Classification of the long-QT syndrome based on discriminant analysis of T-wave morphology.

Abstract:

:The long QT syndrome (LQTS) is a genetic disorder, typically characterized by a prolonged QT interval in the ECG due to abnormal cardiac repolarization. LQTS may lead to syncopal episodes and sudden cardiac death. Various parameters based on T-wave morphology, as well as the QT interval itself have been shown to be useful discriminators, but no single ECG parameter has been sufficient to solve the diagnostic problem. In this study we present a method for discrimination among persons with a normal genotype and those with mutations in the KCNQ1 (KvLQT1 or LQT1) and KCNH2 (HERG or LQT2) genes on the basis of parameters describing T-wave morphology in terms of duration, asymmetry, flatness and amplitude. Discriminant analyses based on 4 or 5 parameters both resulted in perfect discrimination in a learning set of 36 subjects. In both cases cross-validation of the resulting classifiers showed no misclassifications either.

journal_name

Med Biol Eng Comput

authors

Struijk JJ,Kanters JK,Andersen MP,Hardahl T,Graff C,Christiansen M,Toft E

doi

10.1007/s11517-006-0061-1

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

543-9

issue

7

eissn

0140-0118

issn

1741-0444

journal_volume

44

pub_type

杂志文章
  • CFD simulations for paper-based DNA amplification reaction (LAMP) of Mycobacterium tuberculosis-point-of-care diagnostic perspective.

    abstract::Loop-mediated isothermal amplification or LAMP has been identified to be an efficient technology for point-of-care diagnostics. Paper-based LAMP technique has tremendous potential in replacing the existing tube-based technology as the manufacturing cost of a paper-based device is comparatively lower and easy-to-use. L...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-019-02082-y

    authors: Das D,Panigrahi PK

    更新日期:2020-02-01 00:00:00

  • Intraoperative acceleration measurements to quantify improvement in tremor during deep brain stimulation surgery.

    abstract::Deep brain stimulation (DBS) surgery is extensively used in the treatment of movement disorders. Nevertheless, methods to evaluate the clinical response during intraoperative stimulation tests to identify the optimal position for the implantation of the chronic DBS lead remain subjective. In this paper, we describe a ...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-016-1559-9

    authors: Shah A,Coste J,Lemaire JJ,Taub E,Schüpbach WMM,Pollo C,Schkommodau E,Guzman R,Hemm-Ode S

    更新日期:2017-05-01 00:00:00

  • Prediction of apoptosis protein subcellular location based on position-specific scoring matrix and isometric mapping algorithm.

    abstract::Apoptosis proteins are related to many diseases. Obtaining the subcellular localization information of apoptosis proteins is helpful to understand the mechanism of diseases and to develop new drugs. At present, the researchers mainly focus on the primary protein sequences, so there is still room for improvement in the...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-019-02045-3

    authors: Ruan X,Zhou D,Nie R,Hou R,Cao Z

    更新日期:2019-12-01 00:00:00

  • Improved photomultiplier tube for positron emission tomography.

    abstract::The paper describes an investigation in which it is shown that small positive voltage pulses applied to an external conductor placed against the photocathode of a photomultiplier tube can be used to switch the photocathode completely off for the duration of the pulses. This suggests that a photomultiplier tube with a ...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02441486

    authors: Woldeselassie T

    更新日期:1989-05-01 00:00:00

  • Control of triceps surae stimulation based on shank orientation using a uniaxial gyroscope during gait.

    abstract::This article presents a stimulation control method using a uniaxial gyroscope measuring angular velocity of the shank in the sagittal plane, to control functional electrical stimulation of the triceps surae to improve push-off of stroke subjects during gait. The algorithm is triggered during each swing phase of gait w...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-009-0539-8

    authors: Monaghan CC,van Riel WJ,Veltink PH

    更新日期:2009-11-01 00:00:00

  • The past, present, and prospective on UV-VIS-NIR skin photonics and spectroscopy-a wavelength guide.

