Abstract：
:Disturbed cerebrospinal fluid (CSF) dynamics are part of the pathophysiology of normal pressure hydrocephalus (NPH) and can be modified and treated with shunt surgery. This study investigated the contribution of established CSF dynamic parameters to AMP(mean), a prognostic variable defined as mean amplitude of cardiac-related intracranial pressure pulsations during 10 min of lumbar constant infusion, with the aim of clarifying the physiological interpretation of the variable. AMP(mean) and CSF dynamic parameters were determined from infusion tests performed on 18 patients with suspected NPH. Using a mathematical model of CSF dynamics, an expression for AMP(mean) was derived and the influence of the different parameters was assessed. There was high correlation between modelled and measured AMP(mean) (r = 0.98, p < 0.01). Outflow resistance and three parameters relating to compliance were identified from the model. Correlation analysis of patient data confirmed the effect of the parameters on AMP(mean) (Spearman's ρ = 0.58-0.88, p < 0.05). Simulated variations of ±1 standard deviation (SD) of the parameters resulted in AMP(mean) changes of 0.6-2.9 SD, with the elastance coefficient showing the strongest influence. Parameters relating to compliance showed the largest contribution to AMP(mean), which supports the importance of the compliance aspect of CSF dynamics for the understanding of the pathophysiology of NPH.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Qvarlander S,Malm J,Eklund Adoi
10.1007/s11517-013-1110-1subject
Has Abstractpub_date
2014-01-01 00:00:00pages
75-85issue
1eissn
0140-0118issn
1741-0444journal_volume
52pub_type
杂志文章abstract：:Atrial fibrillation (AF) is the most common cardiac arrhythmia with episodes that may terminate spontaneously in the first stages of the disease. On the other hand, when the arrhythmia is not self-terminating, normal sinus rhythm (NSR) restoration use to be required to reduce the risk of stroke and improve cardiac out...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-008-0348-5
更新日期：2008-07-01 00:00:00
abstract：:An algorithm for determining the frequency and propagation time of the gastric slow wave has been designed for integration into a demand gastric pacing system. The algorithm analyses the serosal activity in both the time and frequency domains, and the results are compared to produce a conclusion only when the values a...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02344688
更新日期：2000-01-01 00:00:00
abstract：:Monitoring upper-limb activity in a free-living environment is important for the evaluation of rehabilitation. This study is a validation of the Strathclyde Upper-Limb Activity Monitor (SULAM) which records the vertical movement and position of each wrist, and assesses bimanual movement. Agreement between the SULAM an...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-007-0233-7
更新日期：2007-10-01 00:00:00
abstract：:The blood cell counting and classification ensures the evaluation and diagnosis of a number of diseases. The analysis of white blood cells (WBCs) permits us to detect the acute lymphoblastic leukemia (ALL), a type of blood cancer that causes fatality when untreated. At present, the morphological analysis of blood cell...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-020-02249-y
更新日期：2020-11-01 00:00:00
abstract：:The regulation of the coronary circulation is a complex paradigm in which many inputs that influence vasomotor tone have to be integrated to provide the coronary vasomotor adjustments to cardiac metabolism and to perfusion pressure. We hypothesized that the integration of many disparate signals that influence membrane...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-008-0329-8
更新日期：2008-05-01 00:00:00
abstract：:The mechanism of brain contusion has been investigated using a series of three-dimensional (3D) finite element analyses. A head injury model was used to simulate forward and backward rotation around the upper cervical vertebra. Intracranial pressure and shear stress responses were calculated and compared. The results ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02347044
更新日期：2000-05-01 00:00:00
abstract：:A hydrodynamic model for the part of the human arterial network below the renal arteries has been constructed using specially fabricated distensible tubes and a pulsatile pump to simulate an aortoiliac bypass. The experiments and the computer model indicated that no 'steal' occurred due to the insertion of the bypass ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02441802
更新日期：1993-11-01 00:00:00
