Abstract：
:This study describes a new method for analyzing microcirculatory videos. It introduces algorithms for quantitative assessment of vessel length, diameter, the functional microcirculatory density distribution and red blood-cell (RBC) velocity in individual vessels as well as its distribution. The technique was validated and compared to commercial software. The method was applied to the sublingual microcirculation in a healthy volunteer and in a patient during cardiac surgery. Analysis time was reduced from hours to minutes compared to previous methods requiring manual vessel identification. Vessel diameter was detected with high accuracy (>80%, d > 3 pixels). Capillary length was estimated within 5 pixels accuracy. Velocity estimation was very accurate (>95%) in the range [2.5, 1,000] pixels/s. RBC velocity was reduced by 70% during the first 10 s of cardiac luxation. The present method has been shown to be fast and accurate and provides increased insight into the functional properties of the microcirculation.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Dobbe JG,Streekstra GJ,Atasever B,van Zijderveld R,Ince Cdoi
10.1007/s11517-008-0349-4subject
Has Abstractpub_date
2008-07-01 00:00:00pages
659-70issue
7eissn
0140-0118issn
1741-0444journal_volume
46pub_type
杂志文章abstract：:Several 3D reconstruction techniques deriving from stereoradiographic DLT have been presented during the last 15 years, but these techniques have usually been limited in accuracy because of the small number of corresponding anatomical landmarks identified on both radiographs. A new technique has recently been proposed...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02344797
更新日期：2001-03-01 00:00:00
abstract：:Electromyography (EMG) in a bio-driven system is used as a control signal, for driving a hand prosthesis or other wearable assistive devices. Processing to get informative drive signals involves three main modules: preprocessing, dimensionality reduction, and classification. This paper proposes a system for classifyin...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-018-1857-5
更新日期：2018-12-01 00:00:00
abstract：:Neurofilaments are organised into parallel bundles in axons through crossbridges formed by lateral projections of neurofilament subunits. Pure neurofilaments form gels in vitro, consisting of interconnected parallel arrays of filaments regulated by the phosphorylation level of neurofilament subunits. Neurofilament-ass...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02522486
更新日期：1998-05-01 00:00:00
abstract：:Classification of cancerous genes from microarray data is an important research area in bioinformatics. Large amount of microarray data are available, but it is very costly to label them. This paper proposes an active learning model, a semi-supervised classification approach, to label the microarray data using which p...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-020-02238-1
更新日期：2020-10-01 00:00:00
abstract：:While matrix remodeling plays a key role in vascular physiology and pathology, the underlying mechanisms have remained incompletely understood. We studied the remodeling of collagen matrices by individual vascular smooth muscle cells (SMCs), clusters and monolayers. In addition, we focused on the contribution of trans...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-012-0916-6
更新日期：2012-07-01 00:00:00
abstract：:The purpose of the study was to explore the application of artificial neural network model in the auxiliary diagnosis of lung cancer and compare the effects of back-propagation (BP) neural network with Fisher discrimination model for lung cancer screening by the combined detections of four biomarkers of p16, RASSF1A a...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1585-7
更新日期：2017-08-01 00:00:00
abstract：:This study examined the electroencephalogram functional connectivity (coherence) and effective connectivity (flow of information) of selected brain regions during three different attentive states: awake, meditation and drowsiness. For the estimation of functional connectivity (coherence), Welch and minimum variance di...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-015-1272-0
更新日期：2015-07-01 00:00:00
abstract：:Architectural distortion is a subtle abnormality in mammograms, and a source of overlooking errors by radiologists. Computer-aided diagnosis (CAD) techniques can improve the performance of radiologists in detecting masses and calcifications; however, most CAD systems have not been designed to detect architectural dist...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-006-0088-3
更新日期：2006-10-01 00:00:00
abstract：:Fluctuation analysis has great potential to contribute to pulmonary clinical science and practice. We evaluated the relationship between asthma and the respiratory impedance recurrence period density entropy (RPDEnZrs) and the variability (SDZrs). A non-invasive and simple protocol for assessing respiratory mechanics ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-012-0957-x
更新日期：2012-12-01 00:00:00
abstract：:A computer-assisted human peripheral blood leukocyte image classification method based on Siamese network is proposed. Firstly, a Siamese network with two identical convolutional neural network (CNN) sub-networks and a logistic regression for leukocyte five classification is designed, which can learn not only distingu...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-020-02180-2
更新日期：2020-07-01 00:00:00
abstract：:Whether Fourier transform infra-red spectroscopy with an attenuated total reflection prism could be applied for noninvasive glucose measurement through oral mucosa was evaluated. As a result, the same absorbance peak at 1033 cm-1 as in glucose aqueous solution was found in the absorbance spectra through mucous membran...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02446645
更新日期：1993-07-01 00:00:00
abstract：:A computer controlled mechanical lung model has been developed for testing lung function equipment, validation of computer programs and simulation of impaired pulmonary mechanics. The construction, function and some applications are described. The physical model is constructed from two bellows and a pipe system repres...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02523009
更新日期：1995-11-01 00:00:00
abstract：:This review is a commentary on recent, altered perspectives about biomedical engineering and its role in medicine. It is argued that, rather than being a peripheral specialty, medical engineering and engineering principles in general have a direct application to biochemical medicine and cell biology. A brief descripti...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章,评审
doi：10.1007/BF02446170
更新日期：1992-07-01 00:00:00
