Abstract:
:Detailed finite element (FE) models are used as promising tools to investigate traumatic brain injuries, although their accuracy is strongly dependent on the characterization of the mechanical behaviors of the different anatomic structures in the brain. In some cases, when the FE models require finer spatial resolution, the heterogeneous and anisotropic corona radiata cannot be taken as a homogeneous whole body. In this work, indentation experiments were conducted on the anterior, superior, and posterior regions of the corona radiata in the sagittal plane. To determine the parameters available for computational modeling purposes, a linear viscoelastic model using the Boltzmann hereditary integral was fitted to the force-time data of the three regions. In the indentation tests, the superior region appeared to be the stiffest, while no significant differences were observed between the anterior and posterior regions until the viscoelastic tissue reached equilibrium. During the period of relaxation, statistical comparisons among the different regions indicated significant differences between the superior and anterior regions, and between the superior and posterior regions. This work complements existing investigations into the anatomic heterogeneity of the brain, and contributes toward improving the spatial resolution of future computational models. Graphical abstract Relaxation functions of different regions based on the Prony series parameters and the multiregional Kolmogorov-Smirnov comparisons (*p < 0.017). The anisotropy and interregional differences of the corona radiata observed in this study are supplementary to the previous explorations of the mechanical properties of different brain anatomic structures.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Pan C,Chen F,Zhou J,Li X,Zhao F,Zhang Xdoi
10.1007/s11517-018-1891-3subject
Has Abstractpub_date
2019-03-01 00:00:00pages
615-622issue
3eissn
0140-0118issn
1741-0444pii
10.1007/s11517-018-1891-3journal_volume
57pub_type
杂志文章abstract::A computer controlled mechanical lung model has been developed for testing lung function equipment, validation of computer programs and simulation of impaired pulmonary mechanics. The construction, function and some applications are described. The physical model is constructed from two bellows and a pipe system repres...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02523009
更新日期:1995-11-01 00:00:00
abstract::Implantable cardioverter defibrillators (ICDs) can store intracardiac electrograms (EGMs) in sinus rhythm (SR), at the onset of spontaneous ventricular tachyarrhythmias (VT) or during their course. This allows the investigation of unknown features of the heart electrical activity associated with different cardiac rhyt...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-005-0014-0
更新日期:2006-03-01 00:00:00
abstract::The heart rate variability (HRV) is an indicator of the subject homeostasis alterations. For a healthy individual, the HRV shows a nonlinear behavior, thus requiring a nonlinear approach to provide additional information about HRV dynamics. In this work, the nonlinear techniques, central tendency measure (CTM) and sec...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-015-1390-8
更新日期:2015-11-01 00:00:00
abstract::Primary stability of refixated fractures in case of shoulder hemiarthroplasty is a prerequisite to restore physiological glenohumeral joint function. Clinical observations often show a secondary dislocation and subsequent resorption of the bony anchor points like the greater and lesser tuberosity at the rotator cuff t...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-009-0483-7
更新日期:2009-05-01 00:00:00
abstract::Osteoporosis is one of the most common diseases that leads to bone fractures. Dual-energy X-ray absorptiometry is currently employed to measure the bone mineral density and to diagnose osteoporosis. Alternatively, the dielectric properties of bones are found to be influenced by bone mineral density; hence, dielectric ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章,评审
doi:10.1007/s11517-018-1887-z
更新日期:2019-01-01 00:00:00
abstract::Conduct disorder (CD) is an important mental health problem in childhood and adolescence. There is presently a trend of revealing neural mechanisms using measures of brain networks. This study goes further by presenting a classification scheme to distinguish subjects with CD from typically developing healthy subjects ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-020-02215-8
更新日期:2020-09-01 00:00:00
abstract::Left ventricular assist device (LVAD) support unloads left ventricular (LV) pressure and volume and decreases wall stress. This study investigated the effect of systematic LVAD unloading on the 3-dimensional myocardial wall stress by employing finite element models containing layered fiber structure, active contractil...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-014-1205-3
