Opportunities for the cellular approach in biomedical engineering.

Abstract:

:This review is a commentary on recent, altered perspectives about biomedical engineering and its role in medicine. It is argued that, rather than being a peripheral specialty, medical engineering and engineering principles in general have a direct application to biochemical medicine and cell biology. A brief description is given of the cell as a compartmentalised reactor system, and the ways in which it is possible to replace lost or aberrant cell function. Specific topics are then covered to illustrate the general thesis. These are: polymers for cell mimicry, cell-surface interactions, biomolecule transport, cell transport phenomena, cell signalling, harnessing of cells for therapy and microbial interactions. These disparate subject areas have a common thread of interest for the biomedical engineer, and are presented here in a way which highlights key points of relevance for engineering. Though necessarily brief, the various descriptions in this review provide a film indication that a rigorous approach to the assessment, modelling and use of cells along sound engineering lines is vital for the future. It is concluded that, without this approach, our understanding of cell biology will remain semiquantitative and semiempirical.

journal_name

Med Biol Eng Comput

authors

Vadgama P

doi

10.1007/BF02446170

keywords:

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

CE2-7

issue

4

eissn

0140-0118

issn

1741-0444

journal_volume

30

pub_type

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