Abstract：
:Performance evaluations of ion-selective field-effect transistors (ISFETs) have been carried out using both quality-control materials and whole arterial blood samples. Comparison of the results from these evaluations suggests that the whole blood evaluation may be more useful when assessing the value of particular sensors for clinical applications. The effect of outliers on the imprecision estimates is demonstrated for ISFETs and ISEs, both graphically and in the calculation of the estimates with and without the outliers present. Estimates of constant and proportional bias, against an alternative sensor, determined from the intercept and slope of the linear regression vary according to the regression method used. The bias estimates obtained for the K + ISFET against the Radiometer KNA1 using ordinary least squares regression are compared with the Deming/Mandel method and the three-group resistant line method of Tukey. The Thorn EMI ISFETs are demonstrated to have acceptable imprecision and only a small bias compared with direct ISE instruments for whole blood assay and can be considered suitable for incorporation into clinical instrumentation.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Thompson JMdoi
10.1007/BF02442678subject
Has Abstractpub_date
1990-05-01 00:00:00pages
B29-33issue
3eissn
0140-0118issn
1741-0444journal_volume
28pub_type
杂志文章abstract：:The Chinese herb radix Salviae miltiorrhizae (RSM) is used in traditional Chinese medicine as a treatment for cardiovascular and cerebrovascular diseases. Several components of the plant extract from salvia mitorrhiza bunge have been determined previously, one of which is protocatechuic acid (PAC). It has been found, ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02345308
更新日期：2002-11-01 00:00:00
abstract：:Multi-scale modeling of the musculoskeletal system plays an essential role in the deep understanding of complex mechanisms underlying the biological phenomena and processes such as bone metabolic processes. Current multi-scale models suffer from the isolation of sub-models at each anatomical scale. The objective of th...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章,评审
doi：10.1007/s11517-016-1572-z
更新日期：2017-06-01 00:00:00
abstract：:Dislocation is a serious potential complication of total hip replacement. Previous studies have proposed a newly developed total hip structure that meets the required oscillation angle of 120°, for which the chamfer on the acetabular liner rim was designed to enable the neck to impinge on the chamfer over a large area...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-017-1673-3
更新日期：2018-01-01 00:00:00
abstract：:We introduce a novel method for an automatic classification of subjects to those with or without neuromuscular disorders. This method is based on multiscale entropy of recorded surface electromyograms (sEMGs) and support vector classification. The method was evaluated on a single-channel experimental sEMGs recorded fr...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-010-0629-7
更新日期：2010-08-01 00:00:00
abstract：:Many successful models to describe the biomechanical characteristics of planar biological soft tissues are based on strain energy function. However, the parameters in these models are determined by biaxial extension test, which might be difficult to exercise for certain types of soft tissue. This study presents a new ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-013-1098-6
更新日期：2013-10-01 00:00:00
abstract：:It is of great importance to effectively process and interpret surface electromyogram (sEMG) signals to actuate a robotic and prosthetic exoskeleton hand needed by hand amputees. In this paper, we have proposed a cepstrum analysis-based method for classification of basic hand movement sEMG signals. Cepstral analysis t...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-019-02024-8
更新日期：2019-10-01 00:00:00
abstract：:The authors have applied estimation theory to the problem of determining primary current distributions from measured neuromagnetic fields. In this procedure, essentially nothing is assumed about the source currents, except that they are spatially restricted to a certain region. Simulation experiments show that the res...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02512476
更新日期：1994-01-01 00:00:00
abstract：:We have successfully developed a multiscale acoustic-resolution photoacoustic tomography system in a single imaging platform. By switching between ultrasound transducers (center frequencies 5 and 40 MHz) and optical condensers, we have photoacoustically imaged microvasculatures of small animals in vivo at different sc...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-014-1182-6
更新日期：2016-03-01 00:00:00
abstract：:Past decades witnessed the expansion of linear signal processing methods in numerous biomedical applications. However, the nonlinear behavior of biomedical signals revived the interest in nonlinear signal processing methods such as higher-order statistics, in particular higher-order cumulants (HOC). In this paper, HOC...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-015-1394-4
更新日期：2015-11-01 00:00:00
abstract：:Instrumentation to measure accurately the stresses at the interface of a residual limb and prosthetic socket has a strong potential for use in prosthetic treatment. As a tool in the clinical setting, the device would allow a clinician to identify sites of excessive loading, information which could then be combined wit...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章,评审
doi：10.1007/BF02522507
更新日期：1995-07-01 00:00:00
abstract：:Nitric oxide (NO) released by endothelial cells in response to hemodynamic shear stress is a key controller molecule of the vascular functions and antiatherogenic mechanisms. Endothelial dysfunction is associated with increased cardiovascular events. Therefore, several indirect techniques have been employed to evaluat...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-008-0333-z
更新日期：2008-05-01 00:00:00
abstract：:Even though the World Health Organization criteria's for classifying the dengue infection have been used for long time, recent studies declare that several difficulties have been faced by the clinicians to apply these criteria. Accordingly, many studies have proposed modified criteria to identify the risk in dengue pa...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-009-0561-x
更新日期：2010-03-01 00:00:00
abstract：:In acute experiments the sciatic nerve of the rat is electrically stimulated to induce fatigue in the medial Gastrocnemius muscle. Fatigue tests are carried out using intermittent stimulation of different compartments (sequential) or a single compartment (synchronous) of the sciatic nerve. The activation of different ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02530036
更新日期：1997-05-01 00:00:00
