Abstract:
:To describe the spatial and temporal profiles of connectivity networks and sources preceding generalized spike-and-wave discharges (SWDs) in human absence epilepsy. Nonlinear associations of MEG signals and cluster indices obtained within the framework of graph theory were determined, while source localization in the frequency domain was performed in the low frequency bands with dynamic imaging of coherent sources. The results were projected on a three-dimensional surface rendering of the brain using a semi-realistic head model and MRI images obtained for each of the five patients studied. An increase in clustering and a decrease in path length preceding SWD onset and a rhythmic pattern of increasing and decreasing connectivity were seen during SWDs. Beamforming showed a consistent appearance of a low frequency frontal cortical source prior to the first generalized spikes. This source was preceded by a low frequency occipital source. The changes in the connectivity networks with the onset of SWDs suggest a pathologically predisposed state towards synchronous seizure networks with increasing connectivity from interictal to preictal and ictal state, while the occipital and frontal low frequency early preictal sources demonstrate that SWDs are not suddenly arising but gradually build up in a dynamic network.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Gupta D,Ossenblok P,van Luijtelaar Gdoi
10.1007/s11517-011-0778-3subject
Has Abstractpub_date
2011-05-01 00:00:00pages
555-65issue
5eissn
0140-0118issn
1741-0444journal_volume
49pub_type
杂志文章abstract::Architectural distortion is a subtle abnormality in mammograms, and a source of overlooking errors by radiologists. Computer-aided diagnosis (CAD) techniques can improve the performance of radiologists in detecting masses and calcifications; however, most CAD systems have not been designed to detect architectural dist...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-006-0088-3
更新日期:2006-10-01 00:00:00
abstract::A personal computer system for electrocardiogram (ECG) ST-segment recognition is developed based on neural networks. The system consists of a preprocessor, neural networks and a recogniser. The adaptive resonance theory (ART) is employed to implement the neural networks in the system, which self-organise in response t...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02446186
更新日期:1992-01-01 00:00:00
abstract::Neurofilaments are organised into parallel bundles in axons through crossbridges formed by lateral projections of neurofilament subunits. Pure neurofilaments form gels in vitro, consisting of interconnected parallel arrays of filaments regulated by the phosphorylation level of neurofilament subunits. Neurofilament-ass...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02522486
更新日期:1998-05-01 00:00:00
abstract::The paper explains the application of a genetic algorithm (GA) to the problem of estimating parameters for a kinetic model of a biologically reacting system. It is demonstrated that the GA is a powerful tool for quantifying the kinetic parameters using kinetic data. As the operation of the GA does not depend on the fo...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02510391
更新日期:1997-01-01 00:00:00
abstract::It is acknowledged that the first heart sound S1 consists of two major, high-frequency components M1 and T1, corresponding, respectively, to the vibrations of the mitral and tricuspid valves and their surrounding tissues following valve closure in early systole. In this study, the matching pursuit (MP) method was used...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02345436
更新日期:2001-11-01 00:00:00
abstract::In recent years, several studies have been focused on the problem of nonthermal interaction between extremely low-frequency (ELF) electromagnetic fields and cell environment at membrane level. In the paper, to analyse the dynamic effects of weak static and harmonic fields on charged particles, some new considerations ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02446654
更新日期:1993-07-01 00:00:00
abstract::Nitric oxide (NO) released by endothelial cells in response to hemodynamic shear stress is a key controller molecule of the vascular functions and antiatherogenic mechanisms. Endothelial dysfunction is associated with increased cardiovascular events. Therefore, several indirect techniques have been employed to evaluat...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-008-0333-z
更新日期:2008-05-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is characterized by expiratory airflow limitation, but current diagnostic criteria only consider flow till the first second and are therefore strongly debated. We aimed to develop a data-based individualized model for flow decline and to explore the relationship between mod...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-014-1202-6
更新日期:2014-12-01 00:00:00
abstract::We investigate a new framework of surgical instrument detection based on power-varying ultrasound images with simple and efficient pixel-wise intensity processing. Without using complicated feature extraction methods, we identified the instrument with an estimated optimal power level and by comparing pixel values of v...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-017-1695-x
更新日期:2018-03-01 00:00:00
abstract::A process is described for the fabrication of silicon-based microelectrodes for neurophysiology using bonded and etched-back silicon-on-insulator (BESOI) wafers. The probe shapes are defined without high levels of boron doping in the silicon; this is considered as a step towards producing probes with active electronic...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02344773
更新日期:2000-03-01 00:00:00
abstract::Currently, simulations of the induced currents in the brain produced by transcranial magnetic stimulation (TMS) are used to elucidate the regions reached by stimuli. However, models commonly found in the literature are too general and neglect imperfections in the windings. Aiming to predict the stimulation sites in pa...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-020-02156-2
更新日期:2020-07-01 00:00:00
abstract::This article presents a stimulation control method using a uniaxial gyroscope measuring angular velocity of the shank in the sagittal plane, to control functional electrical stimulation of the triceps surae to improve push-off of stroke subjects during gait. The algorithm is triggered during each swing phase of gait w...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-009-0539-8
更新日期:2009-11-01 00:00:00
abstract::Tissue hardness is related to tissue composition, and this is often changed by disease. It is therefore of interest to measure the hardness in an objective and non-invasive way. A tactile sensor based on a vibrating piezoelectric ceramic element in a feedback loop is described. When the sensor touches an object it pro...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02513357
更新日期:1999-09-01 00:00:00