    abstract::The study and applications of in vivo skin optics have been openly documented as early as the year 1954, or possibly earlier. To date, challenges in analyzing the complexities of this field remain, with wide scopes requiring more scrutiny. Recent advances in spectroscopic research and multivariate analytics allow a cl...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章,评审

    doi:10.1007/s11517-019-02077-9

    authors: Poh AH,Adikan FRM,Moghavvemi M

    更新日期:2020-06-01 00:00:00

  • Analysis of amplitude and frequency variations of essential and Parkinsonian tremors.

    abstract::Variations in the amplitude and period of essential and Parkinsonian tremors were studied. It was found that the variations in frequency (or period) were mostly similar to the white noise, with the standard deviation typically less than 10% of the mean, whereas the variations in amplitude were much larger, with standa...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02344710

    authors: Gao JB

    更新日期:2004-05-01 00:00:00

  • Technique for the evaluation of derivatives from noisy biomechanical displacement data using a model-based bandwidth-selection procedure.

    abstract::Smoothing and differentiation of noisy signals are common problems whenever it is difficult or impossible to obtain derivatives by direct measurement. In biomechanics body displacements are frequently assessed and these measurements are affected by noise. To avoid high-frequency noise magnification, data filtering bef...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02441963

    authors: D'Amico M,Ferrigno G

    更新日期:1990-09-01 00:00:00

  • Some technical aspects of magnetic stimulation coil design with the ferromagnetic effect.

    abstract::The performance of the stimulation coil in a magnetic nerve stimulator can be improved by attaching a ferromagnetic structure to the coil. This reduces heat generation at the coil and increases magnetic field strength for a given unit of current. Some technical aspects of the design of a stimulation coil with a ferrom...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02345312

    authors: Han BH,Lee SY,Kim JH,Yi JH

    更新日期:2003-09-01 00:00:00

  • A method for detecting myocardial abnormality by using a current-ratio map calculated from an exercise-induced magnetocardiogram.

    abstract::A method for making a current-ratio map to determine the ischaemic area of angina pectoris (AP) patients has been developed. This method uses a current-arrow map calculated using a ORS wave from 64-channel magnetocardiogram (MCG) signals. The current-ratio map can be calculated from the ratio of an exercise-induced cu...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02345263

    authors: Kandori A,Kanzaki H,Miyatake K,Hashimoto S,Itoh S,Tanaka N,Miyashita T,Tsukada K

    更新日期:2001-01-01 00:00:00

  • Interaction between steady flow and individualised compliant segments: application to upper airways.

    abstract::To describe upper airway obstruction in patients with sleep apnea syndrome, the steady state solutions of a simple model of local pharyngeal obstruction were studied. Importantly, the present model embodies a series of two individualised elements, each having its own compliance, which enables the consideration, from a...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02510972

    authors: Fodil R,Ribreau C,Louis B,Lofaso F,Isabey D

    更新日期:1997-11-01 00:00:00

  • Cardiac anisotropy in boundary-element models for the electrocardiogram.

    abstract::The boundary-element method (BEM) is widely used for electrocardiogram (ECG) simulation. Its major disadvantage is its perceived inability to deal with the anisotropic electric conductivity of the myocardial interstitium, which led researchers to represent only intracellular anisotropy or neglect anisotropy altogether...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-009-0472-x

    authors: Potse M,Dubé B,Vinet A

    更新日期:2009-07-01 00:00:00

  • Space-time network connectivity and cortical activations preceding spike wave discharges in human absence epilepsy: a MEG study.

    abstract::To describe the spatial and temporal profiles of connectivity networks and sources preceding generalized spike-and-wave discharges (SWDs) in human absence epilepsy. Nonlinear associations of MEG signals and cluster indices obtained within the framework of graph theory were determined, while source localization in the ...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-011-0778-3

    authors: Gupta D,Ossenblok P,van Luijtelaar G

    更新日期:2011-05-01 00:00:00

  • A fully automated hybrid human sperm detection and classification system based on mobile-net and the performance comparison with conventional methods.