abstract：:A new ambulatory technique for qualitative and quantitative movement analysis of the humerus is presented. 3D gyroscopes attached on the humerus were used to recognize the movement of the arm and to classify it as flexion, abduction and internal/external rotations. The method was first validated in a laboratory settin...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-009-0464-x
更新日期：2009-05-01 00:00:00
abstract：:Osteoporosis is one of the most common diseases that leads to bone fractures. Dual-energy X-ray absorptiometry is currently employed to measure the bone mineral density and to diagnose osteoporosis. Alternatively, the dielectric properties of bones are found to be influenced by bone mineral density; hence, dielectric ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章,评审
doi：10.1007/s11517-018-1887-z
更新日期：2019-01-01 00:00:00
abstract：:The effect of flow direction on the morphology of cultured bovine aortic endothelial cells is studied. Fully confluent endothelial cells cultured on glass were subjected to a fluid-imposed shear stress of 2 Pa for 20 min and 24 h using a parallel plate flow chamber. Experiments on shear flow exposure were performed fo...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02522869
更新日期：1998-01-01 00:00:00
abstract：:Neurofilaments are organised into parallel bundles in axons through crossbridges formed by lateral projections of neurofilament subunits. Pure neurofilaments form gels in vitro, consisting of interconnected parallel arrays of filaments regulated by the phosphorylation level of neurofilament subunits. Neurofilament-ass...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02522486
更新日期：1998-05-01 00:00:00
abstract：:Variations in the amplitude and period of essential and Parkinsonian tremors were studied. It was found that the variations in frequency (or period) were mostly similar to the white noise, with the standard deviation typically less than 10% of the mean, whereas the variations in amplitude were much larger, with standa...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02344710
更新日期：2004-05-01 00:00:00
abstract：:In common radiography, image contrast is often limited due mainly to scattered x-rays and noise, decreasing the quantitative usefulness of x-ray images. Several scatter reduction methods based on software correction schemes have been extensively investigated in an attempt to overcome these difficulties, most of which ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-018-1893-1
更新日期：2019-02-01 00:00:00
abstract：:Marfan syndrome (MFS) is a genetic disorder that affects connective tissue, impairing cardiovascular structures and function, such as heart valves and aorta. Thus, patients with Marfan disease have a higher risk of developing circulatory problems associated with mitral and aortic valves prolapse, manifested as dilated...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1524-7
更新日期：2017-03-01 00:00:00
abstract：:A hypothetical neuromusculoskeletal model is developed to simulate human normal walking and its modulated behaviors. A small set of neural periodic patterns drive spinal muscle synergies which in turn lead to specific pattern of muscle activation and supraspinal feedback systems maintain postural balance during walkin...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-007-0277-8
更新日期：2008-02-01 00:00:00
abstract：:In a previous paper we demonstrated that the linear portion of the pressure-velocity loop (PU-loop) corresponding to early systole could be used to calculate the local wave speed. In this paper we extend this work to show that determination of the time at which the PU-loop first deviates from linearity provides a conv...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-007-0241-7
更新日期：2007-12-01 00:00:00
abstract：:The paper describes an investigation in which it is shown that small positive voltage pulses applied to an external conductor placed against the photocathode of a photomultiplier tube can be used to switch the photocathode completely off for the duration of the pulses. This suggests that a photomultiplier tube with a ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02441486
更新日期：1989-05-01 00:00:00
abstract：:Automatic identification of landmarks in cephalometry is very important and useful for orthognathic surgery. A computerised automatic cephalometric analysis system (CACAS), based on image processing, is presented. For an original X-ray image, median filtering and histogram equalisation are used to improve image qualit...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02345280
更新日期：2001-05-01 00:00:00
abstract：:A mathematical model has been developed to facilitate indirect measurements of difficult to measure variables of the human energy metabolism on a daily basis. The model performs recursive system identification of the parameters of the metabolic model of the human energy metabolism using the law of conservation of ener...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1552-3