更新日期:2014-12-01 00:00:00
abstract::Biomechanical models used to estimate joint loads often predict that antagonistic muscles are inactive or underestimate their contributions [3, 5]. This can result in systematic underestimation of muscle force predictions and joint contact forces. To test the feasibility of employing an empirical co-activation ratio t...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-013-1081-2
更新日期:2014-03-01 00:00:00
abstract::The propagation of waves in the arteries is generally described using Fourier analysis in terms of periodic wavetrains formed by the superposition of a mean value and sinusoidal waves at the fundamental frequency (defined by the heart rate) and its harmonics. There is, however, an alternative way to describe waves in ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-008-0403-2
更新日期:2009-02-01 00:00:00
abstract::A biomechanical analysis of the constant peak displacement and constant peak force methods of cardiopulmonary resuscitation (CPR) has revealed that optimal CC performance strongly depends on back support stiffness, CC rate, and the thoracic stiffness of the patient being resuscitated. Clinically the results presented ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-012-0963-z
更新日期:2012-12-01 00:00:00
abstract::Precise segmentation of stroke lesions from brain magnetic resonance (MR) images poses a challenging task in automated diagnosis. In this paper, we proposed a new method called watershed-based lesion segmentation algorithm (WLSA), which is a novel intensity-based segmentation technique used to delineate infarct lesion...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-017-1726-7
更新日期:2018-05-01 00:00:00
abstract::A system, to collect, analyse and display biological data, is developed using IBM PC AT compatibles (PCs) or CED1401/1609 devices networked to a VAX environment. It can be operated in three separate modes: using the CED/IEEE/VAX network; using the PC/Ethernet/VAX network; as a standalone PC. The original system compri...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02446881
更新日期:1993-01-01 00:00:00
abstract::A computer-assisted human peripheral blood leukocyte image classification method based on Siamese network is proposed. Firstly, a Siamese network with two identical convolutional neural network (CNN) sub-networks and a logistic regression for leukocyte five classification is designed, which can learn not only distingu...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-020-02180-2
更新日期:2020-07-01 00:00:00
abstract::In a previous paper we demonstrated that the linear portion of the pressure-velocity loop (PU-loop) corresponding to early systole could be used to calculate the local wave speed. In this paper we extend this work to show that determination of the time at which the PU-loop first deviates from linearity provides a conv...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-007-0241-7
更新日期:2007-12-01 00:00:00
abstract::A continuous cardiac output monitoring system has been developed in the laboratory to allow the real-time measurement of the cardiac output. This form of continuous cardiac output measurement allows the doctor to view the beat-to-beat cardiac output and can be employed to measure artery constrictions as well. The sens...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02345272
更新日期:2001-01-01 00:00:00
abstract::Sealing resistance is highly significant with respect to the electrical neuron-electrode contact because it decreases the stimulation threshold of neurons cultured on a planar micro-electrode array. A method is proposed for measurement of the sealing resistance using impedance spectroscopy. The effect of the sealing r...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02524436
更新日期:1998-09-01 00:00:00
abstract::A technique is proposed that allows automatic decomposition of electromyographic (EMG) signals into their constituent motor unit action potential trains (MUAPTs). A specific iterative algorithm with a classification method using fuzzy-logic techniques was developed. The proposed classification method takes into accoun...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02349972
更新日期:2003-11-01 00:00:00
abstract::Stroke survivors are more prone to developing cognitive impairment and dementia. Dementia detection is a challenge for supporting personalized healthcare. This study analyzes the electroencephalogram (EEG) background activity of 5 vascular dementia (VaD) patients, 15 stroke-related patients with mild cognitive impairm...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-017-1734-7
更新日期:2018-01-01 00:00:00