    abstract::Sperm morphology, as an indicator of fertility, is a critical tool in semen analysis. In this study, a smartphone-based hybrid system that fully automates the sperm morphological analysis is introduced with the aim of eliminating unwanted human factors. Proposed hybrid system consists of two progressive steps: automat...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-019-02101-y

    authors: Ilhan HO,Sigirci IO,Serbes G,Aydin N

    更新日期:2020-05-01 00:00:00

  • Plasma detection of NO by a catheter.

    abstract::Nitric oxide (NO) released by endothelial cells in response to hemodynamic shear stress is a key controller molecule of the vascular functions and antiatherogenic mechanisms. Endothelial dysfunction is associated with increased cardiovascular events. Therefore, several indirect techniques have been employed to evaluat...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-008-0333-z

    authors: Goto M,Mochizuki S

    更新日期:2008-05-01 00:00:00

  • A mechatronic valve in the management of hydrocephalus: methods and performance.

    abstract::The problem of excess cerebrospinal fluid in the brain (hydrocephalus) is generally managed using a passive pressure or flow regulated mechanical shunt. Despite the success of such devices, they have been plagued with a number of problems. It is desirable to have a shunt valve that responds dynamically to the changing...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-010-0716-9

    authors: Momani L,Al-Nuaimy W,Al-Jumaily M,Mallucci C

    更新日期:2011-01-01 00:00:00

  • Estimation of single motor unit conduction velocity from surface electromyogram signals detected with linear electrode arrays.

    abstract::This work addresses the problem of estimating the conduction velocity (CV) of single motor unit (MU) action potentials from surface EMG signals detected with linear electrode arrays during voluntary muscle contractions. In ideal conditions, that is without shape or scale changes of the propagating signals and with add...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02344807

    authors: Farina D,Muhammad W,Fortunato E,Meste O,Merletti R,Rix H

    更新日期:2001-03-01 00:00:00

  • A multi-electrode array and inversion technique for retrieving six conductivities from heart potential measurements.

    abstract::A method for accurately finding cardiac bidomain conductivity parameters is a crucial part of efforts to study and understand the electrical functioning of the heart. The bidomain model considers current flowing along (longitudinal) and across (transverse) sheets of cardiac fibres, as well as between these sheets (nor...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-013-1101-2

    authors: Johnston BM,Johnston PR

    更新日期:2013-12-01 00:00:00

  • Activating function of needle electrodes in anisotropic tissue.

    abstract::We present an analytical solution for the electrical potential and activating function (AF) established by cylindrical needle electrodes in anisotropic tissue. We compare this activating function to (1) AF computed assuming line-source electrodes and (2) AF computed using a finite element program. The results show tha...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-009-0508-2

    authors: Guo L,Cranford JP,Neu JC,Neu WK

    更新日期:2009-09-01 00:00:00

  • CT analysis of the use of the electrical impedance technique to estimate local oedema in the extremities in patients with lymphatic obstruction.

    abstract::The aim of the study is to establish the validity of the use of the electrical impedance technique for estimating local oedema in extremities through comparison with computed-tomography (CT) analysis. Eight healthy women (group 1) and nine women with unilateral leg oedema following chronic lymphatic obstruction (group...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02522859

    authors: Watanabe R,Kotoura H,Morishita Y

    更新日期:1998-01-01 00:00:00

  • Continuous monitoring of upper-limb activity in a free-living environment: a validation study.

    abstract::Monitoring upper-limb activity in a free-living environment is important for the evaluation of rehabilitation. This study is a validation of the Strathclyde Upper-Limb Activity Monitor (SULAM) which records the vertical movement and position of each wrist, and assesses bimanual movement. Agreement between the SULAM an...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-007-0233-7

    authors: Vega-Gonzalez A,Bain BJ,Dall PM,Granat MH

    更新日期:2007-10-01 00:00:00

  • Fluid flow and particle transport in mechanically ventilated airways. Part II: particle transport.

    abstract::The flow mechanisms that play a role on aerosol deposition were identified and presented in a companion paper (Timothy et al. in Med Biol Eng Comput. doi: 10.1007/s11517-015-1407-3 , 2015). In the current paper, the effects of invasive conventional mechanical ventilation waveforms and endotracheal tube (ETT) on the ae...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-015-1408-2

    authors: Alzahrany M,Van Rhein T,Banerjee A,Salzman G

    更新日期:2016-07-01 00:00:00

  • Experimental and numerical investigation on soft tissue dynamic response due to turbulence-induced arterial vibration.

