A novel fused convolutional neural network for biomedical image classification.

Abstract:

:With the advent of biomedical imaging technology, the number of captured and stored biomedical images is rapidly increasing day by day in hospitals, imaging laboratories and biomedical institutions. Therefore, more robust biomedical image analysis technology is needed to meet the requirement of the diagnosis and classification of various kinds of diseases using biomedical images. However, the current biomedical image classification methods and general non-biomedical image classifiers cannot extract more compact biomedical image features or capture the tiny differences between similar images with different types of diseases from the same category. In this paper, we propose a novel fused convolutional neural network to develop a more accurate and highly efficient classifier for biomedical images, which combines shallow layer features and deep layer features from the proposed deep neural network architecture. In the analysis, it was observed that the shallow layers provided more detailed local features, which could distinguish different diseases in the same category, while the deep layers could convey more high-level semantic information used to classify the diseases among the various categories. A detailed comparison of our approach with traditional classification algorithms and popular deep classifiers across several public biomedical image datasets showed the superior performance of our proposed method for biomedical image classification. In addition, we also evaluated the performance of our method in modality classification of medical images using the ImageCLEFmed dataset. Graphical abstract The graphical abstract shows the fused, deep convolutional neural network architecture proposed for biomedical image classification. In the architecture, we can clearly see the feature-fusing process going from shallow layers and the deep layers.

journal_name

Med Biol Eng Comput

authors

Pang S,Du A,Orgun MA,Yu Z

doi

10.1007/s11517-018-1819-y

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

107-121

issue

1

eissn

0140-0118

issn

1741-0444

pii

10.1007/s11517-018-1819-y

journal_volume

57

pub_type

杂志文章
  • Classifying changes in LN-18 glial cell morphology: a supervised machine learning approach to analyzing cell microscopy data via FIJI and WEKA.

    abstract::In cell-based research, the process of visually monitoring cells generates large image datasets that need to be evaluated for quantifiable information in order to track the effectiveness of treatments in vitro. With the traditional, end-point assay-based approach being error-prone, and existing computational approache...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-020-02177-x

    authors: Mbiki S,McClendon J,Alexander-Bryant A,Gilmore J

    更新日期:2020-07-01 00:00:00

  • Finite element modeling of the growth plate in a detailed spine model.

    abstract::Very few computer models of the spine integrate vertebral growth plates to investigate their mechanical behavior and potential impacts on bone growth. An approach was developed to generate a finite element (FE) model of the lumbar spine and their connective tissues including the growth plate, which allowed a personali...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-007-0220-z

    authors: Sylvestre PL,Villemure I,Aubin CE

    更新日期:2007-10-01 00:00:00

  • Spectral moments of mechanomyographic signals recorded with accelerometer and microphone during sustained fatiguing contractions.

    abstract::The aim of this study was to analyse the trends of the first three power spectral moments of the mechanomyogram (MMG) signal recorded by a microphone (MMG(MIC)) and an accelerometer (MMG(ACC)) during sustained contractions. MMG signals were recorded from the biceps brachii muscle in 14 healthy male subjects during a 3...

    journal_title:Medical & biological engineering & computing

    pub_type: 临床试验,杂志文章

    doi:10.1007/s11517-006-0036-2

    authors: Madeleine P,Ge HY,Jaskólska A,Farina D,Jaskólski A,Arendt-Nielsen L

    更新日期:2006-04-01 00:00:00

  • Influence of synchronous and sequential stimulation on muscle fatigue.

    abstract::In acute experiments the sciatic nerve of the rat is electrically stimulated to induce fatigue in the medial Gastrocnemius muscle. Fatigue tests are carried out using intermittent stimulation of different compartments (sequential) or a single compartment (synchronous) of the sciatic nerve. The activation of different ...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02530036

    authors: Thomsen M,Veltink PH

    更新日期:1997-05-01 00:00:00

  • Extraction of Cole parameters from the electrical bioimpedance spectrum using stochastic optimization algorithms.

    abstract::Fitting the measured bioimpedance spectroscopy (BIS) data to the Cole model and then extracting the Cole parameters is a common practice in BIS applications. The extracted Cole parameters then can be analysed as descriptors of tissue electrical properties. To have a better evaluation of physiological or pathological p...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-015-1355-y

    authors: Gholami-Boroujeny S,Bolic M

    更新日期:2016-04-01 00:00:00

  • Exactness of source analysis of biomagnetic signals of epileptiform spikes by the method of spatial filtering: a computer simulation.

