Abstract：
:A process is described for the fabrication of silicon-based microelectrodes for neurophysiology using bonded and etched-back silicon-on-insulator (BESOI) wafers. The probe shapes are defined without high levels of boron doping in the silicon; this is considered as a step towards producing probes with active electronics integrated directly beneath the electrodes. Gold electrodes, of 4 microns by 4 microns to 50 microns by 50 microns are fabricated on shanks (cantilever beams) 6 microns thick and which taper to an area approximately 100 microns wide and 200 microns long, which are inserted into the tissue under investigation. The passive probes fabricated have been successfully employed to make acute recordings from locust peripheral nerve.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Ensell G,Banks DJ,Richards PR,Balachandran W,Ewins DJdoi
10.1007/BF02344773keywords:
subject
Has Abstractpub_date
2000-03-01 00:00:00pages
175-9issue
2eissn
0140-0118issn
1741-0444journal_volume
38pub_type
杂志文章abstract：:To explore the promising therapeutic applications of short nanosecond electric pulses, in vitro and in vivo experiments are highly required. In this paper, an exposure system based on monopole patch antenna is reported to perform in vivo experiments on newborn mice with both monopolar and bipolar nanosecond signals. A...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1547-0
更新日期：2017-07-01 00:00:00
abstract：:Chronic obstructive pulmonary disease (COPD) is characterized by expiratory airflow limitation, but current diagnostic criteria only consider flow till the first second and are therefore strongly debated. We aimed to develop a data-based individualized model for flow decline and to explore the relationship between mod...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-014-1202-6
更新日期：2014-12-01 00:00:00
abstract：:The vagus nerves convey both afferent and efferent information about autonomic activity related to cardiovascular functions. Those functions have been shown to change due to epileptic seizures, which suggests that ictal events might be detected via the vagus electroneurogram (VENG). In this study, we characterize the ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-011-0782-7
更新日期：2011-09-01 00:00:00
abstract：:This study explores the analysis of a new stent geometry from two typical stents used to treat the coronary artery disease. Two different finite element methods are applied with different boundary conditions to investigate the stenosis region. Computational fluid dynamics (CFD) models including fluid-structure interac...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1574-x
更新日期：2017-06-01 00:00:00
abstract：:A method for the identification of the breast boundary in mammograms is presented. The method can be used in the preprocessing stage of a system for computer-aided diagnosis (CAD) of breast cancer and also in the reduction of image file size in picture archiving and communication system applications. The method starte...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02344632
更新日期：2004-03-01 00:00:00
abstract：:In this study, the shape and the configuration of smooth muscle cells (SMCs) within the arterial wall are altered to investigate their influence on molecular transport across the media layer of the thoracic aorta wall. In a 2D geometry of the media layer containing SMCs, the finite-element method has been employed to ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-007-0219-5
更新日期：2007-11-01 00:00:00
abstract：:Magnetic nanoparticles for therapy and diagnosis are at the leading edge of the rapidly developing field of bionanotechnology. In this study, we have theoretically studied motion of magnetic nano- as well as micro-particles in the field of cylindrical Halbach array of permanent magnets. Magnetic flux density was model...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-010-0636-8
更新日期：2010-08-01 00:00:00
abstract：:Global field synchronization (GFS) quantifies the synchronization level of brain oscillations. The GFS method has been introduced to measure functional synchronization of EEG data in the frequency domain. GFS also detects phase interactions between EEG signals acquired from all of the electrodes. If a considerable amo...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-017-1689-8
更新日期：2018-02-01 00:00:00
abstract：:The paper describes the application of new semi-automatic segmentation software to the task of detection of anatomical structures and lesion and their three-dimensional (3D) visualisation in 23 patients with secondary progressive multiple sclerosis (MS). The purpose is to study the correlation between magnetic resonan...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02513274
更新日期：1999-01-01 00:00:00
abstract：:The accelerometer is used for mechanomyogram (MMG) recordings of muscle contractions. Although the mechanical characteristics of other MMG transducers have been determined with reference to the accelerometer, mechanical aspects of the accelerometer itself, including the weight of the transducer, have not been verified...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02344888
更新日期：2003-03-01 00:00:00
abstract：:Monitoring upper-limb activity in a free-living environment is important for the evaluation of rehabilitation. This study is a validation of the Strathclyde Upper-Limb Activity Monitor (SULAM) which records the vertical movement and position of each wrist, and assesses bimanual movement. Agreement between the SULAM an...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-007-0233-7
更新日期：2007-10-01 00:00:00
abstract：:Instantaneous backflow through central clearance of bileaflet heart valves at the instant of closure is investigated. An Edwards-Duromedics valve in the mitral position is employed to measure the transient pressures near the entrance and exit region in an in vitro flow chamber. A region surrounding the clearance is mo...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02510497
更新日期：1995-05-01 00:00:00
abstract：:Taking advantage of motion sensing technology, a quantitative assessment method for lower limbs motor function of cerebral palsy (CP) based on the gross motor function measurement (GMFM)-24 scale was explored in this study. According to the motion analysis on GMFM-24 scale, we translated the assessment problem of GMFM...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-019-02076-w
更新日期：2020-01-01 00:00:00
abstract：:Disturbed cerebrospinal fluid (CSF) dynamics are part of the pathophysiology of normal pressure hydrocephalus (NPH) and can be modified and treated with shunt surgery. This study investigated the contribution of established CSF dynamic parameters to AMP(mean), a prognostic variable defined as mean amplitude of cardiac...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-013-1110-1