    abstract::Peripheral arterial occlusive disease is a serious cardiovascular disorder. The arterial occlusion leads to turbulent flow and arterial sound generation on the inner vessel wall. Stenosis-induced vibro-acoustic waves propagate through the surrounding soft tissues and reach the skin surface. In this study, the feasibil...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-019-01995-y

    authors: Salman HE,Yazicioglu Y

    更新日期:2019-08-01 00:00:00

  • Methods of dynamic spectral analysis by self-exciting autoregressive moving average models and their application to analysing biosignals.

    abstract::Dynamic methods in the spectral domain are necessary to analyse biological signals because of the frequently nonstationary character of the signals. The paper presents an adaptive procedure of fitting time-dependent ARMA models to nonstationary signals, which is suitable for on-line calculations. The properties of the...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02510536

    authors: Schack B,Bareshova E,Grieszbach G,Witte H

    更新日期:1995-05-01 00:00:00

  • Prediction of O-glycosylation sites based on multi-scale composition of amino acids and feature selection.

    abstract::Protein glycosylation is one of the most important and complex post-translational modification that provides greater proteomic diversity than any other post-translational modification. Fast and reliable computational methods to identify glycosylation sites are in great demand. Two key issues, feature encoding and feat...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-015-1268-9

    authors: Chen Y,Zhou W,Wang H,Yuan Z

    更新日期:2015-06-01 00:00:00

  • Analysis of four methods of measuring three-dimensional pelvic tilt in the lateral decubitus position.

    abstract::Proper alignment of acetabular implantation is necessary for good patient outcomes and preventing complications or additional surgeries in total hip arthroplasty (THA). Rotation of the pelvis in lateral decubitus (LD) is typically not accounted for as surgeons use the surgery table as a reference plane to align implan...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-020-02235-4

    authors: Stadnyk M,Liu T,Arezodar FF,Westover L,Carvajal Alba JA,Masson E,Beaupre L,Jaremko JL,El-Rich M

    更新日期:2020-10-01 00:00:00

  • A cepstrum analysis-based classification method for hand movement surface EMG signals.

    abstract::It is of great importance to effectively process and interpret surface electromyogram (sEMG) signals to actuate a robotic and prosthetic exoskeleton hand needed by hand amputees. In this paper, we have proposed a cepstrum analysis-based method for classification of basic hand movement sEMG signals. Cepstral analysis t...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-019-02024-8

    authors: Yavuz E,Eyupoglu C

    更新日期:2019-10-01 00:00:00

  • Robust segmentation and intelligent decision system for cerebrovascular disease.

    abstract::Segmentation and classification of low-quality and noisy ultrasound images is challenging task. In this paper, a new approach is proposed for robust segmentation and classification of carotid artery ultrasound images and consequently, detecting cerebrovascular disease. The proposed technique consists of two phases, in...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-016-1481-1

    authors: Chaudhry A,Hassan M,Khan A

    更新日期:2016-12-01 00:00:00

  • Identification of the breast boundary in mammograms using active contour models.

    abstract::A method for the identification of the breast boundary in mammograms is presented. The method can be used in the preprocessing stage of a system for computer-aided diagnosis (CAD) of breast cancer and also in the reduction of image file size in picture archiving and communication system applications. The method starte...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02344632

    authors: Ferrari RJ,Rangayyan RM,Desautels JE,Borges RA,Frère AF

    更新日期:2004-03-01 00:00:00

  • Finite element modeling of the growth plate in a detailed spine model.

    abstract::Very few computer models of the spine integrate vertebral growth plates to investigate their mechanical behavior and potential impacts on bone growth. An approach was developed to generate a finite element (FE) model of the lumbar spine and their connective tissues including the growth plate, which allowed a personali...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-007-0220-z

    authors: Sylvestre PL,Villemure I,Aubin CE

    更新日期:2007-10-01 00:00:00