    abstract::On the basis of spatial covariance it is found that, by spatial filtering the localisation of a single dipole source, both parallel and perpendicular to the measurement plane (assuming a signal-noise ratio of 5:1), can be performed with an accuracy of < 0.5 mm. When the signal-noise ratio is increased to 30:1, the res...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02510982

    authors: Wagner H,Eiselt M,Zwiener U

    更新日期:1997-11-01 00:00:00

  • Continuous cardiac output monitoring system.

    abstract::A continuous cardiac output monitoring system has been developed in the laboratory to allow the real-time measurement of the cardiac output. This form of continuous cardiac output measurement allows the doctor to view the beat-to-beat cardiac output and can be employed to measure artery constrictions as well. The sens...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02345272

    authors: Tjin SC,Ho YC,Lam YZ,Hao J,Ng BK

    更新日期:2001-01-01 00:00:00

  • Recording of physiological signals with domestic videotape storage.

    abstract::A system is presented for the recording of physiological signals on an unmodified domestic videocassette recorder (VCR). A modification in the vertical synchronism pulses permits the recording of continuous analogue signals without significant loss of samples. The system allows up to 16 input channels, with a maximum ...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02447101

    authors: Salvador CH,Rosende P,González MA

    更新日期:1991-03-01 00:00:00

  • Fast body part segmentation and tracking of neonatal video data using deep learning.

    abstract::Photoplethysmography imaging (PPGI) for non-contact monitoring of preterm infants in the neonatal intensive care unit (NICU) is a promising technology, as it could reduce medical adhesive-related skin injuries and associated complications. For practical implementations of PPGI, a region of interest has to be detected ...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-020-02251-4

    authors: Antink CH,Ferreira JCM,Paul M,Lyra S,Heimann K,Karthik S,Joseph J,Jayaraman K,Orlikowsky T,Sivaprakasam M,Leonhardt S

    更新日期:2020-12-01 00:00:00

  • Application of artificial neural network model combined with four biomarkers in auxiliary diagnosis of lung cancer.

    abstract::The purpose of the study was to explore the application of artificial neural network model in the auxiliary diagnosis of lung cancer and compare the effects of back-propagation (BP) neural network with Fisher discrimination model for lung cancer screening by the combined detections of four biomarkers of p16, RASSF1A a...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-016-1585-7

    authors: Duan X,Yang Y,Tan S,Wang S,Feng X,Cui L,Feng F,Yu S,Wang W,Wu Y

    更新日期:2017-08-01 00:00:00

  • French legal framework relating to human tissues and cells.

    abstract::Thousands of patients receive human tissue grafts every year. Developments in cell and tissue engineering have also increased considerably the number of available products of human origin. France has very strict regulations, in part stimulated by problems of public health and ethics that have emerged in recent years a...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02344783

    authors: Pascal P,Damour O,Colpart JJ,Braye F

    更新日期:2000-03-01 00:00:00

  • Towards a patient-specific hepatic arterial modeling for microspheres distribution optimization in SIRT protocol.

    abstract::Selective internal radiation therapy (SIRT) using Yttrium-90 loaded glass microspheres injected in the hepatic artery is an emerging, minimally invasive therapy of liver cancer. A personalized intervention can lead to high concentration dose in the tumor, while sparing the surrounding parenchyma. We propose a computat...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-017-1703-1

    authors: Simoncini C,Jurczuk K,Reska D,Esneault S,Nunes JC,Bellanger JJ,Saint-Jalmes H,Rolland Y,Eliat PA,Bézy-Wendling J,Kretowski M

    更新日期:2018-03-01 00:00:00

  • Quantitative analysis of images in erythropoietin doping control.

    abstract::The software system GASepo has been developed as a tool to visualise and analyse doping (searching for performance-enhancing drugs in sports) with recombinant erythropoietin (rEpo). Digital images derived from the separation of Epo isoforms in gels by iso-electric focusing followed by double blotting and chemiluminesc...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02345819

    authors: Bajla I,Holländer I,Gmeiner G,Reichel Ch

    更新日期:2005-05-01 00:00:00

  • Comparison between human awake, meditation and drowsiness EEG activities based on directed transfer function and MVDR coherence methods.