abstract：:The performance of the stimulation coil in a magnetic nerve stimulator can be improved by attaching a ferromagnetic structure to the coil. This reduces heat generation at the coil and increases magnetic field strength for a given unit of current. Some technical aspects of the design of a stimulation coil with a ferrom...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02345312
更新日期：2003-09-01 00:00:00
abstract：:Marfan syndrome (MFS) is a genetic disorder that affects connective tissue, impairing cardiovascular structures and function, such as heart valves and aorta. Thus, patients with Marfan disease have a higher risk of developing circulatory problems associated with mitral and aortic valves prolapse, manifested as dilated...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1524-7
更新日期：2017-03-01 00:00:00
abstract：:The study focuses on the problems of dimensionality reduction by means of principal component analysis (PCA) in the context of single-trial EEG data classification (i.e. discriminating between imagined left- and right-hand movement). The principal components with the highest variance, however, do not necessarily carry...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02522476
更新日期：1998-05-01 00:00:00
abstract：:An automatic power-generating system (AGS) which converts kinetic energy into electric energy for quartz watches was tested as a power source for implantable cardiac pacemakers. An automatic power-generating mechanism and a capacitor (0.33 F) were removed from a quartz watch (SEIKO) and encapsulated in a polyvinyl cas...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02513315
更新日期：1999-05-01 00:00:00
abstract：:The purpose of this study was to evaluate the effect of increased blood flow on angiogenesis at the large vessels. The arteriovenous (AV) shunt was made on the thigh of male Wistar rats (n = 27) to increase blood flow, wrapped with artificial skin dermis, which consisted of a silicon outer layer, and isolated from sur...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02345133
更新日期：2005-01-01 00:00:00
abstract：:In a previous paper we demonstrated that the linear portion of the pressure-velocity loop (PU-loop) corresponding to early systole could be used to calculate the local wave speed. In this paper we extend this work to show that determination of the time at which the PU-loop first deviates from linearity provides a conv...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-007-0241-7
更新日期：2007-12-01 00:00:00
abstract：:Most tissues are subject to some form of physiological mechanical loading which results in deformation of the cells triggering intracellular mechanotransduction pathways. This response to loading is generally essential for the health of the tissue, although more pronounced deformation may result in cell and tissue dam...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章,评审
doi：10.1007/s11517-008-0381-4
更新日期：2008-10-01 00:00:00
abstract：:The fast hybrid operator splitting (HOS) and stable uniformization (UNI) methods have been proposed to save computation cost and enhance stability for Markov chain model in cardiac cell simulations. Moreover, Chen-Chen-Luo's quadratic adaptive algorithm (CCL) combined with HOS or UNI was used to improve the tradeoff b...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-020-02220-x
更新日期：2020-09-01 00:00:00
abstract：:Disappointing results for total ankle replacement have been explained by poor knowledge of the mechanics of the intact and replaced joints. Dynamic simulation tools have the capacity to simulate dynamic conditions that occur in human joints. The Working Model 2D tool was used to simulate the mechanics of the intact an...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02348124
更新日期：2002-03-01 00:00:00
abstract：:A new ambulatory technique for qualitative and quantitative movement analysis of the humerus is presented. 3D gyroscopes attached on the humerus were used to recognize the movement of the arm and to classify it as flexion, abduction and internal/external rotations. The method was first validated in a laboratory settin...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-009-0464-x
更新日期：2009-05-01 00:00:00
abstract：:The authors have applied estimation theory to the problem of determining primary current distributions from measured neuromagnetic fields. In this procedure, essentially nothing is assumed about the source currents, except that they are spatially restricted to a certain region. Simulation experiments show that the res...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02512476
更新日期：1994-01-01 00:00:00
abstract：:The paper describes an investigation in which it is shown that small positive voltage pulses applied to an external conductor placed against the photocathode of a photomultiplier tube can be used to switch the photocathode completely off for the duration of the pulses. This suggests that a photomultiplier tube with a ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02441486
更新日期：1989-05-01 00:00:00
abstract：:During scoliosis instrumentation surgery, it is difficult for surgeons fully to track vertebral motion in 3D, because only the posterior elements of the spine are exposed. Different intra-operative modelling approaches are evaluated using a registration technique that matches intra-operative measurements with a 3D pre...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02513328
更新日期：1999-07-01 00:00:00
abstract：:Proper alignment of acetabular implantation is necessary for good patient outcomes and preventing complications or additional surgeries in total hip arthroplasty (THA). Rotation of the pelvis in lateral decubitus (LD) is typically not accounted for as surgeons use the surgery table as a reference plane to align implan...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-020-02235-4
更新日期：2020-10-01 00:00:00
abstract：:The development of computer technology now allows the quick and efficient automatic fluorescence microscopy generation of a large number of images of proteins in specific subcellular compartments using fluorescence microscopy. Digital image processing and pattern recognition technology can easily classify these images...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-018-01946-z
更新日期：2019-06-01 00:00:00
abstract：:Leukaemia is a type of blood cancer which mainly occurs when bone marrow produces excess white blood cells in our body. This disease not only affects adult but also is a common cancer type among children. Treatment of leukaemia depends on its type and how far the disease has spread in the body. Leukaemia is classified...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-020-02282-x
更新日期：2020-12-01 00:00:00
abstract：:With the advent of biomedical imaging technology, the number of captured and stored biomedical images is rapidly increasing day by day in hospitals, imaging laboratories and biomedical institutions. Therefore, more robust biomedical image analysis technology is needed to meet the requirement of the diagnosis and class...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-018-1819-y
更新日期：2019-01-01 00:00:00