abstract：:In this study, we present finite element analysis models to calculate the increase in intrathoracic volume of pectus excavatum patients after the Nuss procedure. One virtue of our approach is that the measurement of the intrathoracic volume has no time difference and is not affected by postoperative pain, which cannot...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-009-0570-9
更新日期：2010-02-01 00:00:00
abstract：:The development of an active implantable device for measuring electrocardiogram (ECG) is presented. The study is a part of a project which aims at developing implantable ECG instrumentation with wireless data and power transfer ( http://www.ele.tut.fi/tule ). The developed implant presented here has all the measuremen...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章,评审
doi：10.1007/s11517-007-0264-0
更新日期：2007-12-01 00:00:00
abstract：:Spectral analysis of heart rate variability (HRV) is an accepted method for assessment of cardiac autonomic function and its relationship to numerous disorders and diseases. Various non-parametric methods for HRV estimation have been developed. The spectrum of counts, the instantaneous heart rate spectrum and the inte...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02524426
更新日期：1998-09-01 00:00:00
abstract：:Sino-aortic denervation (SAD) is employed in cats to evaluate the baroreflex influence on blood pressure (BP) and pulse interval (PI) spectral components from 0.00008 to 0.9 Hz as assessed by FFT wide-band spectra and their 1/f modelling; and the linear coupling between BP and PI and between systolic and diastolic BP ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02520018
更新日期：1996-03-01 00:00:00
abstract：:Density assessment and lesion localization in breast MRI require accurate segmentation of breast tissues. A fast, computerized algorithm for volumetric breast segmentation, suitable for multi-centre data, has been developed, employing 3D bias-corrected fuzzy c-means clustering and morphological operations. The full br...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1484-y
更新日期：2017-01-01 00:00:00
abstract：:This study describes a new method for analyzing microcirculatory videos. It introduces algorithms for quantitative assessment of vessel length, diameter, the functional microcirculatory density distribution and red blood-cell (RBC) velocity in individual vessels as well as its distribution. The technique was validated...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-008-0349-4
更新日期：2008-07-01 00:00:00
abstract：:This study examined the electroencephalogram functional connectivity (coherence) and effective connectivity (flow of information) of selected brain regions during three different attentive states: awake, meditation and drowsiness. For the estimation of functional connectivity (coherence), Welch and minimum variance di...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-015-1272-0
更新日期：2015-07-01 00:00:00
abstract：:Abnormal localization of immature precursors (ALIP) aggregating and clustering in bone marrow biopsy appears earlier than that of bone marrow smears in detection of the relapse of acute myelocytic leukemia (AML). But traditional manual ALIP recognition has many shortcomings such as prone to false alarms, neglect of di...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-014-1223-1
更新日期：2015-03-01 00:00:00
abstract：:The boundary-element method (BEM) is widely used for electrocardiogram (ECG) simulation. Its major disadvantage is its perceived inability to deal with the anisotropic electric conductivity of the myocardial interstitium, which led researchers to represent only intracellular anisotropy or neglect anisotropy altogether...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-009-0472-x
更新日期：2009-07-01 00:00:00
abstract：:Chronic obstructive pulmonary disease (COPD) is characterized by expiratory airflow limitation, but current diagnostic criteria only consider flow till the first second and are therefore strongly debated. We aimed to develop a data-based individualized model for flow decline and to explore the relationship between mod...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-014-1202-6
更新日期：2014-12-01 00:00:00
abstract：:Electromyography (EMG) in a bio-driven system is used as a control signal, for driving a hand prosthesis or other wearable assistive devices. Processing to get informative drive signals involves three main modules: preprocessing, dimensionality reduction, and classification. This paper proposes a system for classifyin...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-018-1857-5
更新日期：2018-12-01 00:00:00
abstract：:To make picture archiving and communication systems (PACS) a practical reality for small-scale structures, it appears necessary to build a network that integrates and optimises production management, analysis and storage of images, and to include the ability to communicate with other similar remote structures. To solv...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02458046
更新日期：1993-05-01 00:00:00
abstract：:A method for making a current-ratio map to determine the ischaemic area of angina pectoris (AP) patients has been developed. This method uses a current-arrow map calculated using a ORS wave from 64-channel magnetocardiogram (MCG) signals. The current-ratio map can be calculated from the ratio of an exercise-induced cu...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02345263
更新日期：2001-01-01 00:00:00
abstract：:A building block-based software framework was developed to simulate electrophysiological networks. The synaptic potentials generated during neurotransmission were simulated in an existing discrete bidomain model of smooth muscle, using cubic, three-dimensional grids of varying sizes. The model is automatically derived...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02345322
更新日期：2003-09-01 00:00:00
abstract：:Nowadays, acoustic emission (AE) has its applications in various areas, including mechanical, civil, underwater acoustics, and biomedical engineering. It is a non-destructive evaluation (NDE) and a non-intrusive method to detect active damage mechanisms such as crack growth, delamination, and processes such as frictio...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章,评审
doi：10.1007/s11517-020-02202-z
更新日期：2020-08-01 00:00:00
abstract：:The problem of excess cerebrospinal fluid in the brain (hydrocephalus) is generally managed using a passive pressure or flow regulated mechanical shunt. Despite the success of such devices, they have been plagued with a number of problems. It is desirable to have a shunt valve that responds dynamically to the changing...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-010-0716-9
更新日期：2011-01-01 00:00:00
abstract：:The mechanism of brain contusion has been investigated using a series of three-dimensional (3D) finite element analyses. A head injury model was used to simulate forward and backward rotation around the upper cervical vertebra. Intracranial pressure and shear stress responses were calculated and compared. The results ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02347044
更新日期：2000-05-01 00:00:00