更新日期：2017-05-01 00:00:00
abstract：:In the field of sports biomechanics and rehabilitation engineering, the possibility of computing, in real time, the angular displacements and derivatives of human joints, from a video of motion sequences, represents an appealing goal. In particular, applications of biofeedback protocols in rehabilitation can benefit f...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02344878
更新日期：2003-03-01 00:00:00
abstract：:Dengue fever detection and classification have a vital role due to the recent outbreaks of different kinds of dengue fever. Recently, the advancement in the microarray technology can be employed for such classification process. Several studies have established that the gene selection phase takes a significant role in ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-017-1722-y
更新日期：2018-04-01 00:00:00
abstract：:Artifacts cause distortion and fuzziness in electroencephalographic (EEG) signal and hamper EEG analysis, so it is necessary to remove them prior to the analysis. Particularly, artifact removal becomes a critical issue in experimental protocols with significant inherent recording noise, such as mobile EEG recordings a...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-017-1620-3
更新日期：2017-09-01 00:00:00
abstract：:Biological variation in branching patterns is likely to affect perfusion of tissue. To assess the fundamental consequences of branching characteristics, 50 stochastic asymmetrical coronary trees and one non-stochastic symmetrical branching tree were generated. In the stochastic trees, area growth, A, at branching poin...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-006-0139-9
更新日期：2007-01-01 00:00:00
abstract：:Electromyography (EMG) in a bio-driven system is used as a control signal, for driving a hand prosthesis or other wearable assistive devices. Processing to get informative drive signals involves three main modules: preprocessing, dimensionality reduction, and classification. This paper proposes a system for classifyin...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-018-1857-5
更新日期：2018-12-01 00:00:00
abstract：:This review is a commentary on recent, altered perspectives about biomedical engineering and its role in medicine. It is argued that, rather than being a peripheral specialty, medical engineering and engineering principles in general have a direct application to biochemical medicine and cell biology. A brief descripti...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章,评审
doi：10.1007/BF02446170
更新日期：1992-07-01 00:00:00
abstract：:Breast cancer is the most common cancer among women globally, and the number of young women diagnosed with this disease is gradually increasing over the years. Mammography is the current gold-standard technique although it is known to be less sensitive in detecting tumors in woman with dense breast tissue. Detecting a...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-015-1403-7
更新日期：2016-09-01 00:00:00
abstract：:Sino-aortic denervation (SAD) is employed in cats to evaluate the baroreflex influence on blood pressure (BP) and pulse interval (PI) spectral components from 0.00008 to 0.9 Hz as assessed by FFT wide-band spectra and their 1/f modelling; and the linear coupling between BP and PI and between systolic and diastolic BP ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02520018
更新日期：1996-03-01 00:00:00
abstract：:Detailed finite element (FE) models are used as promising tools to investigate traumatic brain injuries, although their accuracy is strongly dependent on the characterization of the mechanical behaviors of the different anatomic structures in the brain. In some cases, when the FE models require finer spatial resolutio...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-018-1891-3
更新日期：2019-03-01 00:00:00
abstract：:A method for extrapolating the extracellular water (ECW) resistance from wrist-ankle resistance at 50 kHz (R (50)) is proposed in this paper, in order to enable 50 kHz impedancemeters to use the BIS-Hanai equation for determination of ECW. Values of R (50) and the ECW resistance extrapolated at zero frequency R (e) we...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-008-0394-z
更新日期：2009-01-01 00:00:00
abstract：:Instantaneous backflow through central clearance of bileaflet heart valves at the instant of closure is investigated. An Edwards-Duromedics valve in the mitral position is employed to measure the transient pressures near the entrance and exit region in an in vitro flow chamber. A region surrounding the clearance is mo...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02510497
更新日期：1995-05-01 00:00:00
