Abstract:
:Self-generated mobility is a major contributor to the physical, emotional, cognitive, and social development of infants and toddlers. When young children have disorders that hinder self locomotion, their development is at risk for delay. Independent mobility via traditional power mobility devices may prevent this delay, but do little to encourage the child's development of gross motor skills. This research aims to develop a bio-driven mobile-assistive device that is controlled and driven by moving the feet, which may encourage the development of gross motor skills. In this study, system feasibility is shown by experiments on five typically developing toddlers and one special needs toddler with spastic cerebral palsy. Children were placed in the bio-driven device and instructed to navigate through a maze. All subjects were able to successfully complete the maze in multiple trials. In addition, two toddlers showed evidence of improved driving skill by completing the maze in shorter times in successive trials on a given testing day. The results suggest that such a device is feasible for purposeful driving. Recommendations are given for the device and protocol redesign for related future testing.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Schoepflin ZR,Chen X,Ragonesi CB,Galloway JC,Agrawal SKdoi
10.1007/s11517-011-0820-5subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1225-31issue
10eissn
0140-0118issn
1741-0444journal_volume
49pub_type
杂志文章abstract::Disappointing results for total ankle replacement have been explained by poor knowledge of the mechanics of the intact and replaced joints. Dynamic simulation tools have the capacity to simulate dynamic conditions that occur in human joints. The Working Model 2D tool was used to simulate the mechanics of the intact an...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02348124
更新日期:2002-03-01 00:00:00
abstract::The aim of this work is to quantify individual and regional differences in the relative concentration of gamma-aminobutyric acid (GABA) in human brain with in vivo magnetic resonance spectroscopy. Spectral editing Mescher-Garwood point resolved spectroscopy (MEGA-PRESS) sequence and GABA analysis toolkit (Gannet) were...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-016-1579-5
更新日期:2017-06-01 00:00:00
abstract::We introduce a novel method for an automatic classification of subjects to those with or without neuromuscular disorders. This method is based on multiscale entropy of recorded surface electromyograms (sEMGs) and support vector classification. The method was evaluated on a single-channel experimental sEMGs recorded fr...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-010-0629-7
更新日期:2010-08-01 00:00:00
abstract::Due to its capabilities in analysing injury risk, the ability to analyse an athlete's ground reaction force and joint moments is of high interest in sports biomechanics. However, using force plates for the kinetic measurements influences the athlete's performance. Therefore, this study aims to use a feed-forward neura...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-019-02000-2
更新日期:2019-08-01 00:00:00
abstract::The long QT syndrome (LQTS) is a genetic disorder, typically characterized by a prolonged QT interval in the ECG due to abnormal cardiac repolarization. LQTS may lead to syncopal episodes and sudden cardiac death. Various parameters based on T-wave morphology, as well as the QT interval itself have been shown to be us...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-006-0061-1
更新日期:2006-07-01 00:00:00
abstract::Results of self-consistent analyses of cells show the possibility of temperature increases at membranes in response to a single nanosecond, high-voltage pulse, at least over small sections of the membrane. Molecular Dynamics simulations indicate that such a temperature increase could facilitate poration, which is one ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-011-0745-z
更新日期:2011-06-01 00:00:00
abstract::The boundary-element method (BEM) is widely used for electrocardiogram (ECG) simulation. Its major disadvantage is its perceived inability to deal with the anisotropic electric conductivity of the myocardial interstitium, which led researchers to represent only intracellular anisotropy or neglect anisotropy altogether...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-009-0472-x
更新日期:2009-07-01 00:00:00
abstract::Protein glycosylation is one of the most important and complex post-translational modification that provides greater proteomic diversity than any other post-translational modification. Fast and reliable computational methods to identify glycosylation sites are in great demand. Two key issues, feature encoding and feat...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-015-1268-9
更新日期:2015-06-01 00:00:00
abstract::The mechanism of brain contusion has been investigated using a series of three-dimensional (3D) finite element analyses. A head injury model was used to simulate forward and backward rotation around the upper cervical vertebra. Intracranial pressure and shear stress responses were calculated and compared. The results ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02347044
更新日期:2000-05-01 00:00:00
abstract::Vascular access for renal dialysis is a lifeline for about 120 000 individuals in the United States. Stethoscope auscultation of vascular sounds has some utility in the assessment of access patency, yet can be highly skill-dependent. The objective of the study was to identify acoustic parameters that are related to ch...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02345123
更新日期:2005-01-01 00:00:00
abstract::Conduct disorder (CD) is an important mental health problem in childhood and adolescence. There is presently a trend of revealing neural mechanisms using measures of brain networks. This study goes further by presenting a classification scheme to distinguish subjects with CD from typically developing healthy subjects ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-020-02215-8
更新日期:2020-09-01 00:00:00
abstract::Steady-state visual evoked potentials (SSVEPs) are widely employed in brain-computer interface (BCI) applications, especially to control machines. However, the use of SSVEPs leads to eye fatigue and causes lower accuracy over the long term, particularly when multi-commands are required. Therefore, this paper proposes ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-016-1560-3
更新日期:2017-06-01 00:00:00
abstract::Electrocardiogram (ECG)-triggered laser Doppler perfusion monitoring (LDPM) was used to assess myocardial perfusion, with minimum myocardial tissue motion influence, during coronary artery bypass grafting (CABG). Thirteen subjects were investigated at six phases: pre- and post-CABG; post aorta cross-clamping; pre and ...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02351031
更新日期:2005-09-01 00:00:00
