A computerised automatic cephalometric analysis system (CACAS), based on image processing, is presented. For an original X-ray image, median filtering and histogram equalisation are used to improve image qualit...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02345280
更新日期:2001-05-01 00:00:00
abstract::The objective of this study was to evaluate the effect of following combined treatment with parathyroid hormone (1-34) (PTH) and beta-tricalcium phosphate (β-TCP) on local bone formation in a rat 3-mm critical-size defect at distal femur. Twelve weeks after bilateral ovariectomy (OVX) and sham operation (sham), all an...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-015-1402-8
更新日期:2016-09-01 00:00:00
abstract::Protein glycosylation is one of the most important and complex post-translational modification that provides greater proteomic diversity than any other post-translational modification. Fast and reliable computational methods to identify glycosylation sites are in great demand. Two key issues, feature encoding and feat...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-015-1268-9
更新日期:2015-06-01 00:00:00
abstract::This work addresses the problem of estimating the conduction velocity (CV) of single motor unit (MU) action potentials from surface EMG signals detected with linear electrode arrays during voluntary muscle contractions. In ideal conditions, that is without shape or scale changes of the propagating signals and with add...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02344807
更新日期:2001-03-01 00:00:00
abstract::In this study, we propose an integrated tooth segmentation and gingival tissue deformation simulation framework used to design and evaluate the orthodontic treatment plan especially with invisible aligners. Firstly, the bio-characteristics information of the digital impression is analyzed quantitatively and demonstrat...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-020-02230-9
更新日期:2020-10-01 00:00:00
abstract::Several 3D reconstruction techniques deriving from stereoradiographic DLT have been presented during the last 15 years, but these techniques have usually been limited in accuracy because of the small number of corresponding anatomical landmarks identified on both radiographs. A new technique has recently been proposed...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02344797
更新日期:2001-03-01 00:00:00
abstract::Disturbed cerebrospinal fluid (CSF) dynamics are part of the pathophysiology of normal pressure hydrocephalus (NPH) and can be modified and treated with shunt surgery. This study investigated the contribution of established CSF dynamic parameters to AMP(mean), a prognostic variable defined as mean amplitude of cardiac...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-013-1110-1
更新日期:2014-01-01 00:00:00
abstract::Calcific aortic valve disease (CAVD) is characterized by calcification accumulation and thickening of the aortic valve cusps, leading to stenosis. The importance of fluid flow shear stress in the initiation and regulation of CAVD progression is well known and has been studied recently using fluid-structure interaction...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-016-1458-0
更新日期:2016-11-01 00:00:00
abstract::High-frequency nanosecond-pulsed electric fields were recently introduced for tumor or abnormal tissue ablation to solve some problems of conventional electroporation. However, it is necessary to study the thermal effects of high-field-intensity nanosecond pulses inside tissues. The multi-parametric analysis performed...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-016-1589-3
更新日期:2017-07-01 00:00:00
abstract::Therapeutic hypothermia is a treatment method to reduce brain injuries after stroke, especially for cerebral ischemia. This study investigates in the temperature distribution of the head within selective brain cooling (SBC). Anatomically accurate geometries based on CT images of head and neck regions are used to devel...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-019-01962-7
更新日期:2019-06-01 00:00:00
abstract::The passive and active properties of the cochlear outer hair cell are studied. The outer hair cell is currently considered the major candidate for the active component of mammalian hearing. Understanding of its properties may explain the amplification and sharp frequency selectivity of the ear. To analyse the cell beh...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02513294
更新日期:1999-03-01 00:00:00
abstract::The aim of the study was to compare experimentally conduction velocity (CV) estimates obtained with different estimation methods based on surface electromyogram (EMG) signals detected using five spatial filters. The filters investigated were the longitudinal single and double differential, transverse single and double...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02348440
更新日期:2003-05-01 00:00:00
abstract::Multi-scale modeling of the musculoskeletal system plays an essential role in the deep understanding of complex mechanisms underlying the biological phenomena and processes such as bone metabolic processes. Current multi-scale models suffer from the isolation of sub-models at each anatomical scale. The objective of th...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章,评审
doi:10.1007/s11517-016-1572-z
更新日期:2017-06-01 00:00:00
abstract::Past decades witnessed the expansion of linear signal processing methods in numerous biomedical applications. However, the nonlinear behavior of biomedical signals revived the interest in nonlinear signal processing methods such as higher-order statistics, in particular higher-order cumulants (HOC). In this paper, HOC...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-015-1394-4
更新日期:2015-11-01 00:00:00
abstract::In electrocardiographic imaging (ECGI), one solves the inverse problem of electrocardiography (ECG) to reconstruct equivalent cardiac sources based on the body surface potential measurements and a mathematical model of the torso. Due to attenuation and spatial smoothing within the torso, this inverse problem is ill-po...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-019-02018-6
更新日期:2019-10-01 00:00:00
abstract::It is clinically well-established that minimally invasive subcutaneous continuous glucose monitoring (CGM) sensors can significantly improve diabetes treatment. However, CGM readings are still not as reliable as those provided by standard fingerprick blood glucose (BG) meters. In addition to unavoidable random measure...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-014-1226-y
更新日期:2015-12-01 00:00:00
abstract::Thousands of patients receive human tissue grafts every year. Developments in cell and tissue engineering have also increased considerably the number of available products of human origin. France has very strict regulations, in part stimulated by problems of public health and ethics that have emerged in recent years a...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02344783
更新日期:2000-03-01 00:00:00
abstract::The physiological parameters of blood such as extracellular Na(+), K(+), Cl(-), pH, 2,3-DPG and ATP and the complex electrical impedance were measured using whole blood samples from 31 male donors (21 donors form the training set and ten donors were used for testing), on the 0th, 10th and 21st day of blood bank storag...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-007-0206-x
更新日期:2007-07-01 00:00:00
abstract::Density assessment and lesion localization in breast MRI require accurate segmentation of breast tissues. A fast, computerized algorithm for volumetric breast segmentation, suitable for multi-centre data, has been developed, employing 3D bias-corrected fuzzy c-means clustering and morphological operations. The full br...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-016-1484-y
更新日期:2017-01-01 00:00:00
abstract::Time-varying filtering techniques are applied to the problem of baseline correction by letting the cut-off frequency of a linear filter be controlled by the low-frequency properties of the ECG signal. The time-varying filter is implemented as a bank of linear low-pass filters, in which each filter has a slightly diffe...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02441986
更新日期:1993-09-01 00:00:00
abstract::Variations in the amplitude and period of essential and Parkinsonian tremors were studied. It was found that the variations in frequency (or period) were mostly similar to the white noise, with the standard deviation typically less than 10% of the mean, whereas the variations in amplitude were much larger, with standa...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02344710
更新日期:2004-05-01 00:00:00
abstract::Both invasive left-ventricular pressure measurements and non-invasive colour M-mode echographic measurements have shown the existence of intraventricular pressure gradients (IVPGs) during early filling. The mechanisms responsible for these IVPG cannot be completely explained by the experiments. Therefore a one-dimensi...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02513338
更新日期:1999-07-01 00:00:00
abstract::The long QT syndrome (LQTS) is a genetic disorder, typically characterized by a prolonged QT interval in the ECG due to abnormal cardiac repolarization. LQTS may lead to syncopal episodes and sudden cardiac death. Various parameters based on T-wave morphology, as well as the QT interval itself have been shown to be us...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-006-0061-1
更新日期:2006-07-01 00:00:00