    abstract::This study examined the electroencephalogram functional connectivity (coherence) and effective connectivity (flow of information) of selected brain regions during three different attentive states: awake, meditation and drowsiness. For the estimation of functional connectivity (coherence), Welch and minimum variance di...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-015-1272-0

    authors: Dissanayaka C,Ben-Simon E,Gruberger M,Maron-Katz A,Sharon H,Hendler T,Cvetkovic D

    更新日期:2015-07-01 00:00:00

  • Time-varying digital filtering of ECG baseline wander.

    abstract::Time-varying filtering techniques are applied to the problem of baseline correction by letting the cut-off frequency of a linear filter be controlled by the low-frequency properties of the ECG signal. The time-varying filter is implemented as a bank of linear low-pass filters, in which each filter has a slightly diffe...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02441986

    authors: Sörnmo L

    更新日期:1993-09-01 00:00:00

  • Evaluating the relationship of non-phase locked activities in the electroencephalogram during intermittent stimulation: a partial coherence-based approach.

    abstract::Partial coherence estimate between two signals removing the contribution of a periodic, deterministic one is proposed for measuring the coherence between two ongoing eletroencephalografic (EEG) activities collected at distinct cortical regions under sensory stimulation. The estimator expression was derived and shown t...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-007-0191-0

    authors: Miranda de Sá AM,Infantosi AF

    更新日期:2007-07-01 00:00:00

  • Registration and geometric modelling of the spine during scoliosis surgery: a comparison study of different pre-operative reconstruction techniques and intra-operative tracking systems.

    abstract::During scoliosis instrumentation surgery, it is difficult for surgeons fully to track vertebral motion in 3D, because only the posterior elements of the spine are exposed. Different intra-operative modelling approaches are evaluated using a registration technique that matches intra-operative measurements with a 3D pre...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02513328

    authors: Mac-Thiong JM,Aubin CE,Dansereau J,de Guise JA,Brodeur P,Labelle H

    更新日期:1999-07-01 00:00:00

  • Design of a novel mobility device controlled by the feet motion of a standing child: a feasibility study.

    abstract::Self-generated mobility is a major contributor to the physical, emotional, cognitive, and social development of infants and toddlers. When young children have disorders that hinder self locomotion, their development is at risk for delay. Independent mobility via traditional power mobility devices may prevent this dela...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-011-0820-5

    authors: Schoepflin ZR,Chen X,Ragonesi CB,Galloway JC,Agrawal SK

    更新日期:2011-10-01 00:00:00

  • Three-dimensional changes of the cytoskeleton of vascular endothelial cells exposed to sustained hydrostatic pressure.

    abstract::The three-dimensional changes in the cytoskeleton and in cell proliferation of bovine pulmonary artery endothelial cells when exposed to sustained hydrostatic pressure were investigated in vitro using laser scanning confocal microscopy. Subconfluent endothelial cells on rigid substrates were exposed to 1.5, 5 and 10 c...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02523225

    authors: Salwen SA,Szarowski DH,Turner JN,Bizios R

    更新日期:1998-07-01 00:00:00

  • Analysis of amplitude and frequency variations of essential and Parkinsonian tremors.

    abstract::Variations in the amplitude and period of essential and Parkinsonian tremors were studied. It was found that the variations in frequency (or period) were mostly similar to the white noise, with the standard deviation typically less than 10% of the mean, whereas the variations in amplitude were much larger, with standa...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02344710

    authors: Gao JB

    更新日期:2004-05-01 00:00:00

  • Multiregional viscoelastic characterization of the corona radiata in the sagittal plane of the porcine brain.

    abstract::Detailed finite element (FE) models are used as promising tools to investigate traumatic brain injuries, although their accuracy is strongly dependent on the characterization of the mechanical behaviors of the different anatomic structures in the brain. In some cases, when the FE models require finer spatial resolutio...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-018-1891-3

    authors: Pan C,Chen F,Zhou J,Li X,Zhao F,Zhang X

    更新日期:2019-03-01 00:00:00

  • Industrial wideband noise reduction for hearing aids using a headset with adaptive-feedback active noise cancellation.