abstract::An atlas-based multimodal registration method for 2-dimension images with discrepancy structures was proposed in this paper. Atlas was utilized for complementing the discrepancy structure information in multimodal medical images. The scheme includes three steps: floating image to atlas registration, atlas to reference...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-018-1808-1
更新日期:2018-11-01 00:00:00
abstract::Fluctuation analysis has great potential to contribute to pulmonary clinical science and practice. We evaluated the relationship between asthma and the respiratory impedance recurrence period density entropy (RPDEnZrs) and the variability (SDZrs). A non-invasive and simple protocol for assessing respiratory mechanics ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-012-0957-x
更新日期:2012-12-01 00:00:00
abstract::Segmentation and classification of low-quality and noisy ultrasound images is challenging task. In this paper, a new approach is proposed for robust segmentation and classification of carotid artery ultrasound images and consequently, detecting cerebrovascular disease. The proposed technique consists of two phases, in...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-016-1481-1
更新日期:2016-12-01 00:00:00
abstract::A technique to obtain the spacing distribution of macro- and microstructures of hypercholestrolemic liver, lymphoidlucosed liver, rhinosporidium of man and ethmoidal tumour of bovine is presented. The method uses signal processing of spatially averaged spectra of ultrasonic backscattering from tissues in the frequency...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02442608
更新日期:1990-11-01 00:00:00
abstract::Even though the World Health Organization criteria's for classifying the dengue infection have been used for long time, recent studies declare that several difficulties have been faced by the clinicians to apply these criteria. Accordingly, many studies have proposed modified criteria to identify the risk in dengue pa...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-009-0561-x
更新日期:2010-03-01 00:00:00
abstract::During dialysis the ion concentrations in many body fluids change significantly. The influence of these changes on the accuracy of volume measurements with bioimpedance spectroscopy is investigated by the following procedure: Plasma ion concentrations and impedance spectra (5-500 kHz) are measured during six standard ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02534137
更新日期:1997-03-01 00:00:00
abstract::Apoptosis proteins are related to many diseases. Obtaining the subcellular localization information of apoptosis proteins is helpful to understand the mechanism of diseases and to develop new drugs. At present, the researchers mainly focus on the primary protein sequences, so there is still room for improvement in the...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-019-02045-3
更新日期:2019-12-01 00:00:00
abstract::Atrial fibrillation (AF) is the most common cardiac arrhythmia with episodes that may terminate spontaneously in the first stages of the disease. On the other hand, when the arrhythmia is not self-terminating, normal sinus rhythm (NSR) restoration use to be required to reduce the risk of stroke and improve cardiac out...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-008-0348-5
更新日期:2008-07-01 00:00:00
abstract::A hydrodynamic model for the part of the human arterial network below the renal arteries has been constructed using specially fabricated distensible tubes and a pulsatile pump to simulate an aortoiliac bypass. The experiments and the computer model indicated that no 'steal' occurred due to the insertion of the bypass ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02441802
更新日期:1993-11-01 00:00:00
abstract::The fast hybrid operator splitting (HOS) and stable uniformization (UNI) methods have been proposed to save computation cost and enhance stability for Markov chain model in cardiac cell simulations. Moreover, Chen-Chen-Luo's quadratic adaptive algorithm (CCL) combined with HOS or UNI was used to improve the tradeoff b...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-020-02220-x
更新日期:2020-09-01 00:00:00
abstract::A biomechanical analysis of the constant peak displacement and constant peak force methods of cardiopulmonary resuscitation (CPR) has revealed that optimal CC performance strongly depends on back support stiffness, CC rate, and the thoracic stiffness of the patient being resuscitated. Clinically the results presented ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-012-0963-z
更新日期:2012-12-01 00:00:00
abstract::The aim of this study was the analysis of the mechanical behaviour of a partially porous lumbar custom-made cage by means of a subject-specific finite element analysis (FEA). The cage, made of Ti6Al4V ELI alloy, was produced via electron beam melting (EBM) process and surgically implanted in a female subject, 50 years...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-019-02078-8
更新日期:2019-12-01 00:00:00
abstract::The physiological parameters of blood such as extracellular Na(+), K(+), Cl(-), pH, 2,3-DPG and ATP and the complex electrical impedance were measured using whole blood samples from 31 male donors (21 donors form the training set and ten donors were used for testing), on the 0th, 10th and 21st day of blood bank storag...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-007-0206-x
更新日期:2007-07-01 00:00:00
abstract::Musculoskeletal models have been developed to estimate internal loading on the human skeleton, which cannot directly be measured in vivo, from external measurements like kinematics and external forces. Such models of the shoulder and upper extremity have been used for a variety of purposes, ranging from understanding ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章,评审
doi:10.1007/s11517-013-1099-5
更新日期:2013-09-01 00:00:00
abstract::The aim of the study was to assess the wavelength dependence of the UV absorbance during monitoring of different compounds in the dialysate. UV absorbance was determined by using a double-beam spectrophotometer on dialysate samples taken at pre-determined times during dialysis, over a wavelength range of 180-380 nm. C...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02348430
更新日期:2003-05-01 00:00:00
abstract::Recent clinical evidence has suggested that tasks performed in kneeling or squatting postures place the knee at a higher risk for injury because loads across the knee might overload the ligaments. The objective of this study was to develop a subject-specific model of the knee that is kinematically driven to predict th...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-010-0653-7
更新日期:2010-11-01 00:00:00
abstract::Cerebral autoregulation controls cerebral blood flow under changing cerebral perfusion pressure. Standards for measurement and analysis of dynamic cerebral autoregulation (dCA) are lacking. In this study, dCA reproducibility, quantified by intraclass correlation coefficient, is evaluated for different methodological a...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-010-0706-y
更新日期:2010-12-01 00:00:00