Abstract：
:Calcific aortic valve disease (CAVD) is characterized by calcification accumulation and thickening of the aortic valve cusps, leading to stenosis. The importance of fluid flow shear stress in the initiation and regulation of CAVD progression is well known and has been studied recently using fluid-structure interaction (FSI) models. While cusp calcifications are three-dimensional (3D) masses, previously published FSI models have represented them as either stiffened or thickened two-dimensional (2D) cusps. This study investigates the hemodynamic effect of these calcifications employing FSI models using 3D patient-specific calcification masses. A new reverse calcification technique (RCT) is used for modeling different stages of calcification growth based on the spatial distribution of calcification density. The RCT is applied to generate the 3D calcification deposits reconstructed from a patient-specific CT scans. Our results showed that consideration of 3D calcification deposits led to both higher fluid shear stresses and unique fluid shear stress distribution on the aortic side of the cusps that may have an impact on the calcification growth rate. However, the flow did not seem to affect the geometry of the calcification during the growth phase.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Halevi R,Hamdan A,Marom G,Lavon K,Ben-Zekry S,Raanani E,Bluestein D,Haj-Ali Rdoi
10.1007/s11517-016-1458-0subject
Has Abstractpub_date
2016-11-01 00:00:00pages
1683-1694issue
11eissn
0140-0118issn
1741-0444pii
10.1007/s11517-016-1458-0journal_volume
54pub_type
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