    abstract::High-intensity noises are a health hazard for industrial workers, and hearing protection is necessary to prevent hearing loss. Passive methods, such as ear muffs, are ineffective against low-frequency noise. Moreover, many hearing-impaired workers must wear hearing aids to enable communication at their workplace, and ...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02430951

    authors: Lin JH,Li PC,Tang ST,Liu PT,Young ST

    更新日期:2005-11-01 00:00:00

  • Efficient and robust estimation of blood oxygenation levels in single cerebral veins.

    abstract::Blood oxygenation level is an important measure that can be used alongside functional magnetic resonance imaging data in order to obtain closer correlates of neuronal activation. A robust estimate of this measure has thus far not been demonstrated. This is mainly due to the lack of knowledge of the underlying paramete...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-012-0886-8

    authors: Dagher J,Du YP

    更新日期:2012-05-01 00:00:00

  • Estimation of single motor unit conduction velocity from surface electromyogram signals detected with linear electrode arrays.

    abstract::This work addresses the problem of estimating the conduction velocity (CV) of single motor unit (MU) action potentials from surface EMG signals detected with linear electrode arrays during voluntary muscle contractions. In ideal conditions, that is without shape or scale changes of the propagating signals and with add...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02344807

    authors: Farina D,Muhammad W,Fortunato E,Meste O,Merletti R,Rix H

    更新日期:2001-03-01 00:00:00

  • Effect of mains interference on time coherent averaging.

    abstract::The paper deals with the influence of mains interference on time coherent averaging using an internal trigger. The general distribution of the time jitter is derived and applied to a simplified signal. The authors prove that no amount of averaging can do away with this type of interference. Finally, the deformation th...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02457827

    authors: Strackee J,Peper A

    更新日期:1992-09-01 00:00:00

  • Using a numerical method to precisely evaluate the alpha angle in a hip image.

    abstract::The alpha angle is a parameter extensively used to assess for cam-type femoroacetabular impingement (FAI) in a 2D image of the hip. As this angle requires estimation of the axis of the femoral neck, the drawing of this axis often results in measurement errors due to subjective judgment, influencing inter-rater and int...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-019-01973-4

    authors: Lai CL,Chi WM,Ho YJ,Lin CC,Lin HC,Kuo CL,Chen JH

    更新日期:2019-07-01 00:00:00

  • Robust segmentation and intelligent decision system for cerebrovascular disease.

    abstract::Segmentation and classification of low-quality and noisy ultrasound images is challenging task. In this paper, a new approach is proposed for robust segmentation and classification of carotid artery ultrasound images and consequently, detecting cerebrovascular disease. The proposed technique consists of two phases, in...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-016-1481-1

    authors: Chaudhry A,Hassan M,Khan A

    更新日期:2016-12-01 00:00:00

  • Filtered maximum likelihood expectation maximization based global reconstruction for bioluminescence tomography.

    abstract::The reconstruction of bioluminescence tomography (BLT) is severely ill-posed due to the insufficient measurements and diffuses nature of the light propagation. Predefined permissible source region (PSR) combined with regularization terms is one common strategy to reduce such ill-posedness. However, the region of PSR i...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/s11517-018-1842-z

    authors: Yang D,Wang L,Chen D,Yan C,He X,Liang J,Chen X

    更新日期:2018-11-01 00:00:00

  • Interpreting magnetic fields of the brain: minimum norm estimates.

    abstract::The authors have applied estimation theory to the problem of determining primary current distributions from measured neuromagnetic fields. In this procedure, essentially nothing is assumed about the source currents, except that they are spatially restricted to a certain region. Simulation experiments show that the res...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02512476

    authors: Hämäläinen MS,Ilmoniemi RJ

    更新日期:1994-01-01 00:00:00

  • Pressures generated by rib cage and abdominal compressions during cardiopulmonary resuscitation.

    abstract::When the rib cage and abdomen are compressed during cardiopulmonary resuscitation (CPR), the effect on intrathoracic pressure, and therefore on haemodynamics, cannot be quantitatively predicted without a physiologically based mathematical model of chest wall dynamics. Using such a model, we compared model simulations ...

    journal_title:Medical & biological engineering & computing

    pub_type: 杂志文章

    doi:10.1007/BF02441676

    authors: Ben-Haim SA,Shofti R,Dinnar U,Saidel GM

    更新日期:1990-01-01 00:00:00