更新日期：2014-01-01 00:00:00
abstract：:Measurements of the dielectric properties of healthy and atherosclerotic human artery tissues were made in the frequency range of 100 Hz-100 kHz and temperatures from 22 to 260 degrees C. The temperature dependencies of the dielectric parameters for healthy tissues reveal distinctively the temperature ranges correspon...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-007-0181-2
更新日期：2007-06-01 00:00:00
abstract：:A nonlinear prediction method for investigating the dynamic interdependence between short length time series is presented. The method is a generalization to bivariate prediction of the univariate approach based on nearest neighbor local linear approximation. Given the input and output series x and y, the relationship ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-006-0043-3
更新日期：2006-05-01 00:00:00
abstract：:Time-varying filtering techniques are applied to the problem of baseline correction by letting the cut-off frequency of a linear filter be controlled by the low-frequency properties of the ECG signal. The time-varying filter is implemented as a bank of linear low-pass filters, in which each filter has a slightly diffe...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02441986
更新日期：1993-09-01 00:00:00
abstract：:Disappointing results for total ankle replacement have been explained by poor knowledge of the mechanics of the intact and replaced joints. Dynamic simulation tools have the capacity to simulate dynamic conditions that occur in human joints. The Working Model 2D tool was used to simulate the mechanics of the intact an...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02348124
更新日期：2002-03-01 00:00:00
abstract：:Peripheral arterial occlusive disease is a serious cardiovascular disorder. The arterial occlusion leads to turbulent flow and arterial sound generation on the inner vessel wall. Stenosis-induced vibro-acoustic waves propagate through the surrounding soft tissues and reach the skin surface. In this study, the feasibil...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-019-01995-y
更新日期：2019-08-01 00:00:00
abstract：:Automatic identification of landmarks in cephalometry is very important and useful for orthognathic surgery. A computerised automatic cephalometric analysis system (CACAS), based on image processing, is presented. For an original X-ray image, median filtering and histogram equalisation are used to improve image qualit...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02345280
更新日期：2001-05-01 00:00:00
abstract：:The changes in the power spectra of single-fibre extracellular action potentials (SFEAPs) generated in an infinite anisotropic frequency-dependent volume conductor, which occurred as a result of alterations in the propagation velocity v and duration T(in) of the intracellular action potential (IAP) were analytically d...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02446167
更新日期：1992-07-01 00:00:00
abstract：:Sperm morphology, as an indicator of fertility, is a critical tool in semen analysis. In this study, a smartphone-based hybrid system that fully automates the sperm morphological analysis is introduced with the aim of eliminating unwanted human factors. Proposed hybrid system consists of two progressive steps: automat...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-019-02101-y
更新日期：2020-05-01 00:00:00
abstract：:Four ventricular fibrillation (VF) detection techniques were assessed using recordings of VF to evaluate sensitivity and VF-like recordings to evaluate specificity. The recordings were obtained from Coronary Care Unit patients. The techniques were: threshold crossing intervals (TCI); peaks in the autocorrelation funct...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02446668
更新日期：1993-03-01 00:00:00
abstract：:The scapholunate ligament stabilizes the scaphoid and lunate of the proximal row in the wrist which allows for proper force transmission with the radius and ulna. Damage to this structure degenerates into arthritis and disability. Controversy exists over the best technique to restore function and reduce pain. A three-...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-019-01971-6
更新日期：2019-07-01 00:00:00
abstract：:This study analyzes the performance of knee extension and flexion of Taekwondo and Kickboxing athletes. The power values were extracted through electromyography obtained by an isokinetic dynamometer at 60 degrees per second. These values are resulted from the square of the electromyography signal. The analysis of kick...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-010-0608-z
更新日期：2010-06-01 00:00:00
abstract：:A multichannel biopotential amplifier for simultaneous use with biomagnetic measurements in a magnetically shielded room is designed and evaluated. Particular care is taken to make the amplifier electromagnetically compatible with the biomagnetic instruments over the whole frequency spectrum, from DC to RF. The electr...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02534098
更新日期：1997-07-01 00:00:00
abstract：:In common radiography, image contrast is often limited due mainly to scattered x-rays and noise, decreasing the quantitative usefulness of x-ray images. Several scatter reduction methods based on software correction schemes have been extensively investigated in an attempt to overcome these difficulties, most of which ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-018-1893-1
更新日期：2019-02-01 00:00:00
abstract：:Thousands of patients receive human tissue grafts every year. Developments in cell and tissue engineering have also increased considerably the number of available products of human origin. France has very strict regulations, in part stimulated by problems of public health and ethics that have emerged in recent years a...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02344783
更新日期：2000-03-01 00:00:00
abstract：:Spectral analysis of heart rate variability (HRV) is a widely accepted approach for assessment of cardiac autonomic function and its relationship to numerous disorders and diseases. As a rule, the non-parametric methods for HRV spectral analysis are tested using the integral pulse frequency modulation (IPFM) model. Ho...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02345290
更新日期：2001-05-01 00:00:00
abstract：:Single-ventricle anomaly is a hereditary heart disease that is characterized by anatomical malformations. The main consequence of this malformation is desaturated blood flow, which without proper treatment increases the risk of death. The classical treatment is based on a three-stage palliative procedure which should ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1499-4
更新日期：2017-02-01 00:00:00