abstract::Sealing resistance is highly significant with respect to the electrical neuron-electrode contact because it decreases the stimulation threshold of neurons cultured on a planar micro-electrode array. A method is proposed for measurement of the sealing resistance using impedance spectroscopy. The effect of the sealing r...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02524436
更新日期:1998-09-01 00:00:00
abstract::Generation of a large number of cells belonging to the cardiac pacemaker system would constitute an important step towards their utilization as a biological cardiac pacemaker system. The aim of the present study was to identify factors, which might induce transformation of a heterogenous population of fetal cardiomyoc...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-007-0164-3
更新日期:2007-02-01 00:00:00
abstract::This study describes a new method for analyzing microcirculatory videos. It introduces algorithms for quantitative assessment of vessel length, diameter, the functional microcirculatory density distribution and red blood-cell (RBC) velocity in individual vessels as well as its distribution. The technique was validated...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-008-0349-4
更新日期:2008-07-01 00:00:00
abstract::Currently, simulations of the induced currents in the brain produced by transcranial magnetic stimulation (TMS) are used to elucidate the regions reached by stimuli. However, models commonly found in the literature are too general and neglect imperfections in the windings. Aiming to predict the stimulation sites in pa...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-020-02156-2
更新日期:2020-07-01 00:00:00
abstract::Magnetoenterography (MENG) is a new, non-invasive technique that measures gastrointestinal magnetic signals near the body surface. This study was undertaken to evaluate the temporal and spatial characteristics of the magnetic signals generated by gastric and duodenal slow wave activity. The gastrointestinal magnetic f...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02513347
更新日期:1999-09-01 00:00:00
abstract::A three-layer Newtonian model is investigated using a combined Eulerian-Lagrangian computational method to describe the dynamic behaviour of leukocytes. The model, composed of a cell membrane (outer layer), cytoplasm (middle layer) and nucleus (inner layer), can better describe the recovery characteristics because lar...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02510753
更新日期:1998-03-01 00:00:00
abstract::Very few computer models of the spine integrate vertebral growth plates to investigate their mechanical behavior and potential impacts on bone growth. An approach was developed to generate a finite element (FE) model of the lumbar spine and their connective tissues including the growth plate, which allowed a personali...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-007-0220-z
更新日期:2007-10-01 00:00:00
abstract::The aim of this study was to develop a radiation-free method to measure gastric emptying. Such a method would be useful e.g. for patients who need repeated measurements and in pregnancy. Ferrimagnetic particles (gamma-Fe2O3), ingested within a solid test meal (pancakes), were magnetised by an applied magnetic field. A...
journal_title:Medical & biological engineering & computing
pub_type: 临床试验,杂志文章
doi:10.1007/BF02522849
更新日期:1998-01-01 00:00:00
abstract::A strict EIT reconstruction algorithm, the general inversion algorithm (GIA) is presented. To improve the noise performance, the algorithm is modified by attenuating the condition number of the forward matrix F and implemented using an improved FEM scheme, to obtain the 2D image of impedance change (dynamic image). Th...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02523205
更新日期:1998-07-01 00:00:00
abstract::The energy storage capacity of the human foot as a passive structure depends on both its geometry and elastic properties. The present study examines theoretically the relationship between the energy stored in the longitudinal arch and the inclination of the calcaneus, when a vertical load is applied. A simple two-dime...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02441770
更新日期:1990-03-01 00:00:00
abstract::Monitoring upper-limb activity in a free-living environment is important for the evaluation of rehabilitation. This study is a validation of the Strathclyde Upper-Limb Activity Monitor (SULAM) which records the vertical movement and position of each wrist, and assesses bimanual movement. Agreement between the SULAM an...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-007-0233-7
更新日期:2007-10-01 00:00:00
abstract::Classification of cancerous genes from microarray data is an important research area in bioinformatics. Large amount of microarray data are available, but it is very costly to label them. This paper proposes an active learning model, a semi-supervised classification approach, to label the microarray data using which p...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-020-02238-1
更新日期:2020-10-01 00:00:00
abstract::Gait disturbances are common in the rat model of Parkinson's disease (PD) by administrating 6-hydroxydopamine. However, few studies have simultaneously assessed spatiotemporal gait indices and the kinematic information of PD rats during overground locomotion. This study utilized a simple, accurate, and reproducible me...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-012-0933-5
更新日期:2012-09-01 00:00:00
abstract::In a previous paper we demonstrated that the linear portion of the pressure-velocity loop (PU-loop) corresponding to early systole could be used to calculate the local wave speed. In this paper we extend this work to show that determination of the time at which the PU-loop first deviates from linearity provides a conv...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-007-0241-7
更新日期:2007-12-01 00:00:00
abstract::Bone mass and microarchitecture are the main determinants of bone strength. Three-dimensional micro-computed tomography has the potential to examine complete bones of small laboratory animals with very high resolution in a non-invasive way. In the presented work, the proximal part of the tibiae of hindlimb unloaded an...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/BF02347054
更新日期:2000-05-01 00:00:00
abstract::Measurements of the dielectric properties of healthy and atherosclerotic human artery tissues were made in the frequency range of 100 Hz-100 kHz and temperatures from 22 to 260 degrees C. The temperature dependencies of the dielectric parameters for healthy tissues reveal distinctively the temperature ranges correspon...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-007-0181-2
更新日期:2007-06-01 00:00:00
abstract::In total hip arthroplasty, determining the impingement free range of motion requirement is a complex task. This is because in the native hip, motion is restricted by both impingement as well as soft tissue restraint. The aim of this study is to determine a range of motion benchmark which can identify motions which are...
journal_title:Medical & biological engineering & computing
pub_type: 杂志文章
doi:10.1007/s11517-012-1016-3
更新日期:2013-04-01 00:00:00