Abstract：
:Most tissues are subject to some form of physiological mechanical loading which results in deformation of the cells triggering intracellular mechanotransduction pathways. This response to loading is generally essential for the health of the tissue, although more pronounced deformation may result in cell and tissue damage. In order to determine the biological response of cells to loading it is necessary to understand how cells and intracellular structures deform. This paper reviews the various loading systems that have been adopted for studying cell deformation both in situ within tissue explants and in isolated cell culture systems. In particular it describes loading systems which facilitate visualisation and subsequent quantification of cell deformation. The review also describes the associated microscopy and image analysis techniques. The review focuses on deformation of chondrocytes with additional information on a variety of other cell types including neurons, red blood cells, epithelial cells and skin and muscle cells.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Bader DL,Knight MMdoi
10.1007/s11517-008-0381-4subject
Has Abstractpub_date
2008-10-01 00:00:00pages
951-63issue
10eissn
0140-0118issn
1741-0444journal_volume
46pub_type
杂志文章,评审abstract：:Smoothing and differentiation of noisy signals are common problems whenever it is difficult or impossible to obtain derivatives by direct measurement. In biomechanics body displacements are frequently assessed and these measurements are affected by noise. To avoid high-frequency noise magnification, data filtering bef...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
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journal_title：Medical & biological engineering & computing
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journal_title：Medical & biological engineering & computing
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journal_title：Medical & biological engineering & computing
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journal_title：Medical & biological engineering & computing
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journal_title：Medical & biological engineering & computing
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journal_title：Medical & biological engineering & computing
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journal_title：Medical & biological engineering & computing
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journal_title：Medical & biological engineering & computing
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journal_title：Medical & biological engineering & computing
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journal_title：Medical & biological engineering & computing
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journal_title：Medical & biological engineering & computing
pub_type： 杂志文章,评审
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journal_title：Medical & biological engineering & computing
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journal_title：Medical & biological engineering & computing
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