abstract::Whether Fourier transform infra-red spectroscopy with an attenuated total reflection prism could be applied for noninvasive glucose measurement through oral mucosa was evaluated. As a result, the same absorbance peak at 1033 cm-1 as in glucose aqueous solution was found in the absorbance spectra through mucous membran...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02446645
更新日期:1993-07-01 00:00:00
abstract::The physiological parameters of blood such as extracellular Na(+), K(+), Cl(-), pH, 2,3-DPG and ATP and the complex electrical impedance were measured using whole blood samples from 31 male donors (21 donors form the training set and ten donors were used for testing), on the 0th, 10th and 21st day of blood bank storag...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-007-0206-x
更新日期:2007-07-01 00:00:00
abstract::Spectral analysis of heart rate variability (HRV) is an accepted method for assessment of cardiac autonomic function and its relationship to numerous disorders and diseases. Various non-parametric methods for HRV estimation have been developed. The spectrum of counts, the instantaneous heart rate spectrum and the inte...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02524426
更新日期:1998-09-01 00:00:00
abstract::Spectral analysis of heart rate variability (HRV) is a widely accepted approach for assessment of cardiac autonomic function and its relationship to numerous disorders and diseases. As a rule, the non-parametric methods for HRV spectral analysis are tested using the integral pulse frequency modulation (IPFM) model. Ho...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02345290
更新日期:2001-05-01 00:00:00
abstract::The flow mechanisms that play a role on aerosol deposition were identified and presented in a companion paper (Timothy et al. in Med Biol Eng Comput. doi: 10.1007/s11517-015-1407-3 , 2015). In the current paper, the effects of invasive conventional mechanical ventilation waveforms and endotracheal tube (ETT) on the ae...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-015-1408-2
更新日期:2016-07-01 00:00:00
abstract::With the advent of biomedical imaging technology, the number of captured and stored biomedical images is rapidly increasing day by day in hospitals, imaging laboratories and biomedical institutions. Therefore, more robust biomedical image analysis technology is needed to meet the requirement of the diagnosis and class...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-018-1819-y
更新日期:2019-01-01 00:00:00
abstract::This article presents model predictive controllers (MPCs) and multi-parametric model-based controllers for delivery of anaesthetic agents. The MPC can take into account constraints on drug delivery rates and state of the patient but requires solving an optimization problem at regular time intervals. The multi-parametr...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-010-0604-3
更新日期:2010-06-01 00:00:00
abstract::Deep brain stimulation (DBS) surgery is extensively used in the treatment of movement disorders. Nevertheless, methods to evaluate the clinical response during intraoperative stimulation tests to identify the optimal position for the implantation of the chronic DBS lead remain subjective. In this paper, we describe a ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-016-1559-9
更新日期:2017-05-01 00:00:00
abstract::The study and applications of in vivo skin optics have been openly documented as early as the year 1954, or possibly earlier. To date, challenges in analyzing the complexities of this field remain, with wide scopes requiring more scrutiny. Recent advances in spectroscopic research and multivariate analytics allow a cl...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章,评审
doi:10.1007/s11517-019-02077-9
更新日期:2020-06-01 00:00:00
abstract::The aim of this study was to design a new approach for the acquisition of regional radial strain from the middle portion of the interventricular septum. We designed and wrote a program in Matlab (computer-assisted method) for use on a personal computer so that the septum thickness throughout the cardiac cycle could be...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-007-0222-x
更新日期:2007-09-01 00:00:00
abstract::A previously proposed finite element model that considers geometric and material nonlinearities and the free boundary problems that occur at the catheter tip and in the annular zone around the lateral surface of the catheter was revised and was used to fit a power-law formula to predict backflow length during infusion...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-014-1187-1
更新日期:2014-10-01 00:00:00
abstract::A system composed of a functional continuous magnetic stimulator (FCMS) and a saddle-type coil has been developed for non-invasive treatment of urinary incontinence, especially stress incontinence and urge incontinence. The FCMS conditions were as follows: 2 kW maximum electrical power consumption, 800 V maximum capac...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02518872
更新日期:1998-11-01 00:00:00